3.4.21.117: stratum corneum chymotryptic enzyme

This is an abbreviated version!
For detailed information about stratum corneum chymotryptic enzyme, go to the full flat file.

Word Map on EC 3.4.21.117

3.4.21.117

klk7

desquamation

keratinocytes

cornified

corneocyte

netherton

corneodesmosomes

desmogleins

corneodesmosin

spink5

medicine

desmocollin

vaspin

diagnostics

molecular biology

desquamatory

Reaction

cleavage of proteins with aromatic side chains in the P1 position =

Synonyms

hK7, HSCCE, human stratum corneum chymotryptic enzyme, K7, kallikrein 7, kallikrein-7, kallikrein-related peptidase, kallikrein-related peptidase 7, KLK7, More, S01.300, SCCE, stratum corneum chymotryptic enzyme, tissue kallikrein, tissue kallikrein 7

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.117 stratum corneum chymotryptic enzyme

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Results	in table
6	Activating Compound
2	AA Sequence
16	Application
2	CAS Registry Number
25	Cloned(Commentary)
7	Crystallization (Commentary)
286	Disease/ Diagnostics
2	Expression
14	General Information
17	IC50 Value
100	Inhibitors
27	kcat/KM [mM/s]
30	Ki Value [mM]
38	KM Value [mM]
6	Localization
7	Metals/Ions
4	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
69	Organism
41	PDB ID
15	pH Optimum
1	pH Range
9	Posttranslational Modification
9	Protein Variants
10	Purification (Commentary)
11	Reaction
1	Reaction Type
68	Reference
1	Renatured (Commentary)
174	Source Tissue
4	Specific Activity [micromol/min/mg]
183	Substrates and Products (Substrate)
7	Subunits
103	Synonyms
13	Temperature Optimum [°C]
36	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.21.117 - stratum corneum chymotryptic enzyme

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0.0959

(4R)-4-benzyl-2-(2-methylphenyl)-3,4-dihydro-5H-pyrido[10,20:1,2]imidazo[4,5-d][1,3]diazepin-5-one

Homo sapiens

pH 8..0, 37°C

731754

0.0839

(4S)-4-benzyl-2-(2,4-dimethylphenyl)-3,4-dihydro-5Hpyrido[10,20:1,2]imidazo [4,5-d][1,3]diazepin-5-one

Homo sapiens

pH 8..0, 37°C

731754

0.0809

(4S)-4-benzyl-2-(2,5-dimethoxyphenyl)-3,4-dihydro-5Hpyrido[10,20:1,2]imidazo [4,5-d][1,3]diazepin-5-one

Homo sapiens

pH 8..0, 37°C

731754

0.057

(4S)-4-benzyl-2-(2-methylphenyl)-3,4-dihydro-5H-pyrido[1',2':1,2]imidazo[4,5-d][1,3]diazepin-5-one

Homo sapiens

pH 8..0, 37°C

731754

0.0557

(4S)-4-benzyl-2-(3,4,5-trimethoxyphenyl)-3,4-dihydro-5Hpyrido[10,20:1,2] imidazo[4,5-d][1,3]diazepin-5-one

Homo sapiens

pH 8..0, 37°C

731754

0.0335

(4S)-4-benzyl-2-(3,4-dimethoxyphenyl)-3,4-dihydro-5Hpyrido[10,20:1,2]imidazo [4,5-d][1,3]diazepin-5-one

Homo sapiens

pH 8..0, 37°C

731754

0.1248

(4S)-4-benzyl-2-(3-hydroxyphenyl)-3,4-dihydro-5H-pyrido[10,20:1,2]imidazo-[4,5-d][1,3]diazepin-5-one

Homo sapiens

pH 8..0, 37°C

731754

0.072

(4S)-4-benzyl-2-(4-methoxyphenyl)-3,4-dihydro-5H-pyrido[1',2':1,2]imidazo[4,5-d][1,3]diazepin-5-one

Homo sapiens

pH 8..0, 37°C

731754

0.068

(4S)-4-benzyl-2-(4-methylphenyl)-3,4-dihydro-5H-pyrido[1',2':1,2]imidazo[4,5-d][1,3]diazepin-5-one

Homo sapiens

pH 8..0, 37°C

731754

0.1354

(S)-N-(1-(2-amino-imidazo[1,2-a]pyridin-3-yl)-1-oxo-3-phenylpropan-2-yl)-2-methylbenzamide

Homo sapiens

pH 8..0, 37°C

731754

0.1492

(S)-N-(1-(2-amino-imidazo[1,2-a]pyridin-3-yl)-1-oxo-3-phenylpropan-2-yl)-2-phenylacetamide

Homo sapiens

pH 8..0, 37°C

731754

0.00039 - 0.0004

1-(2-bromobenzene-1-sulfonyl)-5-methyl-3-(2-methyl-4,5-dihydro-1H-imidazol-4-yl)-1H-indole

2 entries

0.0012 - 0.0015

1-(2-chlorobenzene-1-sulfonyl)-5-methyl-3-(2-methyl-4,5-dihydro-1H-imidazol-4-yl)-1H-indole

2 entries

0.00007

2-(2-fluoro-phenyl)-5,6,7,8-tertrahydro-benzol[4,5]thieno[2,3-d][1,3]oxazin-4-one

Homo sapiens

P49862

699037

0.026

LEKTI domain 6

Homo sapiens

P49862

683785