3.4.21.4: trypsin

This is an abbreviated version!
For detailed information about trypsin, go to the full flat file.

Reaction

preferential cleavage: Arg-/-, Lys-/- =

Synonyms

acrosin, alpha-trypsin, anionic salmon trypsin, anionic trypsin, Anionic trypsinogen, AST, aT-I, aT-II, Atlantic cod trypsin I, beta-trypsin, BPT, Brain trypsinogen, BT, cationic trypsin, Cationic trypsinogen, cocoonase, CST, EC 3.4.4.4, EFE, EG-T, fibrinolytic enzyme, gamma-trypsin, GM-T, group III trypsin, mesotrypsin, Mesotrypsinogen, midgut-specific serine protease 1, midgut-specific serine protease 2, More, p23, parenzyme, parenzymol, PPT, pro23, pseudotrypsin, SET, SGT, sperm receptor hydrolase, ST-1, ST-2, ST-3, TI, TIIA, TIII, TLE, TLE I, TLE II, TR-P, TR-S, tripcellim, TRP, Try, TRY-3, TryI, TryII, TryIII, TRYP, trypsin 1, trypsin 3A1, trypsin 4, trypsin A, trypsin B, trypsin I, trypsin IV, trypsin type III, trypsin Y, trypsin-1, trypsin-2, trypsin-3, trypsin-4, trypsin-like enzyme, trypsin-like serine proteinase, tryptar, tryptase, trypure, TrypZean, type I trypsin, type IX pancreatic trypsin

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.4 trypsin

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Results	in table
18	Activating Compound
676	AA Sequence
20	Application
1	CAS Registry Number
24	Cloned(Commentary)
38	Crystallization (Commentary)
12526	Disease/ Diagnostics
1	Expression
20	General Information
28	General Stability
9	IC50 Value
419	Inhibitors
64	kcat/KM [mM/s]
70	Ki Value [mM]
400	KM Value [mM]
3	Localization
34	Metals/Ions
92	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
8	Organic Solvent Stability
308	Organism
1	Oxidation Stability
1	Pathway
853	PDB ID
90	pH Optimum
27	pH Range
41	pH Stability
17	pI Value
18	Posttranslational Modification
44	Protein Variants
80	Purification (Commentary)
3	Reaction
2	Reaction Type
306	Reference
3	Renatured (Commentary)
230	Source Tissue
58	Specific Activity [micromol/min/mg]
6	Storage Stability
618	Substrates and Products (Substrate)
51	Subunits
102	Synonyms
69	Temperature Optimum [°C]
19	Temperature Range [°C]
58	Temperature Stability [°C]
375	Turnover Number [1/s]

Organism

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Go back to the abbreviated version
of the Enzyme Summary Page.

Organism on EC 3.4.21.4 - trypsin

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Aedes aegypti

2 entries

Albatrossia pectoralis

-

708835

-

-

brenda

Alces alces

-

95462

-

-

brenda

Anticarsia gemmatalis

-

707290

-

-

brenda

Astacus astacus

-

699194

-

-

brenda

Astacus leptodactylus

-

95434

-

-

brenda

Asterias amurensis

-

699194

-

-

brenda

Balistes capriscus

-

708553

-

-

brenda

Boops boops

-

708530

-

-

brenda

Boreogadus saida

-

717556

D0G7G2

UniProt

brenda

Bos taurus

12 entries

Cambarus affinis

-

95434, 95463

-

-

brenda

Cancer pagurus

-

695989, 699194

-

-

brenda

Canis lupus familiaris

2 entries

Capra hircus

-

698509

-

-

brenda

Ceratitis capitata

-

710488

-

-

brenda

Channa argus

-

731682

G3LUK8

UniProt

brenda

Cirrhinus mrigala

-

731858

-

-

brenda

Colossoma macropomum

-

707407

-

-

brenda

Corcyra cephalonica

-

707290

-

-

brenda

Daphnia magna

-

668324

-

-

brenda

Diaprepes abbreviatus

Sugarcane rootstalk borer weevil

699194

O76498

UniProt

brenda

Diatraea saccharalis

2 entries

Diplodus puntazzo

sharpsnout sea bream

708532

-

-

brenda

Drosophila melanogaster

-

698277

-

-

brenda

Eisenia fetida

isoform EFE-b

669856

-

-

brenda

Eleginus gracilis

-

708552

-

-

brenda

Engraulis japonicus

-

653033

-

-

brenda

Ephestia kuehniella

-

707290

-

-

brenda

Epinephelus coioides

2 entries

Euphausia pacifica

-

678896

-

-

brenda

Felis catus

-

95430

-

-

brenda

Fusarium oxysporum

2 entries

Gadus chalcogrammus

2 entries

Gadus macrocephalus

-

708552

-

-

brenda

Gadus morhua

2 entries

Gallus gallus

-

95438

-

-

brenda

Glossina longipennis

-

95447

-

-

brenda

Helicoverpa zea

2 entries

Homo sapiens

4 entries

Lateolabrax japonicus

-

717516

-

-

brenda

Lepeophtheirus salmonis

putative trypsin

699194

Q7YSS9

UniProt

brenda

Lutjanus guttatus

-

717520

-

-

brenda

Lutjanus vitta

-

708557

-

-

brenda

Lutzomyia longipalpis

-

710193

-

-

brenda

Lycoris radiata

-

668005

-

-

brenda

Lymantria dispar

-

95435

-

-

brenda

Manduca sexta

tobacco hornworm moth

699194

P35045

UniProt

brenda

Mus musculus

-

695500, 698147, 699168, 699942, 699952

-

-

brenda

Musca domestica

-

680151, 699194

-

-

brenda

Mustelus mustelus

-

708852

-

-

brenda

Oncorhynchus keta

2 entries

Oncorhynchus masou

-

708529

-

-

brenda

Oncorhynchus tshawytscha

-

668321

-

-

brenda

Oreochromis niloticus

-

731844

-

-

brenda

Oryctolagus cuniculus

-

95440

-

-

brenda

Oryzias latipes

-

732982

-

-

brenda

Pacifastacus leniusculus

-

95452

-

-

brenda

Paralithodes camtschaticus

-

731840

Q8WR10

UniProt

brenda

Patiria pectinifera

-

650887

-

-

brenda

Penaeus japonicus

-

699194

-

-

brenda

Penaeus paulensis

-

699194

-

-

brenda

Penaeus vannamei

2 entries

Periplaneta americana

-

649587, 680151

-

-

brenda

Pleurogrammus azonus

2 entries

Plodia interpunctella

-

698417, 710488

-

-

brenda

Plutella xylostella

diamondback moth

698283

-

-

brenda

Pterygoplichthys disjunctivus

-

731849

-

-

brenda

Rattus norvegicus

-

95445, 95450, 95451, 95457, 95459, 649322, 652902, 680807, 695479, 696553, 698153, 698505, 699970

-

-

brenda

Rhynchophorus ferrugineus

red palm weevil

699194

-

-

brenda

Rhyzopertha dominica

-

699194

-

-

brenda

Saccharopolyspora erythraea

3 entries

Salmo salar

-

95443, 701304, 731840

-

-

brenda

salmon

-

649162, 653809

-

-

brenda

Sarcophaga bullata

-

699387

-

-

brenda

Sarda sarda

Atlantic bonito

680305

-

-

brenda

Sardinella aurita

trypsin isozymes A, B and C

717612

-

-

brenda

Sardinops caeruleus

-

668318

-

-

brenda

Sardinops melanostictus

isoform TR-S

668694

-

-

brenda

Scirpophaga excerptalis

-

700727

-

-

brenda

Scomberomorus sierra

-

732249

-

-

brenda

Sepia officinalis

-

708550

-

-

brenda

Sesamia nonagrioides

-

681235, 699194

-

-

brenda

Silurus glanis

-

667239

-

-

brenda

Sitophilus zeamais

insecticide-resistant and -susceptible strains, serine proteinases with trypsin-like activity

708221

-

-

brenda

Sitotroga cerealella

-

707290

-

-

brenda

Spodoptera frugiperda

-

707290

-

-

brenda

Spodoptera littoralis

-

695904

-

-

brenda

Stomoxys calcitrans

-

699194

O76519, O76520

UniProt

brenda

Streptomyces griseus

4 entries

Streptomyces omiyaensis

-

717278

-

-

brenda

Sus scrofa

9 entries

Tenebrio molitor

-

680151

-

-

brenda

Thunnus albacares

yellowfin tuna

679341

-

-

brenda

Thunnus tonggol

-

669029

-

-

brenda

Triatoma infestans

-

699194

-

-

brenda

Triops sp.

-

699194

-

-

brenda

Zabrotes subfasciatus

2 entries

Aedes aegypti

-

698289

Q16TL8

UniProt

brenda

Aedes aegypti

-

699194

P29786

UniProt

brenda

Bos taurus

-

95426, 95427, 95431, 95437, 95446, 95449, 95455, 95456, 95458, 95460

-

-

brenda

Bos taurus

-

95461, 649162

P00760

Uniprot

brenda

Bos taurus

-

649574, 649594, 650362, 650440, 650468, 650668, 651085

-

-

brenda

Bos taurus

-

652004

P00760

Uniprot

brenda

Bos taurus

-

652815, 652842, 653035, 653809, 653850, 653985, 667139, 667782, 667978

-

-

brenda

Bos taurus

-

667994

P00760

Uniprot

brenda

Bos taurus

-

668032, 669362, 670043, 677535, 678548, 679658, 679835, 680209, 680256, 680742, 680808, 691248, 694789, 694996, 695341, 695565, 696040, 696371, 696483, 696557, 696590, 696721, 696783, 696811, 697444, 697542, 697553, 698283, 698400, 698513, 699046, 699154, 699161, 699194, 699494, 699735, 699738, 699817, 700665, 700786, 700850, 700952, 701142, 701262, 701270, 707562, 707741, 708498, 708554, 709189, 709263, 709328, 709976, 710243, 717850, 718033

-

-

brenda

Bos taurus

-

731053

P00760

Uniprot

brenda

Bos taurus

-

731343, 731680, 731937

-

-

brenda

Bos taurus

alpha-trypsin and beta-trypsin

95464

-

-

brenda

Bos taurus

calf

708855

-

-

brenda

Bos taurus

isoform beta-trypsin

667386

-

-

brenda

Canis lupus familiaris

-

695083

-

-

brenda

Canis lupus familiaris

a anionic and a cationic trypsin

95442

-

-

brenda

Diatraea saccharalis

-

680151, 699194, 707290

-

-

brenda

Diatraea saccharalis

sugar cane stalk borer

698421

-

-

brenda

Epinephelus coioides

-

717614

-

-

brenda

Epinephelus coioides

-

717614

G9JKF3

UniProt

brenda

Fusarium oxysporum

-

649167, 652472

P35049

Uniprot

brenda

Fusarium oxysporum

-

652872, 667047, 695318

-

-

brenda

Gadus chalcogrammus

-

717556

C4TP29

UniProt

brenda

Gadus chalcogrammus

walleye pollock

679952

-

-

brenda

Gadus morhua

-

95432, 679835, 682658, 708223, 717490

-

-

brenda

Gadus morhua

recombinant enzyme

670753

-

-

brenda

Helicoverpa zea

HzTrypsin-C

651147

Q9NB82

SwissProt

brenda

Helicoverpa zea

HzTrypsin-S

651147

Q9NB82

SwissProt

brenda

Homo sapiens

-

95436, 95453, 95454, 650209, 678332, 679743, 680807, 681538, 681733, 682760, 695428, 695451, 695520, 695996, 696032, 696328, 697021, 697400, 697406, 700007, 700478, 701195, 701375, 707409, 707900, 709306, 709845, 717901, 732138

-

-

brenda

Homo sapiens

isoform trypsin-2

667139

-

-

brenda

Homo sapiens

isozymes trypsin-1, -2, -C and -3

707616

-

-

brenda

Homo sapiens

pancreatic isoforms cationic trypsin, anionic trypsin, and mesotrypsin

668113

-

-

brenda

Oncorhynchus keta

-

652898

Q8AV11

SwissProt

brenda

Oncorhynchus keta

chum salmon

678548

-

-

brenda

Penaeus vannamei

fragment; formerly Penaeus vannamei

699194

Q9TY16

UniProt

brenda

Penaeus vannamei

isoforms A,B,C

668311

-

-

brenda

Pleurogrammus azonus

-

717554

B3IYE4

UniProt

brenda

Pleurogrammus azonus

isoform TR-P

668694

-

-

brenda

Saccharopolyspora erythraea

-

95439

-

-

brenda

Saccharopolyspora erythraea

-

731072

P24664

UniProt

brenda

Saccharopolyspora erythraea

trypsin-like protease; synonym Saccharopolyspora erythraea

699820

Q54137

UniProt

brenda

Streptomyces griseus

-

95433, 95441

-

-

brenda

Streptomyces griseus

-

650230, 667718

P00775

UniProt

brenda

Streptomyces griseus

-

699531, 717278

-

-

brenda

Streptomyces griseus

precursor

677545

P00775

UniProt

brenda

Sus scrofa

-

95428, 95429, 95444, 95448, 649124, 649145, 649362

-

-

brenda

Sus scrofa

-

650242

P00761

Uniprot

brenda

Sus scrofa

-

658338, 669538, 680742, 695698, 697445, 699727, 699820, 699822, 700339, 701270, 701345, 706963, 708047, 710337, 710556, 710597, 731969

-

-

brenda

Sus scrofa

-

732354

P00761

Uniprot

brenda

Sus scrofa

-

732930

-

-

brenda

Sus scrofa

-

752608

P00761

Uniprot

brenda

Sus scrofa

commercial preparation

667154, 669859, 670116

-

-

brenda

Sus scrofa

commercial preparation, modified by supplier using reductive methylation and N-tosyl-Phe chloromethylketone treatment

670852

-

-

brenda

Sus scrofa

type IX, commercial preparation

669689

-

-

brenda

Zabrotes subfasciatus

-

710488

-

-

brenda

Zabrotes subfasciatus

Mexican bean weevil

677842

-

-

brenda