3.4.21.117: stratum corneum chymotryptic enzyme

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For detailed information about stratum corneum chymotryptic enzyme, go to the full flat file.

Reaction

cleavage of proteins with aromatic side chains in the P1 position =

Synonyms

hK7, HSCCE, human stratum corneum chymotryptic enzyme, K7, kallikrein 7, kallikrein-7, kallikrein-related peptidase, kallikrein-related peptidase 7, KLK7, More, S01.300, SCCE, stratum corneum chymotryptic enzyme, tissue kallikrein, tissue kallikrein 7

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.117 stratum corneum chymotryptic enzyme

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Results	in table
6	Activating Compound
2	AA Sequence
16	Application
2	CAS Registry Number
25	Cloned(Commentary)
7	Crystallization (Commentary)
286	Disease/ Diagnostics
2	Expression
14	General Information
17	IC50 Value
100	Inhibitors
27	kcat/KM [mM/s]
30	Ki Value [mM]
38	KM Value [mM]
6	Localization
7	Metals/Ions
4	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
69	Organism
41	PDB ID
15	pH Optimum
1	pH Range
9	Posttranslational Modification
9	Protein Variants
10	Purification (Commentary)
11	Reaction
1	Reaction Type
68	Reference
1	Renatured (Commentary)
174	Source Tissue
4	Specific Activity [micromol/min/mg]
183	Substrates and Products (Substrate)
7	Subunits
103	Synonyms
13	Temperature Optimum [°C]
36	Turnover Number [1/s]

Expression

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Expression on EC 3.4.21.117 - stratum corneum chymotryptic enzyme

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

increased extracellular calcium-induced KLK7 mRNA expression and protein release in epidermal keratinocyte. Increased protease activity and differential processing of cathelicidin accompanies increased KLK expression. 1,25(OH)2VD3 increases KLK expression independently of differentiation in keratinocytes

Homo sapiens

-

709408

KLK7 expression is decreased in prostate cancer cells compared to normal benign prostate cells

Homo sapiens

-

718165