3.4.21.46: complement factor D
This is an abbreviated version!
For detailed information about complement factor D, go to the full flat file.
Word Map on EC 3.4.21.46
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3.4.21.46
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angiogenesis
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angiogenic
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vessel
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metastasis
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neovascularization
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hypoxia
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artery
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hypoxia-inducible
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necrosis
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retinal
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antiangiogenic
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umbilical
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bevacizumab
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microvessels
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vein
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capillary
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factor-1
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huvecs
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vegfr-2
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collagen
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vasculature
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retinopathy
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eyes
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ovarian
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macular
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tumour
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tube
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microvascular
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mesenchymal
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anti-vegf
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lymphatic
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receptor-2
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pro-angiogenic
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bfgf
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intravitreal
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progression-free
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edema
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choroid
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metalloproteinase
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endothelium
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hypertension
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sprout
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matrigel
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paracrine
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lymph
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hif-1alpha
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mmp-9
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sunitinib
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drug development
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sorafenib
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vitreous
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medicine
- 3.4.21.46
- angiogenesis
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angiogenic
- vessel
- metastasis
- neovascularization
- hypoxia
- artery
-
hypoxia-inducible
- necrosis
- retinal
-
antiangiogenic
-
umbilical
-
bevacizumab
-
microvessels
- vein
- capillary
- factor-1
- huvecs
- vegfr-2
- collagen
- vasculature
- retinopathy
- eyes
- ovarian
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macular
- tumour
- tube
-
microvascular
- mesenchymal
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anti-vegf
- lymphatic
- receptor-2
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pro-angiogenic
- bfgf
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intravitreal
-
progression-free
- edema
- choroid
- metalloproteinase
- endothelium
- hypertension
-
sprout
- matrigel
-
paracrine
- lymph
- hif-1alpha
- mmp-9
- sunitinib
- drug development
- sorafenib
- vitreous
- medicine
Reaction
selective cleavage of Arg-/-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor =
Synonyms
28 kDa protein, adipocyte, Adipsin, alternative complement pathway component Factor D, C3 convertase activator, C3 proactivator convertase, CFD, complement factor D/adipsin and kallikrein-like serine protease, convertase, C3 proactivator, Df, Df protein, endogenous vascular elastase, esterase, properdin factor D, factor D, factor D (complement), fD, PDGF-D, platelet-derived growth factor D, PoDAK, vascular endothelial growth factor, vascular endothelial growth factor D, VEGF-D
ECTree
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Source Tissue
Source Tissue on EC 3.4.21.46 - complement factor D
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PDGF-D is widely expressed in most neointimas in arteries exhibiting the chronic arteriopathy of chronic allograft nephropathy and is only weakly expressed in a small proportion of sclerotic arteries. The neointimal cells expressing PDGF-D are alpha-smooth muscle actin-expressing cells, but not infiltrating macrophages or endothelial cells
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PDGF-D high-expressing breast cancer cell line SUM-149 is more invasive compared to low-expressing cell lines
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PDGF-D expressing breast cancer cell lines are more invasive compared to non-expressing cell lines
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low PDGF-D expressing breast cancer cell line is less invasive
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5- to 8fold higher amounts of vegf-D mRNA as the other gastric cell lines
moderate mRNA expression determined by real-time RT-PCR
additional information
parasitized red blood cells, pRBC, infected by Plasmodium falciparum, rosetting serum dependent for the strains FCR3S1.2 and Malayan Camp
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transcript levels steadily increased from day 28 post-fertilization to hatch
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normal hepatocytes synthesize factor D constitutively. The liver may be a major source of plasma factor D
moderate mRNA expression determined by real-time RT-PCR
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PDGF-D is uniformly expressed in visceral epithelial cells and arteriolar wall in normal kidneys, kidneys with acute vascular rejection, and kidneys with chronic allograft nephropathy. In kidneys with acute vascular rejection, PDGF-D is expressed in arterial medial smooth muscle cells, some adventitial cells, and some neointimal cells that also have alpha-smooth muscle actin expression
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of patients on chronic ambulatory peritoneal dialysis
epithelial ovarian carcinoma and tumoral lymphatic vessels, high expression of VEGF-D is closely associated with the FIGO stage, intratumoral lymphatic vessels, tumoral lymphatic invasion, and lymph node metastasis as well as a shorter overall survival
additional information
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epithelial ovarian carcinoma and tumoral lymphatic vessels, high expression of VEGF-D is closely associated with the FIGO stage, intratumoral lymphatic vessels, tumoral lymphatic invasion, and lymph node metastasis as well as a shorter overall survival
additional information
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present in distal tubule and duct. Absent from proximal tubule and interstitium