3.4.21.21: coagulation factor VIIa
This is an abbreviated version!
For detailed information about coagulation factor VIIa, go to the full flat file.
Word Map on EC 3.4.21.21
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3.4.21.21
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bleeding
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fibrinogen
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platelet
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viii
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hemostatic
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hemorrhage
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thrombosis
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anticoagulant
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thromboplastin
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plasminogen
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haemophilia
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antithrombin
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coagulopathy
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coronary
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transfusion
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willebrand
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thromboembolic
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trauma
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fibrin
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fibrinolysis
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haemostasis
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d-dimers
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antithrombotic
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warfarin
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hypercoagulable
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intravascular
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pai-1
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off-label
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perioperative
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hematoma
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k-dependent
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amidolytic
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thrombogenic
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antifibrinolytic
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tranexamic
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prothrombotic
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thrombin-antithrombin
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plasma-derived
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drug development
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prothrombinase
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epistaxis
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fondaparinux
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desmopressin
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cryoprecipitate
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thromboelastometry
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dabigatran
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biotechnology
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gamma-carboxyglutamic
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menorrhagia
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apixaban
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thromboelastography
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bethesda
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medicine
- 3.4.21.21
- bleeding
- fibrinogen
- platelet
- viii
-
hemostatic
- hemorrhage
- thrombosis
-
anticoagulant
- thromboplastin
- plasminogen
- haemophilia
- antithrombin
- coagulopathy
- coronary
-
transfusion
- willebrand
-
thromboembolic
- trauma
- fibrin
-
fibrinolysis
-
haemostasis
-
d-dimers
-
antithrombotic
- warfarin
-
hypercoagulable
-
intravascular
- pai-1
-
off-label
-
perioperative
- hematoma
-
k-dependent
-
amidolytic
-
thrombogenic
-
antifibrinolytic
-
tranexamic
-
prothrombotic
-
thrombin-antithrombin
-
plasma-derived
- drug development
- prothrombinase
- epistaxis
- fondaparinux
- desmopressin
-
cryoprecipitate
-
thromboelastometry
- dabigatran
- biotechnology
-
gamma-carboxyglutamic
- menorrhagia
- apixaban
-
thromboelastography
-
bethesda
- medicine
Reaction
Selective cleavage of Arg-/-Ile bond in factor X to form factor Xa =
Synonyms
activated blood coagulation factor VII, activated coagulation factor VII, activated factor VII, blood coagulation factor VIIa, blood-coagulation factor VII, activated, blood-coagulation factor VIIa, coagulation factor VII, coagulation factor VII(a), coagulation FVII, Eptacog alfa, Factor VII, factor VIIa, factor VIIa-sTF, factor VIIa-TF, factor VIIa/tissue factor complex, FIIa, free factor VIIa, FVII, FVIIa, FVIIa-sTF, fVIIa/TF, FVIIc, human factor VIIa + TF, More, NovoSeven, procoagulant protein factor VII, recombinant factor VIIa, recombinant factor-activated VII, rFVII, rFVIIa, serine protease factor VIIa, Serum prothrombin conversion accelerator, soluble tissue factor/factor VIIa complex, sTF/VIIa, TF-FVIIa, TF/VIIa, tissue factor/factor VIIa, tissue factor/factor VIIa complex, vitamin K dependent clotting factor
ECTree
3.4.21.21 coagulation factor VIIaAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.21.21 - coagulation factor VIIa
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Eph tyrosine kinase receptor EphA2 + H2O
?
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cleavage site at the Arg159-His160 bond
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?
Eph tyrosine kinase receptor EphB2 + H2O
?
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cleavage site at the Arg159-His160 bond
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?
factor VIII + H2O
factor VIIIa + ?
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FVIII activity increases about 4-fold within 30 s in the presence of FVIIa/tissue factor. The heavy chain of FVIII is proteolyzed at Arg336. Arg740 and Arg372
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?
factor X + H2O
activated factor X + ?
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the enzyme initiates blood clotting after interacting with its cofactor tissue factor. The product of the reaction, activated factor X, is also the most efficient activator of zymogen factor VII
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?
Factor X + H2O
Factor Xa + ?
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?
Factor X + H2O
Factor Xa + ?
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the enzyme is involved in the coagulation cascade, pathways, overview
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?
protease-activated receptor 2 + H2O
?
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protease-activated receptor 2 is cleaved by FVIIa in the binary tissue factor-FVIIa complex
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?
thrombinogen + H2O
thrombin + ?
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antifibrinolytic effect of the enzyme in relation to the activity of thrombin, regulation, overview
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?
additional information
?
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factor VIIa initiates the coagulation pathway upon complex formation with its cellular receptor and cofactor tissue factor
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?
additional information
?
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blood coagulation is initiated when tissue factor binds to coagulation factor VII to give an enzymatically active complex which then activates factors IX and X, leading to thrombin generation and clot formation
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?
additional information
?
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the enzyme plays a key role in the blood coagulation cascade
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?
additional information
?
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the enzyme plays a key role in the blood coagulation cascade
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?
additional information
?
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cell-surface tissue factor TF binds the serine protease factor VIIa to activate coagulation or, alternatively, to trigger signaling through the G protein-coupled, protease-activated receptor 2 relevant to inflammation and angiogenesis, TF-VIIa-mediated coagulation and cell signaling involve distinct cellular pools of TF, regulation, overview
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?
additional information
?
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membrane binding constitutes a key process in enzymatic activation of various blood coagulation factors
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?
additional information
?
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complex formation with the essential protein cofactor tissue factor
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?
additional information
?
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enzyme blood coagulation activity is regulated in the circadian clock machinery, overview
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?
