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(2R,4R)-4-phenyl-1-[Nalpha-(7-methoxy-2-naphthalenesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid
competitive, small molecular weight inhibitor without tryptase inhibitor activity
(4-(6-chloro-naphthalene-2-sulfonyl)-piperazin-1-yl)-(3,4,5-6-tetrahydro[2H-1,4']bipyridinyl-4yl)-methanone
-
-
1-(L-trans-epoxysuccinyl-leucylamino)-4-guanidinobutane
1-[N2-[(7-methoxynaphthalen-2-yl)sulfonyl]-L-arginyl]-4-phenylpiperidine-2-carboxylic acid
IC50: 0.0003 mM
2,7-bis(4-amidinobenzylidene)-cycloheptan-1-one
-
-
2,7-bis(4-amidinobenzylidene)cycloheptan-1-one
-
unspecific strong inhibition
2-mercaptoethanol
-
0.1 mM, isoenzyme aT-I loses 90% of its activity, isoenzyme aT-II loses 93% of its activity
3,4-dichloroisocoumarin
-
-
4-(2-aminoethyl)-benzensulfonylfluoride
-
isozyme TryIII activity is completely (more than 95%) inhibited by 4-(2-aminoethyl)-benzensulfonylfluoride
4-(amidinophenyl)methanesulfonyl fluoride
-
-
6-amidino-2-naphthol
-
mixed-type inhibition
acetonitrile
-
partial inhibition at 20% acetonitrile, a 5% aqueous acetonitrile solution less likely reduces the activity of the porous polymer monolith-immobilized trypsin
acyclic SFTI
-
i.e. oSFTI, modified sunflower trypsin inhibitor 1, SFTI-1, generated by Fmoc-based automated synthesis
acyclic sun flower trypsin inhibitor-1
-
-
-
Adenanthera pavonina trypsin inhibitor
-
Adunil CEL
-
0.1% v/v, 47.3% residual activity
-
alpha-1-antitrypsin
-
in gestational diabetes mellitus reduction of serum trypsin inhibitory capacity may be due to non-enzymatic glycosylation of alpha-1-antitrypsin or oxidation of methionine in the active site of alpha-1-antitrypsin
-
alpha1-antitrypsin Pittsburgh
-
effective inhibitor, variant of alpha1-antitrypsin containing an Arg residue in place of the P1 Met358 in the reactive-site peptide bond
-
Apios Americana trypsin inhibitor
-
AATI, strong inhibitor, complete inhibition with Apios Americana trypsin inhibitor bound to trypsin in a 1:2 molar ratio
-
atropine
-
strongly diminishes trypsin activity in stressed animals
AVNIPFKVHFRCKAAFC
-
a small trypsin inhibitor from the skin secretion of the frog Odorrana grahami, only inhibits the hydrolysis activity of trypsin on synthetic chromogenic substrate
Bauhinia variegata var. variegata trypsin inhibitor
-
i.e. BvvTI, a Kunitz-type inhibitor from seeds of the Camels foot tree, Bauhinia variegata var. variegata. The inhibitor is also capable of significant inhibition of the proliferation of nasopharyngeal cancer CNE-1 cells in a selective way and of inhibiting anti-HIV-1 reverse transcriptase activity, overview
-
benzyloxycarbonyl-amino(4-guanidinophenyl)methyl-bis(4-ethylphenyl)phosphonate
-
50% inhibition at 0.000017 mM, comparison with inhibitory effect on urokinase
benzyloxycarbonyl-amino(4-guanidinophenyl)methyl-bis(4-isopropylphenyl)phosphonate
-
50% inhibition at 0.000061 mM, comparison with inhibitory effect on urokinase
benzyloxycarbonyl-amino(4-guanidinophenyl)methyl-bis(4-methylthiophenyl)phosphonate
-
50% inhibition at 0.0000087 mM, comparison with inhibitory effect on urokinase
benzyloxycarbonyl-amino(4-guanidinophenyl)methyl-bis(4-t-butylphenyl)phosphonate
-
50% inhibition at 0.000088 mM, comparison with inhibitory effect on urokinase
bis(m-amidinosalicylidene-L-alaninato)iron(III)
-
-
bis(p-amidinosalicylidene-L-alaninato)iron(III)
-
-
-
bisphenol A
-
the secondary and tertiary structures of trypsin are altered by bisphenol S binding, which results in the loosening of the skeleton of the enzyme. Bisphenol S induces microenvironmental changes around tyrosine and tryptophan residues of trypsin. The activity of trypsin does not change remarkably with the increasing concentration of bisphenol S. The binding of bisphenol S to trypsin is a spontaneous process and hydrogen bonding and hydrophobic interactions play a vital role in stabilizing the bisphenol S-trypsin complex. The binding constants of bisphenol S with trypsin are 74200 (25°C) and 59100 L/mol (37°C)
black gram trypsin inhibitor 1
-
highly effective trypsin inhibitor, 87.5% of trypsin inhibitory activity of black gram trypsin inhibitor 1 is retained after treatment with 10 mM dithiothreitol for 2 hours, and the activity dwindles to 12.5% after treatment with 100 mM dithiothreitol for 2 hours
-
black gram trypsin inhibitor 2
-
highly effective trypsin inhibitor, the trypsin inhibitory activity of black gram trypsin inhibitor 2 is unaffected after exposure to 100 mM dithiothreitol for 2 hours
-
black gram trypsin inhibitor 3
-
highly effective trypsin inhibitor, in the presence of 10 mM dithiothreitol trypsin inhibitory of black gram trypsin inhibitor 3 drops to 57.1% after 1 h and becomes undetectable after 2 hours, while treatment of 100 mM dithiothreitol for 1 h has the same effect
-
Bovine pancreatic trypsin inhibitor
-
bovine secretory inhibitors
-
A and B
-
BPTI-20st
-
simplified variant of bovine pancreatic trypsin inhibitor containing 20 alanines, retains a wild type level of trypsin inhibitory activity
-
BPTI-[5,55]st
-
single-disulfide-bonded variant of bovine pancreatic trypsin inhibitor, retains a wild type level of trypsin inhibitory activity
-
captopril
-
feeding angiotensin converting enzyme inhibitor captopril down-regulates trypsin activity in the larval gut, injecting third instar larvae with a combination of Aedes aegypti trypsin-modulating oostatic factor and captopril downregulates trypsin biosynthesis in the larval gut
Cd2+
-
10 mM, 48% inhibition
clispin
-
a Clitocybe nebularis trypsin inhibitor variant, recombinantly expressed in Escherichia coli, highly specific towards trypsin, fast-acting, and tight-binding. Molecular cloning of the gene and cDNA encoding cnispin, overview
Clitocybe nebularis trypsin inhibitor
-
CnSPI, several inhibitor variants, separation by trypsin affinity chromatography. Possible regulatory role for CnSPIs in the endogenous proteolytic system of Clitocybe nebularis. Isolation from frozen fruiting bodies or basidiocarps
-
cyclic SFTI
-
i.e. cSFTI, modified sunflower trypsin inhibitor 1, SFTI-1, generated by Fmoc-based automated synthesis
dithiothreitol
-
1 mM, no residual activity
DMTI-II
-
trypsin inhibitor from seeds of Dimorphandra mollis. The inhibitory activity is stable over a wide range and in the presence of DTT
-
domesticated soybean inhibitor
-
SBTI
-
DOTA-SFTI
-
modified sunflower trypsin inhibitor 1, SFTI-1, labeled, generated by Fmoc-based automated synthesis
Ecballium elaterium trypsin inhibitor II
-
EETI, a a model member of the knottin family, used for construction of libraries of EETI loop-substituted variants with diversity in both amino acid sequence and loop length, wild-type EETI or loop-substituted clones expressed from yeast, structure-function analysis, modelling, overview
-
enalapril
-
feeding angiotensin converting enzyme inhibitor enalapril down-regulates trypsin activity in the larval gut
ethylenediaminetetraacetic acid
-
partial
Gly-L-Arg-(2-amino butanoyl)-L-Thr-Nphe-L-Ser-L-Ile-L-Pro-L-Pro-L-Ile-(2-amino butanoyl)-L-Phe-L-Pro-L-Asp
-
-
Gly-L-Arg-L-Cys-L-Thr-L-Lys-L-Ser-L-Ile-L-Pro-L-Pro-L-Ile-L-Cys-L-Phe-L-Pro-L-Asp
-
sun flower trypsin inhibitor SFTI-1
Glycine max trypsin inhibitor
-
from raw soymilk, inhibition kinetics, overview
-
I-ovalbumin
-
high affinity interaction of enzyme with I-ovalbumin, the product of a heating transition of ovalbumin which acts as a potent reversible serine proteinase inhibitor. Interaction is characterized by high kinetic association constants and low kinetic dissociation konstants
-
iodoacetic acid
16.5% inhibition at 1 mM; 1 mM, 16.5% inhibition
K+
-
10 mM, 16% inhibition
Kunitz domain 1 of tissue factor pathway inhibitor-2
-
-
-
Kunitz type trypsin inhibitor from Glycine max
-
isolated and purified from Korean large black soybeans cultivar, overview. Inhibits bovine trypsin, but also shows Anti-HIV reverse transcriptase activity, cytokine-inducing activity and antiproliferative activity on tumor cell lines
-
L-1-chloro-3-tosylamido-4-phenyl-2-butanone
-
-
L-1-chloro-3-[4-tosylamido]-4-phenyl-2-butanone
-
-
L-Lys-L-Cys-L-Thr-Nlys-L-Ser-L-Ile-L-Pro-L-Pro-L-Ile-L-Cys-L-Phe-L-Pro-L-Asp
-
-
leech-derived tryptase inhibitor
-
i.e. LDTI, purely competitive inhibitor
-
LEKTI
-
the LEKI gene encodes a 15-domain serine proteinase inhibitor, disulfide bonds are important for LEKTI function, noncompetitive mechanism, expression and purification of human LEKTI gene in Sf9
Li+
-
10 mM, 19% inhibition
lily bulb trypsin inhibitor
-
-
-
Lima bean trypsin inhibitor
-
Locusta migratoria protease inhibitor 1
-
strong inhibition
-
Locusta migratoria protease inhibitor 3
-
strong inhibition, the inhibitor interacts with trypsin through the reactive site P3-P4' and the P10-P6 residues
-
low-molecular-mass trypsin inhibitor inhibitor type-2
-
from Sinapis alba, inhibitor consists of a peptide mixture, displaying Ile or Arg at position 43, Trp or kynurenine at position 44, and C-terminal ragged ends
-
m-amidinosalicylidene-L-alaninato(aqua)copper(II)
-
-
m-amidinosalicylidene-L-alaninato(aqua)copper(II) hydrochloride
-
-
-
m-guanidinosalicylidene-L-alaninato(aqua)copper(II)
-
-
mung bean trypsin inhibitor
-
mustard trypsin inhibitor 2
-
mustard trypsin inhibitor II
inhibition of HzTrypsin-C, no inhibition of HzTrypsin-S
-
N-alpha-p-tosyl-L-lysine chloromethyl ketone
N-alpha-tosyl-L-Lys-chloromethyl ketone
-
complete inhibition at 1 mM
N-alpha-tosyl-L-lysine chlormethylketone
-
less than 50% inhibition of isozyme TryIII by the trypsin-specific inhibitor N-alpha-tosyl-L-lysine chlormethylketone
N-alpha-tosyl-L-lysine chloromethyl ketone
-
-
N-alpha-tosyl-L-lysine-chloromethylketone
-
complete inhibition at 5 mM
N-p-tosyl-L-lysine chloromethyl ketone
N-p-tosyl-lysine chloroketone
N-tosyl-L-lysine chloromethyl ketone
82.9% inhibition at 5 mM
N-tosyl-L-lysine-chloromethyl ketone
N-tosyl-L-phenyl-alanine-chloromethyl ketone
-
11% inhibition at 1mg/ml
N-tosyl-L-phenylalanine-chloromethyl ketone
-
5.34% inhibition at 5 mM
Na+
-
10 mM, 21% inhibition
Na-p-tosyl-L-lysine chloromethyl ketone hydrochloride
-
inhibits trypsin specifically and irreversibly, 40% reduced activity in the presence of 1 mM Na-p-tosyl-L-lysine chloromethyl ketone hydrochloride
Nafamostat
-
potent inhibitor
nafamostat mesilate
IC50: 0.00003 mM
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-4'-acetyl-piperazide
-
-
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-4'-methylpiperidide
-
-
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-D-pipecolic acid
-
-
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-D-pipecolic acid methyl ester
-
-
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-isopecotinic acid
-
-
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-isopecotinic acid methylester
-
-
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-piperazide
-
-
Nalpha-p-tosyl-L-lysine chloromethyl ketone
-
complete inhibition
Nalpha-tosyl-L-Lys-chloromethyl ketone
Nalpha-tosyl-L-Lys-chloromethylketone
Nalpha-tosylglycyl-3-amidino-DL-phenylalanine-methyl ester
-
-
napsagatran ethylester
-
-
nexin-1
-
nexin-1 inhibits isozymes trypsin-1 ad trypsin-2, nexin-1 inhibits trypsin-4 and forms stable complexes only with this trypsin isoenzyme
-
p-amidinosalicylidene-L-alaninato(aqua)copper(II)
-
-
p-nitrophenyl-p'-guanidino-benzoate
-
irreversible trypsin inhibitor
p-tosyl-L-Lys-chloromethane
pancreatic secretory trypsin inhibitor
-
Pancreatic trypsin inhibitor
-
pepstatin A
26% inhibition at 0.01 mM
Phaseolus vulgaris trypsin inhibitor
-
two different variants of 132 kDa and 118 kDA from navy beans and red kidney beans, respectively, isolated by heat treatment and ammonium sulfate fractionation
-
phenyl methyl sulphonyl fluoride
-
100% inhibition
phenylmethyl sulfonyl fluoride
phenylmethylsulfonyl fluoride
Phenylmethylsulfonylfluoride
Plathymenia foliolosa trypsin inhibitor
-
PFTI
-
polylysine
-
immobilized enzyme
porcine secretory inhibitors
-
-
-
porcine trypsin inhibitor
-
0.01 mM, more than 95% inhibition
-
potato inhibitor II
strong inhibition of HzTrypsin-C, no inhibition of HzTrypsin-S
-
Protease Inhibitor Cocktail
-
-
-
Putranjiva roxburghii trypsin inhibitor
-
highly potent inhibitor of bovine trypsin, trypsin inhibitory activity of Putranjiva roxburghii trypsin inhibitor is completely retained up to 70°C, above 70°C, there is a slight decrease in the inhibitory activity retaining almost 85% inhibitory activity up to 80°C, the inhibitory activity of Putranjiva roxburghii trypsin inhibitor falls sharply above 80°C with a loss of almost 80% inhibitory activity at 90°C, only a slight decrease of 5% in inhibitory activity is observed when Putranjiva roxburghii trypsin inhibitor is incubated for 2 h at 100 mM dithiothreitol
-
Sagittaria sagittifolia arrowhead protease inhibitor A
-
API-A
-
small glossy black soybean trypsin inhibitor
-
inhibitory activity is stable in the pH range 3-13 and in the temperature range 0-60°C, is inhibited by dithiothreitol (5-25 mM) in a dose-dependent manner
-
sodium dodecylsulfate
-
0.5% w/v, no residual activity
soybean Bowman-Birk inhibitor
inhibition of HzTrypsin-C,no inhibition of HzTrypsin-S
-
soybean Kunitz trypsin inhibitor
-
Soybean trypsin inhibitor
-
Spinacia oleracea trypsin inhibitor
-
high affinity between trypsin and Spinacia oleracea trypsin inhibitor
-
sun flower trypsin inhibitor-1
-
-
sunflower trypsin inhibitor 1
-
SFTI-1, binding and effects on human prostate cancer cells, overview
sunflower trypsin inhibitor-1
SVIGCWTKSIPPRPCFVK-amide
-
HV-BBI is a Bowman-Birk type protease inhibitor from the skin secretion of the Chinese Bamboo odorous frog Huia versabilis, SVIGCWTKSIPPRPCFVK-amide is a synthetic replicate of HV-BBI with the wild-type K (Lys8) residue in the presumed P1 position and is a potent, competitive, and reversible inhibitor of trypsin
SVIGCWTRSIPPRPCFVK-amide
-
HV-BBI is a Bowman-Birk type protease inhibitor from the skin secretion of the Chinese Bamboo odorous frog Huia versabilis, SVIGCWTRSIPPRPCFVK-amide is a synthetic replicate of HV-BBI with the mutant R (Arg8) residue in the presumed P1 position and is a competitive, and reversible inhibitor of trypsin with reduced potency compared to the wild type peptide SVIGCWTKSIPPRPCFVK-amide
T5E/N18R/T20G/P21S/T22D/K31M mutant Schistocerca gregaria protease (trypsin) inhibitor 1
-
the mutant inhibitor is improved compared to the wild-type inhibitor protein
-
Tamarindus indica trypsin inhibitor
-
a Kunitz-type inhibitor
-
thionine
-
from cowpea, inhibits trypsin, no inhibition of chymotrypsin
tissue inhibitor of matrix metalloproteinases-2
-
TIMP-2, prevents the C-terminal truncation of activated metalloproteinase-2, without affecting the generation of the initial 62 kDa activated species
-
tosyl-L-lysine-chloromethyl ketone
-
-
tosyl-L-lysyl chloromethyl ketone
tosyl-L-Phe chloromethyl ketone
-
-
trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane
-
-
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
-
trypsin inhibitor I-S Type from soybean
-
reversible trypsin inhibitor
-
trypsin modulating oostatic factor
-
the hexapeptide NPTNLH is secreted at the last stage of vitellogenesis and inhibits the biosynthesis of trypsin in insect midgut cells
-
tumor-associated trypsin inhibitor
-
urinary trypsin inhibitor
-
Vigna angularis trypsin inhibitor
-
from adzuki beans, 13 kDa, isolated by heat treatment and ammonium sulfate fractionation
-
Vigna mungo trypsin inhibitor
-
purification of the Bowman-Birk proteinase inhibitor from the seeds of black gram, Vigna mungo cv. TAU-1. 8041.5 Da by mass spectrometry, pI 4.3-6.0, stable up to 80°C and at pH 2.0-12.0, analysis of the secondary structural conformation, overview, exhibts non-competitive-type inhibitory activity against both bovine pancreatic trypsin
-
wild-type soybean inhibitor
-
WBTI
-
[4-(6-chloro-naphthalene-2-sulphonyl)piperazin-1-yl]-(3,4,5,6-tetrahydro-[2H-1,4']bipyridinyl-4-yl)-methanone
-
-
[Abu(3, 11)]-sun flower trypsin inhibitor-1
-
-
-
[Arg5]-SFTI-1
-
a wild-type SFTI-1 analogue
[Lys5]-SFTI-1
-
a wild-type SFTI-1 analogue
[N,N'-bis(m-amidinosalicylidene)ethylenediaminato]copper(II)
-
-
-
[N,N'-bis(m-guanidinosalicylidene)ethylenediaminato]copper(II)
-
-
-
[Phe5]-SFTI-1
-
a wild-type SFTI-1 analogue
1-(L-trans-epoxysuccinyl-leucylamino)-4-guanidinobutane
16.9% inhibition at 0.1 mM
1-(L-trans-epoxysuccinyl-leucylamino)-4-guanidinobutane
-
6.09% inhibition at 0.1 mM
Adenanthera pavonina trypsin inhibitor
-
i.e. ApTI, isolated and purified from seeds, retards larval and pupal developmental and growth of larvae of Anticarsia gemmatalis, overview
-
Adenanthera pavonina trypsin inhibitor
-
i.e. ApTI, isolated and purified from seeds, retards larval and pupal developmental and growth of Corcyra cephalonica, overview
-
Adenanthera pavonina trypsin inhibitor
-
i.e. ApTI, isolated and purified from seeds, retards larval and pupal developmental and growth of Diatraea saccharalis, overview
-
Adenanthera pavonina trypsin inhibitor
-
i.e. ApTI, isolated and purified from seeds, retards larval and pupal developmental and growth of Anagasta kuehniella, a severe pest in flour mills, at 1% with a significant reduction in larval survival and weight, effects of this inhibitor on food consumption, absorption and utilization, as well as the effects of the inhibitor on the midgut proteolytic activity of larvae fed on an artificial diet, overview
-
Adenanthera pavonina trypsin inhibitor
-
i.e. ApTI, isolated and purified from seeds, has only slight retarding effect on larval and pupal developmental and growth of Sitotroga cerealella, overview
-
Adenanthera pavonina trypsin inhibitor
-
i.e. ApTI, isolated and purified from seeds, retards larval and pupal developmental and growth of Spodoptera frugiperda, overview
-
antipain
IC50: 0.04 mM
antipain
-
0.01 mM, isoenzyme aT-I loses 96% of its activity, isoenzyme aT-II loses 99% of its activity
Aprotinin
-
-
Aprotinin
-
immobilized enzyme
Aprotinin
-
very efficient inhibition of trypsin-1 and trypsin-2, but not of trypsin-4
Ba2+
-
-
Ba2+
-
27% inhibition at 5 mM
benzamidine
-
unspecific, weak inhibition
benzamidine
-
competitive inhibitor
benzamidine
5 mM, 17.9% residual activity
benzamidine
-
99% inhibition at 1 mM
benzamidine
-
1 mM, isoenzyme aT-I loses 90% of its activity, isoenzyme aT-II loses 93% of its activity
benzamidine
-
72.0% inhibition of trypsin A, 95.4% of trypsin B, at 1 mM. 88.8% inhibition of trypsin A, 97.6% of trypsin B at 0.1 mM,
benzamidine
-
54% inhibition at 5 mM
benzamidine
-
5 mM, 22% residual activity
benzamidine
-
80.2% inhibition
benzamidine
-
complete inhibition
benzamidine
-
55% inhibition at 5 mM
benzylamine
-
-
Bovine pancreatic trypsin inhibitor
-
-
-
Bovine pancreatic trypsin inhibitor
-
BPTI
-
Bovine pancreatic trypsin inhibitor
-
-
-
Bovine pancreatic trypsin inhibitor
-
i.e. BPTI or aprotinin, influence of temperature on the relationship between structure and dynamics of the inhibitor protein, calculations and X-ray crystal structure of BPTI at 1.5 A resolution, global diffusion and internal motions, overview
-
Bovine pancreatic trypsin inhibitor
-
BPTI, a natural non-specific serine protease inhibitor which possesses the ability to inhibit trypsin, the inhibitory activity of recombinant BPTI against trypsin is the same as natural BPTI, the trade name is aprotinin
-
Bovine pancreatic trypsin inhibitor
-
also known as aprotinin. At the lowest aprotinin concentration of 0.000625 mg, the residual trypsin obtained in neonate larvae of shoot borer, internode borer and top borer is 33.6, 24.8 and 9.3%, respectively. The residual trypsin for third instar of shoot borer, internode borer and top borer at the lowest aprotinin concentration of 0.000125 mg is 55.0, 65.0 and 20.7%, respectively. The amount of aprotinin needed to bring about 50% inhibition of gut proteinases of third instar larvae is 0.00025 mg for shoot borer and 0.0025 mg for internode borer whereas 0.000125 mg is sufficient to bring about nearly 80% inhibition in top borer.
-
Bowman-Birk inhibitor
-
double-headed native trypsin/chymotrypsin inhibitor in soybeans, which inhibits trypsin and chymotrypsin in a non-competitive manner, 78% reduced activity in the presence of 0.0005 mM Bowman-Birk inhibitor
Bowman-Birk inhibitor
-
-
chymostatin
-
-
Co2+
-
10 mM, 31.6% inhibition
Co2+
-
48% inhibition at 5 mM
Cu2+
-
14% inhibition at 5 mM
Cu2+
-
68% inhibition at 5 mM
DFP
-
-
E-64
0.02 mM, 19.5% residual activity
E-64
-
18.3% inhibition of trypsin A, 11.1% of trypsin B, at 0.001 mM. 46.9% inhibition of trypsin A, 33.8% of trypsin B at 0.01 mM
EDTA
-
10% inhibition at 2 mM
EDTA
-
12% inhibition at 5 mM
EDTA
-
weak inhibition, 18% inhibition at 10 mM
EDTA
14.2% inhibition at 2 mM
EDTA
-
50 mM, 88% residual activity
EDTA
-
1 mM, 53.9% residual activity
EDTA
-
6.85% inhibition at 2 mM
EDTA
-
a metalloenzyme inhibitor, 8% inhibition at 5 mM
Hg2+
-
57% inhibition at 5 mM
Hg2+
-
72% inhibition at 5 mM
Hg2+
-
10 mM, 85.7% inhibition
leupeptin
IC50: 0.0002 mM
leupeptin
-
0.1 mM, isoenzyme aT-I loses 97% of its activity, isoenzyme aT-II completely loses its activity
Lima bean trypsin inhibitor
0.002 mM, 7.9% residual activity
-
Lima bean trypsin inhibitor
-
-
-
Lima bean trypsin inhibitor
-
-
-
Mg2+
-
24% inhibition at 5 mM
Mg2+
-
10 mM, 21.6% inhibition
Mn2+
-
-
Mn2+
-
34.5% inhibition at 5 mM
mung bean trypsin inhibitor
-
synthesis and inhibitory activity of mutant inhibitor variants expressed in Escherichia coli, overview
-
mung bean trypsin inhibitor
0.003 mM, 3.6% residual activity
-
mustard trypsin inhibitor 2
-
-
-
mustard trypsin inhibitor 2
-
80% of trypsin activity can be inhibited by 42 nM mustard trypsin inhibitor 2
-
N-alpha-p-tosyl-L-lysine chloromethyl ketone
-
10 mM, 99.67% inhibition
N-alpha-p-tosyl-L-lysine chloromethyl ketone
-
85.4% inhibition
N-p-tosyl-L-lysine chloromethyl ketone
5 mM, 83% inhibition
N-p-tosyl-L-lysine chloromethyl ketone
-
88% inhibition at 5 mM
N-p-tosyl-L-lysine chloromethyl ketone
-
89% inhibition at 0.1 mM
N-p-tosyl-L-lysine chloromethyl ketone
-
complete inhibition at 5 mM
N-p-tosyl-lysine chloroketone
-
-
N-p-tosyl-lysine chloroketone
-
-
N-p-tosyl-lysine chloroketone
-
-
N-p-tosyl-lysine chloroketone
-
-
N-tosyl-L-lysine-chloromethyl ketone
-
82% inhibition at 5 mM
N-tosyl-L-lysine-chloromethyl ketone
-
complete inhibition
NaCl
-
enzyme activity continuously decreases with increasing NaCl concentration of 0-30%
NaCl
-
60& inhibition at 35% NaCl
NaCl
69% inhibition at 0.6 M
NaCl
-
enzyme activity continuously decreases to 50% of maximal activity with increasing NaCl concentration of 0-30%
NaCl
-
trypsin activity decreases continuously as NaCl concentration increases from 030%
NaCl
-
exhibits a progressive decrease in activity with increasing NaCl concentration (0-30%)
NaCl
-
relative activities of trypsin isozymes A, B, and C at 15% NaCl are approximately 39%, 38% and 40% of maximal activity, respectively
NaCl
-
60% inhibition at 30% NaCl
NaCl
-
activity decreases with increasing NaCl concentrations (0-30%)
Nalpha-tosyl-L-Lys-chloromethyl ketone
-
91% inhibition at 1 mM
Nalpha-tosyl-L-Lys-chloromethyl ketone
-
-
Nalpha-tosyl-L-Lys-chloromethyl ketone
-
-
Nalpha-tosyl-L-Lys-chloromethyl ketone
-
-
Nalpha-tosyl-L-Lys-chloromethyl ketone
-
-
Nalpha-tosyl-L-Lys-chloromethylketone
-
79% inhibition at 5 mM
Nalpha-tosyl-L-Lys-chloromethylketone
-
89% inhibition at 5 mM
Nalpha-tosyl-L-Lys-chloromethylketone
-
-
ovomucoid
-
-
-
ovomucoid
-
chicken ovomucoid
-
p-tosyl-L-Lys-chloromethane
-
-
p-tosyl-L-Lys-chloromethane
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reaction towards B chain of insulin is inhibited, the activity towards the A-chain is not significantly affected
pancreatic secretory trypsin inhibitor
-
a Kazal-type specific trypsin inhibitor with narrow specificity for the inhibition of trypsin, with very little or no inhibitory capacity against other serine proteinases, even those exhibiting trypsin-like specificity
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pancreatic secretory trypsin inhibitor
-
also known as serine protease inhibitor Kazal type 1
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Pancreatic trypsin inhibitor
-
i.e. trasylol, kallikrein inactivator
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Pancreatic trypsin inhibitor
-
bovine pancreatic trypsin inhibitor
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PdKI-3.1
-
isolation of two highly pH- and thermo-stable Kunitz-type inhibitors of trypsin from seeds of the tree Pithecellobium dumosum, overview
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PdKI-3.1
-
isolation of two highly pH- and thermo-stable Kunitz-type inhibitors of trypsin from seeds of the tree Pithecellobium dumosum, overview
-
PdKI-3.1
-
isolation of two highly pH- and thermo-stable Kunitz-type inhibitors of trypsin from seeds of the tree Pithecellobium dumosum, overview
-
PdKI-3.2
-
isolation of two highly pH- and thermo-stable Kunitz-type inhibitors of trypsin from seeds of the tree Pithecellobium dumosum, overview
-
PdKI-3.2
-
isolation of two highly pH- and thermo-stable Kunitz-type inhibitors of trypsin from seeds of the tree Pithecellobium dumosum, overview
-
PdKI-3.2
-
isolation of two highly pH- and thermo-stable Kunitz-type inhibitors of trypsin from seeds of the tree Pithecellobium dumosum, overview
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Pefabloc SC
1 mM, 4.5% residual activity
Pefabloc SC
-
completely inhibits isoenzymes trypsin-1, trypsin-2, and trypsin-4
Pefabloc SC
-
complete inhibition of trypsin A and B at 1 mM
phenylbutylamine
-
-
phenylbutylamine
salmon
-
-
Phenylethylamine
-
-
Phenylethylamine
salmon
-
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phenylmethyl sulfonyl fluoride
-
-
phenylmethyl sulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
10 mM, 4.5% residual activity
phenylmethylsulfonyl fluoride
-
100 mM, complete inhibition
phenylmethylsulfonyl fluoride
-
5 mM, 43% residual activity
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
a serine protease inhibitor, over 90% inhibition of trypsin isozymes A, B and C at 5 mM
phenylmethylsulfonyl fluoride
-
partial
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
-
Phenylmethylsulfonylfluoride
-
89.5% inhibition at 1 mM
Phenylmethylsulfonylfluoride
-
-
Phenylpropylamine
-
-
Phenylpropylamine
salmon
-
-
PMSF
-
80% inhibition at 1 mM, complete at 5 mM
PMSF
-
62% inhibition at 1 mM, complete inhibition at 5 mM
PMSF
-
73% inhibition at 1 mM
PMSF
-
0.1 mM, isoenzyme aT-I loses 89% of its activity, isoenzyme aT-II loses 80% of its activity
PMSF
-
80.7% inhibition of trypsin A, 57.4% of trypsin B at 0.1 mM. 96.4% inhibition of trypsin A, 93.2% of trypsin B at 1 mM
PMSF
-
89% inhibition at 5 mM
PMSF
-
complete inhibition
PMSF
-
61% inhibition at 1 mM, complete inhibition at 5 mM
soybean Kunitz trypsin inhibitor
-
-
-
soybean Kunitz trypsin inhibitor
strong inhibition of HzTrypsin-C, no inhibition of HzTrypsin-S
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soybean Kunitz trypsin inhibitor
-
80% of trypsin activity can be inhibited by 42 nM soybean Kunitz trypsin inhibitor
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Soybean trypsin inhibitor
-
complete inhibition at 1 mg/ml
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Soybean trypsin inhibitor
-
complete inhibition at 1 mg/ml
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Soybean trypsin inhibitor
-
complete inhibition at 1 mg/ml
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Soybean trypsin inhibitor
IC50: 0.000009 mM
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Soybean trypsin inhibitor
-
-
-
Soybean trypsin inhibitor
-
different Kunitz trypsin inhibitors, KTIs, from different soybean lines, 15 soybean experimental lines and varieties, overview
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Soybean trypsin inhibitor
-
isozyme TryIII activity is completely (more than 95%) inhibited by soybean trypsin inhibitor
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Soybean trypsin inhibitor
-
-
-
Soybean trypsin inhibitor
-
250 mM, complete inhibition
-
Soybean trypsin inhibitor
-
84% inhibition at 1 mg/ml
-
Soybean trypsin inhibitor
-
0.1 mg/ml, isoenzyme aT-I loses 95% of its activity, isoenzyme aT-II loses 97% of its activity
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Soybean trypsin inhibitor
1 mg/ml, 80% inhibition; 80.3% inhibition at 1 mg/ml
-
Soybean trypsin inhibitor
-
91% inhibition at 1mg/ml
-
Soybean trypsin inhibitor
-
80% inhibition at 1 mg/ml
-
Soybean trypsin inhibitor
-
-
-
Soybean trypsin inhibitor
-
-
-
Soybean trypsin inhibitor
-
complete inhibition at 1 mg/ml
-
Soybean trypsin inhibitor
-
-
-
Soybean trypsin inhibitor
-
91.5% inhibition at 1 mg/ml
-
Soybean trypsin inhibitor
-
complete inhibition
-
Soybean trypsin inhibitor
-
0.025% w/v, 0.3% residual activity
-
Soybean trypsin inhibitor
-
-
-
Soybean trypsin inhibitor
-
-
-
Soybean trypsin inhibitor
-
96% inhibition at 1 mM
-
Soybean trypsin inhibitor
-
75.6% inhibition
-
Soybean trypsin inhibitor
-
-
-
Soybean trypsin inhibitor
-
-
-
Soybean trypsin inhibitor
-
-
Soybean trypsin inhibitor
-
84.2% inhibition at 1 mg/ml
-
Soybean trypsin inhibitor
-
a serine protease inhibitor, complete inhibition of trypsin isozymes A, B and C at 1 mg/ml
-
Soybean trypsin inhibitor
-
complete inhibition
-
Soybean trypsin inhibitor
-
0.01 mM, more than 95% inhibition
-
Soybean trypsin inhibitor
-
SBT, complete inhibition at 1 mg/ml
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Soybean trypsin inhibitor
-
-
-
Soybean trypsin inhibitor
-
-
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Soybean trypsin inhibitor
-
a Kunitz trypsin inhibitor from soybean seeds, identification of mutants, several polymorphic types that are controlled by multiple alleles, overview. Development of a single nucleotide amplified polymorphism marker for the classification of the predominant KTi types, Tia and Tib, and evaluation of KTi activities by differing KTi type total 451 soybean mutant lines, overview. Trypsin inhibitor type and trypsin inhibitor activity in TIU/mg, overview
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Soybean trypsin inhibitor
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effective inhibitor
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Soybean trypsin inhibitor
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strong
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Soybean trypsin inhibitor
-
-
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sunflower trypsin inhibitor-1
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SFTI-1
sunflower trypsin inhibitor-1
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SFTI-1, a natural 14-residue cyclic peptide, can be used for enzyme separation from other serine proteases, synthesis of SFTI-1-based supports and affinity chromatography, overview. Inhibition of trypsin by some acyclic SFTI-1 analogues, e.g. [Lys5]-SFTI-1, [Arg5]-SFTI-1, and [Phe5]-SFTI-1, no inhibition by [Leu5]-SFTI-1, overview
tosyl-L-lysyl chloromethyl ketone
-
-
tosyl-L-lysyl chloromethyl ketone
-
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tosyl-L-lysyl chloromethyl ketone
-
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tosyl-L-lysyl chloromethyl ketone
-
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tosyl-L-lysyl chloromethyl ketone
Triops sp.
-
-
tumor-associated trypsin inhibitor
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specific inhibition of degradation of gelatin and collagen type II
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tumor-associated trypsin inhibitor
-
specific inhibition of degradation of gelatin and collagen type II
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tumor-associated trypsin inhibitor
-
very efficient inhibition of trypsin-1 and trypsin-2, but not of trypsin-4
-
tumor-associated trypsin inhibitor
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i.e. TATI, endogenous inhjibitor expressed in the cytoplasm of colon mucosa and colorectal cancer cells, shows prognostic significance of tumour-specific TATI expression in colorectal cancer, inhibitor expression is associated with a significantly decreased overall survival of colon cancer patients, and with increased liver metastasis, overview
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urinary trypsin inhibitor
-
also known as ulinastatin
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urinary trypsin inhibitor
-
urinary trypsin inhibitor reduces nuclear factor-kappa B activation and downregulates the expression of its related mediators, followed by the inhibition of neutrophil aggregation and infiltration in hepatic ischemiareperfusion injury
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urinary trypsin inhibitor
-
-
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urinary trypsin inhibitor
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also known as bikunin
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urinary trypsin inhibitor
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-
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urinary trypsin inhibitor
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a Kunitz type protease inhibitor
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Zn2+
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18% inhibition at 5 mM
Zn2+
-
10 mM, 31.6% inhibition
Zn2+
-
71% inhibition at 5 mM
additional information
-
no inhibition by E-64, N-ethylmaleimide, iodoacetic acid, pepstatin A, and Nalpha-4-tosyl-L-Phe-chloromethylketone
-
additional information
-
the enzyme activity is completely stable in presence of detergents, overview. No inhibition by EDTA, 2-nercaptoethanol, pepstatin A, Ca2+, Ba2+, Zn2+, Cu2+, Mg2+, Mn2+, K+, and Na+
-
additional information
-
no or poor inhibition by pepstatin A, 2-mercaptoethanol, Ca2+, K+, and Na+
-
additional information
-
naturally occurring trypsin inhibitor SFTI-1 isolated from sunflower seeds and its analogues
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additional information
-
4-guanidinebenzoate: no inhibition up to 0.2 mM
-
additional information
-
trypsin is not inhibited by N-(4-aminobutyl)-L-Arg-L-Cys-L-Thr-L-Lys-L-Ser-L-Ile-L-Pro-L-Pro-L-Ile-L-Cys-L-Phe-L-Pro-L-Asp and N-benzylglycine-L-Arg-L-Cys-L-Thr-L-Lys-L-Ser-L-Ile-L-Pro-L-Pro-L-Ile-L-Cys-L-Phe-L-Pro-L-Asp
-
additional information
-
trypsin is not inhibited by N-(4-aminobutyl)-L-Arg-L-Cys-L-Thr-L-Lys-L-Ser-L-Ile-L-Pro-L-Pro-L-Ile-L-Cys-L-Phe-L-Pro-L-Asp and N-benzylglycine-L-Arg-L-Cys-L-Thr-L-Lys-L-Ser-L-Ile-L-Pro-L-Pro-L-Ile-L-Cys-L-Phe-L-Pro-L-Asp, Gly-L-Arg-(2-amino butanoic acid)-L-Thr-Nlys-L-Ser-L-Ile-L-Pro-L-Pro-L-Ile-(2-amino butanoyl)-L-Phe-L-Pro-L-Asp, L-Lys-(2-amino butanoyl)-L-Thr-Nlys-L-Ser-L-Ile-L-Pro-L-Pro-L-Ile-(2-amino butanoyl)-L-Phe-L-Pro-L-Asp, and Nlys-(2-amino butanoyl)-L-Thr-Nlys-L-Ser-L-Ile-L-Pro-L-Pro-L-Ile-(2-amino butanoyl)-L-Phe-L-Pro-L-Asp
-
additional information
-
design and synthesis of Schiff base metal chelate inhibitors of trypsin, structural basis, overview. The binding mode of the guanidino groups of m-guanidinosalicylidene-L-alaninato(aqua)copper(II) hydrochloride and [N,N'-bis(m-guanidinosalicylidene)ethylenediaminato]copper(II) to Asp189 in the S1 pocket of trypsin is markedly different from of the amidino group of m-amidinosalicylidene-L-alaninato(aqua)copper(II) hydrochloride. The active site residues of trypsin play a crucial role in the binding affinity to the trypsin molecule.
-
additional information
-
inhinitory potencies of the different legume trypsin inhibitors, overview
-
additional information
-
aspartate (PepA) and cysteine (E64) protease inhibitors as well as the chymotrypsin inhibitor tosyl-L-phenylalanine chloromethylketone have no effect on enzymatic activity of isozyme TryIII
-
additional information
-
no inhibition by N-alpha-tosyl-L-Phe-chloromethyl ketone, E-64, and O-fenantroline
-
additional information
-
not inhibitory: chymostatin
-
additional information
-
the crude and partially purified extract from Passiflora f. edulis flavicarpa leaves displays inhibitory effect towards trypsin, methyl jasmonate treatment of the leaves increases the inhibitory activity against trypsin
-
additional information
-
no or poor inhibition by E-64, N-ethylmaleimide, iodoacetic acid, TPCK, pepstatin A, and EDTA
-
additional information
-
no inhibition by N-ethylmaleimide
-
additional information
no inhibition by N-ethylmaleimide
-
additional information
-
1-(L-trans-epoxysuccinyl-leucylamino)-4-guanidinobutane, N-ethylmaleimide, iodoacetic acid, chymotrypsin, pepstatin A, and EDTA have no inhibitory effect
-
additional information
-
no or poor inhibition by E-64, N-ethylmaleimide, iodoacetic acid, TPCK, pepstatin A, and EDTA
-
additional information
-
trypsin 4 is completely resistant to chymotryptic degradation
-
additional information
-
mesotrypsin exhibits complete resistance against wild-type alpha1-antitrypsin
-
additional information
-
resistant to soybean trypsin inhibitor and aprotinin
-
additional information
-
trypsin activity decreases with age, trypsin activity correlates inversely with cholesterol concentration and plasmin and elastase activity
-
additional information
-
not inhibited by up to 0.05 mM SVIGCWTFSIPPRPCFVK-amide
-
additional information
-
identification of trypsin-3 binding peptides, and molecular modeling of the binding of peptides to isozyme trypsin-3. The degradation rate of peptides by trypsin correlates to their inhibitory efficacy, the most stable peptides being the most effective inhibitors, overview
-
additional information
-
determination of serum trypsin inhibitory capacity of plasma in psoriatic patients, which is increased compared to healthy persons
-
additional information
-
no or poor inhibition of trypsin A and trypsin B by pepstatin at 0.001 mM, and EDTA and 1,10-phenathroline at 10 mM
-
additional information
-
no or poor inhibition by N-tosyl-L-phenylalanine chloromethylketone, EDTA, 2-mercaptoethanol, pepstatin A, iodoacetic acid, and E-64
-
additional information
-
infection of Lutzomyia longipalpis with Leishmania mexicana reduces trypsin-like activity in the sand fly midgut, overview
-
additional information
-
no or poor inhibition by pepstatin A, EDTA, 2-mercaptoethanol, and N-p-tosyl-L-phenylalanine chloromethyl ketone
-
additional information
-
no inhibition by EDTA, E-64, and pepstatin A
-
additional information
-
not inhibitory: Ca2+ up to 500 mM
-
additional information
-
resistant to soybean trypsin inhibitor and aprotinin
-
additional information
-
effective inhibition of the catalytic activity by metal ions observed in trypsin R96H is caused by specific and reversible reorganization of the active site in the enzyme
-
additional information
-
notinhibited by pepstatin A
-
additional information
-
no inhibition by DTNB and 2-mercaptoethanol
-
additional information
-
not inhibitory: EDTA, tosyl-L-Phe chloromethyl ketone
-
additional information
-
no inhibition by pepstatin A, 2-mercaptoethanol and EDTA
-
additional information
-
not inhibited by 1-(L-trans-epoxysuccinyl-leucylamino)-4-guanidinobutane, N-ethylmaleimide, iodoacetic acid, N-tosyl-L-phenyl-alanine-chloromethyl ketone, and pepstatin
-