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Literature summary for 3.4.21.21 extracted from

  • Gajsiewicz, J.M.; Morrissey, J.H.
    Structure-function relationship of the interaction between tissue factor and factor VIIa (2015), Semin. Thromb. Hemost., 41, 682-690 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.21

Activating Compound

Activating Compound Comment Organism Structure
tissue factor tissue factor allosterically activates factor VIIa by several mechanisms such as active site positioning, spatial stabilization, and direct interactions with the substrate Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the enzyme binds the phospholipid membrane in a Ca2+-dependent manner. Ca2+ ions are required for assembly and function of the tissue factor-enzyme complex Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Factor X + H2O Homo sapiens
-
 Factor Xa + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Factor X + H2O
-
 Homo sapiens Factor Xa + ?
-
 ?

Subunits

Subunits Comment Organism
? x * 46000, calculated from amino acid sequence Homo sapiens

Synonyms

Synonyms Comment Organism
factor VIIa
-
 Homo sapiens
FVIIa
-
 Homo sapiens