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4-methylumbelliferyl 4-guanidinobenzoate + H2O
?
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?
benzoyl-Ile-Glu-gamma-methoxyglutamyl-Gly-Arg-p-nitroanilide + H2O
benzoyl-Ile-Glu-gamma-methoxyglutamyl-Gly-Arg + p-nitroaniline
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i.e. S2222, 2% of the activity with N-methylsulfonyl-D-Phe-Gly-Arg-p-nitroanilide, plasma-derived wild-type enzyme
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?
benzyloxycarbonyl-Arg-p-nitrobenzyl ester + H2O
benzyloxycarbonyl-Arg + 4-nitrophenyl
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?
benzyloxycarbonyl-D-Arg-Gly-Arg + H2O
?
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i.e. S2765, 6% of the activity with N-methylsulfonyl-D-Phe-Gly-Arg-p-nitroanilide, plasma-derived wild-type enzyme
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?
benzyloxycarbonyl-D-Arg-Gly-Arg-4-nitroanilide + H2O
?
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chromogenic S-2765
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?
benzyloxycarbonyl-D-arginyl-D-glycyl-D-arginine-p-nitroanilide + H2O
p-nitroaniline + benzyloxycarbonyl-D-arginyl-D-glycyl-D-arginine
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-
-
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?
benzyloxycarbonyl-D-arginyl-glycyl-arginine-p-nitroanilide + H2O
benzyloxycarbonyl-D-arginyl-glycyl-arginine + p-nitroaniline
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-
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?
benzyloxycarbonyl-D-arginyl-glycyl-L-arginyl-p-nitroanilide + H2O
benzyloxycarbonyl-D-arginyl-glycyl-L-arginine + p-nitroaniline
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?
chromozym t-PA + H2O
?
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?
Chromozym tissue plasminogen activator + H2O
?
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i.e. N-methylsulfonyl-D-Phe-Gly-Arg-4-nitranilide acetate
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?
D-cyclohexylglycyl-L-2-aminobutyryl-L-arginyl-4-nitroanilide + H2O
D-cyclohexylglycyl-L-2-aminobutyryl-L-arginine + 4-nitroaniline
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?
D-Ile-Pro-Arg-4-nitroanilide + H2O
D-Ile-Pro-Arg + 4-nitroaniline
D-Ile-Pro-Arg-p-nitroanilide + H2O
D-Ile-Pro-Arg + p-nitroaniline
D-Ile-Pro-Arg-p-nitroanilide + H2O
p-nitroaniline + D-Ile-Pro-Arg
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?
D-isoleucyl-L-prolyl-L-arginine-p-nitroanilide + H2O
D-isoleucyl-L-prolyl-L-arginine + p-nitroaniline
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-
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?
D-Phe-pipecolyl-Arg-p-nitroanilide + H2O
D-Phe-pipecolyl-Arg + p-nitroaniline
D-phenylalanyl-L-pipecolyl-L-arginine-p-nitroanilide + H2O
D-phenylalanyl-L-pipecolyl-L-arginine + p-nitroaniline
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?
D-Pro-Phe-Arg-p-nitroanilide + H2O
D-Pro-Phe-Arg + p-nitroaniline
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i.e. S2302, 12% of the activity with N-methylsulfonyl-D-Phe-Gly-Arg-p-nitroanilide, plasma-derived wild-type enzyme
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?
Eph tyrosine kinase receptor EphA2 + H2O
?
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cleavage site at the Arg159-His160 bond
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?
Eph tyrosine kinase receptor EphB2 + H2O
?
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cleavage site at the Arg159-His160 bond
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?
factor IX + H2O
?
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?
factor IX + H2O
activated factor IX + ?
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?
factor IX + H2O
factor IXa + ?
factor VIII + H2O
factor VIIIa + ?
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FVIII activity increases about 4-fold within 30 s in the presence of FVIIa/tissue factor. The heavy chain of FVIII is proteolyzed at Arg336. Arg740 and Arg372
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?
factor X + H2O
?
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?
factor X + H2O
activated factor X
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?
factor X + H2O
activated factor X + ?
Factor X + H2O
Factor Xa + ?
H-D-isoleucyl-L-prolyl-arginine-p-nitroanilide + H2O
H-D-isoleucyl-L-prolyl-arginine + p-nitroaniline
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i.e. S-2288
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?
Ile-Pro-Arg-p-nitroanilide + H2O
?
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?
methanesulfonyl-D-CHA-Gly-Arg-4-amido-4-methylcoumarin + H2O
?
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?
methanesulfonyl-D-cyclohexylalanyl-butyl-arginine p-nitroanilide + H2O
methanesulfonyl-D-cyclohexylalanyl-butyl-arginine + p-nitroaniline
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?
N-acetyl-Ala-P3-P2-Lys-7-amido-4-carbamoylmethylcoumarin + H2O
?
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P2: Val or Thr, P3: Gln, Arg, Asn or Pro
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?
N-methoxycarbonyl-D-Nle-Gly-Arg-p-nitroanilide + H2O
N-methoxycarbonyl-D-Nle-Gly-Arg + p-nitroaniline
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i.e. chromozym X, 11% of the activity with N-methylsulfonyl-D-Phe-Gly-Arg-p-nitroanilide, plasma-derived wild-type enzyme
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?
N-methylsulfonyl-D-Phe-Gly-Arg-4-nitroanilide + H2O
N-methylsulfonyl-D-Phe-Gly-Arg + 4-nitroaniline
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?
N-methylsulfonyl-D-Phe-Gly-Arg-p-nitroanilide + H2O
N-methylsulfonyl-D-Phe-Gly-Arg + p-nitroaniline
N-methylsulfonyl-D-phenyl-D-glycyl-D-arginyl-4-nitroanilide + H2O
N-methylsulfonyl-D-phenyl-D-glycyl-D-arginine + 4-nitroaniline
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?
phosphoinositide + H2O
inositol phosphate + diacylglycerol
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?
protease-activated receptor 2 + H2O
?
pyroGlu-Pro-Arg-p-nitroanilide + H2O
p-nitroaniline + pyroGlu-Pro-Arg
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?
pyroglutamyl-Gly-Arg-p-nitroanilide + H2O
pyroglutamyl-Gly-Arg + p-nitroaniline
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i.e. S2444, 2% of the activity with N-methylsulfonyl-D-Phe-Gly-Arg-p-nitroanilide, plasma-derived wild-type enzyme
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?
pyroglutamyl-Phe-Lys-p-nitroanilide + H2O
pyroglutamyl-D-Phe-Gly-Arg + p-nitroaniline
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i.e. S2403, 1.4% of the activity with N-methylsulfonyl-D-Phe-Gly-Arg-p-nitroanilide, plasma-derived wild-type enzyme
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?
pyroglutamyl-Pro-Arg-p-nitroanilide + H2O
pyroglutamyl-Pro-Arg + p-nitroaniline
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i.e. S2366, 38% of the activity with N-methylsulfonyl-D-Phe-Gly-Arg-p-nitroanilide, plasma-derived wild-type enzyme
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?
S2288 + H2O
D-Ile-Pro-Arg + 4-nitroaniline
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?
signal transducer and activator of transcription 5 + ?
activated signal transducer and activator of transcription 5 + ?
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STAT5
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?
spectrozyme fVIIa + H2O
?
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?
spectrozyme Fxa + H2O
?
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chromogenic substrate
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?
thrombinogen + H2O
thrombin + ?
tissue factor + H2O
?
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?
Trp-Ala-Thr-Arg-7-amido-4-carbamoylmethylcoumarin + H2O
?
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?
Z-D-arginyl-glycyl-arginine-p-nitroanilide + H2O
Z-D-arginyl-glycyl-arginine + p-nitroaniline
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?
additional information
?
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D-Ile-Pro-Arg-4-nitroanilide + H2O
D-Ile-Pro-Arg + 4-nitroaniline
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?
D-Ile-Pro-Arg-4-nitroanilide + H2O
D-Ile-Pro-Arg + 4-nitroaniline
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?
D-Ile-Pro-Arg-4-nitroanilide + H2O
D-Ile-Pro-Arg + 4-nitroaniline
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chromogenic substrate S-2288
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?
D-Ile-Pro-Arg-4-nitroanilide + H2O
D-Ile-Pro-Arg + 4-nitroaniline
S-2288
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?
D-Ile-Pro-Arg-p-nitroanilide + H2O
D-Ile-Pro-Arg + p-nitroaniline
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i.e. S2288
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?
D-Ile-Pro-Arg-p-nitroanilide + H2O
D-Ile-Pro-Arg + p-nitroaniline
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i.e. S2288, 68% of the activity with N-methylsulfonyl-D-Phe-Gly-Arg-p-nitroanilide, plasma-derived wild-type enzyme
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?
D-Phe-pipecolyl-Arg-p-nitroanilide + H2O
D-Phe-pipecolyl-Arg + p-nitroaniline
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?
D-Phe-pipecolyl-Arg-p-nitroanilide + H2O
D-Phe-pipecolyl-Arg + p-nitroaniline
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i.e. S2238, 34% of the activity with N-methylsulfonyl-D-Phe-Gly-Arg-p-nitroanilide, plasma-derived wild-type enzyme
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?
factor IX + H2O
factor IXa + ?
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?
factor IX + H2O
factor IXa + ?
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?
factor IX + H2O
factor IXa + ?
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FVIIa catalyzes activation of factor X
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?
factor X + H2O
activated factor X + ?
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?
factor X + H2O
activated factor X + ?
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i.e. factor Xa
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?
factor X + H2O
activated factor X + ?
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the enzyme initiates blood clotting after interacting with its cofactor tissue factor. The product of the reaction, activated factor X, is also the most efficient activator of zymogen factor VII
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?
factor X + H2O
factor Xa
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667430, 667474, 667584, 667588, 667668, 667680, 668158, 668304, 669415, 669484, 670270, 670935 -
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?
factor X + H2O
factor Xa
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?
factor X + H2O
factor Xa
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?
factor X + H2O
factor Xa
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?
factor X + H2O
factor Xa
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?
Factor X + H2O
Factor Xa + ?
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683347, 683477, 683855, 717385, 731271, 732085, 752660, 752758, 753091, 754519, 755008, 755547, 755589 -
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?
Factor X + H2O
Factor Xa + ?
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?
Factor X + H2O
Factor Xa + ?
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the enzyme is involved in the coagulation cascade, pathways, overview
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?
Factor X + H2O
Factor Xa + ?
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FX cleavage site Asn-Leu-Thr-Ar-/-Ile-Val-Gly-Gly
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?
Factor X + H2O
Factor Xa + ?
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macromolecular substrate interactions at exosites, sites within the FVIIa-TF complex distant from the active site of FVIIa, determine affinity and specificity in the productive recognition of FX
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?
Factor X + H2O
Factor Xa + ?
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FVIIa catalyzes activation of factor X
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?
N-methylsulfonyl-D-Phe-Gly-Arg-p-nitroanilide + H2O
N-methylsulfonyl-D-Phe-Gly-Arg + p-nitroaniline
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?
N-methylsulfonyl-D-Phe-Gly-Arg-p-nitroanilide + H2O
N-methylsulfonyl-D-Phe-Gly-Arg + p-nitroaniline
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i.e. chromozym t-PA
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?
protease-activated receptor 2 + H2O
?
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?
protease-activated receptor 2 + H2O
?
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protease-activated receptor 2 is cleaved by FVIIa in the binary tissue factor-FVIIa complex
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?
thrombinogen + H2O
thrombin + ?
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?
thrombinogen + H2O
thrombin + ?
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antifibrinolytic effect of the enzyme in relation to the activity of thrombin, regulation, overview
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?
additional information
?
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factor VIIa initiates the coagulation pathway upon complex formation with its cellular receptor and cofactor tissue factor
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?
additional information
?
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blood coagulation is initiated when tissue factor binds to coagulation factor VII to give an enzymatically active complex which then activates factors IX and X, leading to thrombin generation and clot formation
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?
additional information
?
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the enzyme plays a key role in the blood coagulation cascade
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?
additional information
?
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the enzyme plays a key role in the blood coagulation cascade
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?
additional information
?
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cell-surface tissue factor TF binds the serine protease factor VIIa to activate coagulation or, alternatively, to trigger signaling through the G protein-coupled, protease-activated receptor 2 relevant to inflammation and angiogenesis, TF-VIIa-mediated coagulation and cell signaling involve distinct cellular pools of TF, regulation, overview
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?
additional information
?
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membrane binding constitutes a key process in enzymatic activation of various blood coagulation factors
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?
additional information
?
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a loop of factor VIIa influences the macromolecular substrate specificity, overview
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?
additional information
?
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structure-function relationship, the enzyme forms a complex with the cell surface receptor tissue factor TF required for attaining its catalytically competent conformation, Asp338 is a catalytically important residue
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?
additional information
?
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substrate and cleavage site specificity with 7-amino-4-carbamoylmethylcoumarin-linked tetrapeptides, specificity profiling of the recombinant enzyme, overview
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?
additional information
?
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complex formation with the essential protein cofactor tissue factor
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?
additional information
?
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factor VII interacts with tissue factor
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?
additional information
?
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enzyme blood coagulation activity is regulated in the circadian clock machinery, overview
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?