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3.4.21.4: trypsin

This is an abbreviated version!
For detailed information about trypsin, go to the full flat file.

Word Map on EC 3.4.21.4

Reaction

preferential cleavage: Arg-/-, Lys-/- =

Synonyms

acrosin, alpha-trypsin, anionic salmon trypsin, anionic trypsin, Anionic trypsinogen, AST, aT-I, aT-II, Atlantic cod trypsin I, beta-trypsin, BPT, Brain trypsinogen, BT, cationic trypsin, Cationic trypsinogen, cocoonase, CST, EC 3.4.4.4, EFE, EG-T, fibrinolytic enzyme, gamma-trypsin, GM-T, group III trypsin, mesotrypsin, Mesotrypsinogen, midgut-specific serine protease 1, midgut-specific serine protease 2, More, p23, parenzyme, parenzymol, PPT, pro23, pseudotrypsin, SET, SGT, sperm receptor hydrolase, ST-1, ST-2, ST-3, TI, TIIA, TIII, TLE, TLE I, TLE II, TR-P, TR-S, tripcellim, TRP, Try, TRY-3, TryI, TryII, TryIII, TRYP, trypsin 1, trypsin 3A1, trypsin 4, trypsin A, trypsin B, trypsin I, trypsin IV, trypsin type III, trypsin Y, trypsin-1, trypsin-2, trypsin-3, trypsin-4, trypsin-like enzyme, trypsin-like serine proteinase, tryptar, tryptase, trypure, TrypZean, type I trypsin, type IX pancreatic trypsin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.4 trypsin

pH Stability

pH Stability on EC 3.4.21.4 - trypsin

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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1
-
0°C, 12 h, 20% loss of activity
95441
2
-
30 min, 5°C, about 55% loss of maximal activity
95432
2 - 10
-
0°C, very stable
95441
2.3
-
maximal sability
95427
3 - 13
-
purified enzyme, completely stable at pH 7.0-12.0, profile, overview
708553
4 - 10
-
at 20°C
668321
5 - 10
5 - 12
-
purified enzyme, 1 h, extremely stable at pH 7.0-9.0, profile, overview
708852
5 - 7
-
5°C, highest stability
95432
5.1 - 8.9
-
isoform T1
667239
5.2
-
pH 5.2 prevents autocatalytic hydrolysis of trypsin
699161
6 - 10
-
1 h, purified enzyme, the enzyme maintains over 100% of its original activity between pH 7.0 and pH 10.0, and more than 60% of its activity at pH 11.0 and pH 12.0, unstable below pH 6.0, inactive at pH 4.0
708550
6 - 11
6 - 12
6 - 8
purified enzyme, stable
717614
6.2 - 8.9
-
isoform T2
667239
7 - 10
-
purified enzyme, completely stable
708557
7 - 11
-
purified native trypsin A and trypsin B, stable
717516
7 - 12
-
very unstable below pH 7
680305
7 - 8
-
-
668318
7.2 - 9.9
-
isoform T3
667239
8 - 10
-
enzyme maintains more than 50% of its activity for a period of 2 h of incubation in the pH range 8-10
732249
additional information
-
significant stabilization in the neutral and alkaline range by 15 mM Ca2+
95441