3.4.21.117: stratum corneum chymotryptic enzyme
This is an abbreviated version!
For detailed information about stratum corneum chymotryptic enzyme, go to the full flat file.
Word Map on EC 3.4.21.117
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3.4.21.117
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klk7
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desquamation
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keratinocytes
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cornified
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corneocyte
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netherton
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corneodesmosomes
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desmogleins
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corneodesmosin
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spink5
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medicine
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desmocollin
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vaspin
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diagnostics
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molecular biology
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desquamatory
- 3.4.21.117
- klk7
-
desquamation
- keratinocytes
-
cornified
- corneocyte
- netherton
-
corneodesmosomes
-
desmogleins
- corneodesmosin
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spink5
- medicine
-
desmocollin
- vaspin
- diagnostics
- molecular biology
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desquamatory
Reaction
cleavage of proteins with aromatic side chains in the P1 position =
Synonyms
hK7, HSCCE, human stratum corneum chymotryptic enzyme, K7, kallikrein 7, kallikrein-7, kallikrein-related peptidase, kallikrein-related peptidase 7, KLK7, More, S01.300, SCCE, stratum corneum chymotryptic enzyme, tissue kallikrein, tissue kallikrein 7
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Reference on EC 3.4.21.117 - stratum corneum chymotryptic enzyme
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (P49862)
El Moujahed, A.; Gutman, N.; Brillard, M.; Gauthier, F.
Substrate specificity of two kallikrein family gene products isolated from the rat submandibular gland
FEBS Lett.
265
137-140
1990
Rattus norvegicus
Yousef, G.M.; Diamandis, E.P.
The new human tissue kallikrein gene family: structure, function, and association to disease
Endocr. Rev.
22
184-204
2001
Homo sapiens (P49862)
Lundstrom, A.; Egelrud, T.
Stratum corneum chymotryptic enzyme: a proteinase which may be generally present in the stratum corneum and with a possible involvement in desquamation
Acta Derm. Venereol.
71
471-474
1991
Homo sapiens
Egelrud, T.
Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation
J. Invest. Dermatol.
101
200-204
1993
Homo sapiens
Hansson, L.; Stromqvist, M.; Backman, A.; Wallbrandt, P.; Carlstein, A.; Egelrud, T.
Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase
J. Biol. Chem.
269
19420-19426
1994
Homo sapiens (P49862), Homo sapiens
Skytt, A.; Stromqvist, M.; Egelrud, T.
Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme
Biochem. Biophys. Res. Commun.
211
586-589
1995
Homo sapiens
Franzke, C.W.; Baici, A.; Bartels, J.; Christophers, E.; Wiedow, O.
Antileukoprotease inhibits stratum corneum chymotryptic enzyme. Evidence for a regulative function in desquamation
J. Biol. Chem.
271
21886-21890
1996
Homo sapiens
Tanimoto, H.; Underwood, L.J.; Shigemasa, K.; Yan Yan, M.S.; Clarke, J.; Parmley, T.H.; O'Brien, T.J.
The stratum corneum chymotryptic enzyme that mediates shedding and desquamation of skin cells is highly overexpressed in ovarian tumor cells
Cancer
86
2074-2082
1999
Homo sapiens
Nylander-Lundqvist, E.; Egelrud, T.
Formation of active IL-1 beta from pro-IL-1 beta catalyzed by stratum corneum chymotryptic enzyme in vitro
Acta Derm. Venereol.
77
203-206
1997
Homo sapiens
Yousef, G.M.; Scorilas, A.; Magklara, A.; Soosaipillai, A.; Diamandis, E.P.
The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation
Gene
254
119-128
2000
Homo sapiens (P49862), Homo sapiens
Ny, A.; Egelrud, T.
Epidermal hyperproliferation and decreased skin barrier function in mice overexpressing stratum corneum chymotryptic enzyme
Acta Derm. Venereol.
84
18-22
2004
Homo sapiens
Planque, C.; de Monte, M.; Guyetant, S.; Rollin, J.; Desmazes, C.; Panel, V.; Lemarie, E.; Courty, Y.
KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer
Biochem. Biophys. Res. Commun.
329
1260-1266
2005
Homo sapiens
Tan, O.L.; Whitbread, A.K.; Clements, J.A.; Dong, Y.
Kallikrein-related peptidase (KLK) family mRNA variants and protein isoforms in hormone-related cancers: do they have a function?
Biol. Chem.
387
697-705
2006
Homo sapiens
Prezas, P.; Arlt, M.J.; Viktorov, P.; Soosaipillai, A.; Holzscheiter, L.; Schmitt, M.; Talieri, M.; Diamandis, E.P.; Krueger, A.; Magdolen, V.
Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells
Biol. Chem.
387
807-811
2006
Homo sapiens
Diamandis, E.P.; Scorilas, A.; Kishi, T.; Blennow, K.; Luo, L.Y.; Soosaipillai, A.; Rademaker, A.W.; Sjogren, M.
Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimers disease and frontotemporal dementia
Clin. Biochem.
37
230-237
2004
Homo sapiens
Kishi, T.; Soosaipillai, A.; Grass, L.; Little, S.P.; Johnstone, E.M.; Diamandis, E.P.
Development of an immunofluorometric assay and quantification of human kallikrein 7 in tissue extracts and biological fluids
Clin. Chem.
50
709-716
2004
Homo sapiens (P49862), Homo sapiens
Baretton, G.; Luther, T.; Tjan-Heijnen, V.C.; Talieri, M.; Schmitt, M.; Sweep, F.C.; Span, P.N.; Magdolen, V.
Quantitative reverse transcription-PCR assay for detection of mRNA encoding full-length human tissue kallikrein 7: prognostic relevance of KLK7 mRNA expression in breast cancer
Clin. Chem.
52
1070-1079
2006
Homo sapiens (P49862), Homo sapiens
Santin, A.D.; Cane, S.; Bellone, S.; Bignotti, E.; Palmieri, M.; De Las Casas, L.E.; Roman, J.J.; Anfossi, S.; OBrien, T.; Pecorelli, S.
The serine protease stratum corneum chymotryptic enzyme (kallikrein 7) is highly overexpressed in squamous cervical cancer cells
Gynecol. Oncol.
94
283-288
2004
Homo sapiens
Caubet, C.; Jonca, N.; Brattsand, M.; Guerrin, M.; Bernard, D.; Schmidt, R.; Egelrud, T.; Simon, M.; Serre, G.
Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7
J. Invest. Dermatol.
122
1235-1244
2004
Homo sapiens (P49862)
Vasilopoulos, Y.; Cork, M.J.; Murphy, R.; Williams, H.C.; Robinson, D.A.; Duff, G.W.; Ward, S.J.; Tazi-Ahnini, R.
Genetic association between an AACC insertion in the 3UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis
J. Invest. Dermatol.
123
62-66
2004
Homo sapiens (P49862), Homo sapiens
Tian, X.; Shigemasa, K.; Hirata, E.; Gu, L.; Uebaba, Y.; Nagai, N.; OBrien, T.J.; Ohama, K.
Expression of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in uterine endocervical glands and in cervical adenocarcinomas
Oncol. Rep.
12
1001-1006
2004
Homo sapiens
Talieri, M.; Diamandis, E.P.; Gourgiotis, D.; Mathioudaki, K.; Scorilas, A.
Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: A new potential biomarker for prognosis of breast carcinoma
Thromb. Haemost.
91
180-186
2004
Homo sapiens
Psyrri, A.; Kountourakis, P.; Scorilas, A.; Markakis, S.; Camp, R.; Kowalski, D.; Diamandis, E.P.; Dimopoulos, M.A.
Human tissue kallikrein 7, a novel biomarker for advanced ovarian carcinoma using a novel in situ quantitative method of protein expression
Ann. Oncol.
19
1271-1277
2008
Homo sapiens
Prezas, P.; Scorilas, A.; Yfanti, C.; Viktorov, P.; Agnanti, N.; Diamandis, E.; Talieri, M.
The role of human tissue kallikreins 7 and 8 in intracranial malignancies
Biol. Chem.
387
1607-1612
2006
Homo sapiens
Singh, J.; Naran, A.; Misso, N.L.; Rigby, P.J.; Thompson, P.J.; Bhoola, K.D.
Expression of kallikrein-related peptidases (KRP/hK5, 7, 6, 8) in subtypes of human lung carcinoma
Int. Immunopharmacol.
8
300-306
2008
Homo sapiens
Debela, M.; Magdolen, V.; Schechter, N.; Valachova, M.; Lottspeich, F.; Craik, C.S.; Choe, Y.; Bode, W.; Goettig, P.
Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences
J. Biol. Chem.
281
25678-25688
2006
Homo sapiens (P49862)
Deraison, C.; Bonnart, C.; Lopez, F.; Besson, C.; Robinson, R.; Jayakumar, A.; Wagberg, F.; Brattsand, M.; Hachem, J.P.; Leonardsson, G.; Hovnanian, A.
LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction
Mol. Biol. Cell
18
3607-3619
2007
Homo sapiens
Debela, M.; Hess, P.; Magdolen, V.; Schechter, N.M.; Steiner, T.; Huber, R.; Bode, W.; Goettig, P.
Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7
Proc. Natl. Acad. Sci. USA
104
16086-16091
2007
Homo sapiens (P49862), Homo sapiens
Fernandez, I.S.; Staendker, L.; Forssmann, W.G.; Gimenez-Gallego, G.; Romero, A.
Crystallization and preliminary crystallographic studies of human kallikrein 7, a serine protease of the multigene kallikrein family
Acta Crystallogr. Sect. F
F63
669-672
2007
Homo sapiens
Stenshamn, K.; Bongcam-Rudloff, E.; Hillbertz, N.S.; Nodtvedt, A.; Bergvall, K.; Hedhammar, A.; Andersson, G.
Evaluation of kallikrein 7 as a disease-causing gene for canine atopic dermatitis using microsatellite-based association mapping
Anim. Genet.
37
601-603
2006
Canis lupus familiaris
Ramani, V.C.; Haun, R.S.
The extracellular matrix protein fibronectin is a substrate for kallikrein 7
Biochem. Biophys. Res. Commun.
369
1169-1173
2008
Homo sapiens
Johnson, S.K.; Ramani, V.C.; Hennings, L.; Haun, R.S.
Kallikrein 7 enhances pancreatic cancer cell invasion by shedding E-cadherin
Cancer
109
1811-1820
2007
Homo sapiens
Shan, S.J.; Scorilas, A.; Katsaros, D.; Rigault de la Longrais, I.; Massobrio, M.; Diamandis, E.P.
Unfavorable prognostic value of human kallikrein 7 quantified by ELISA in ovarian cancer cytosols
Clin. Chem.
52
1879-1886
2006
Homo sapiens
Fernandez, I.S.; Staendker, L.; Maegert, H.J.; Forssmann, W.G.; Gimenez-Gallego, G.; Romero, A.
Crystal structure of human epidermal kallikrein 7 (hK7) synthesized directly in its native state in E. coli: insights into the atomic basis of its inhibition by LEKTI domain 6 (LD6)
J. Mol. Biol.
377
1488-1497
2008
Homo sapiens (P49862), Homo sapiens
Debela, M.; Beaufort, N.; Magdolen, V.; Schechter, N.M.; Craik, C.S.; Schmitt, M.; Bode, W.; Goettig, P.
Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7
Biol. Chem.
389
623-632
2008
Homo sapiens
Pettus, J.R.; Johnson, J.J.; Shi, Z.; Davis, J.W.; Koblinski, J.; Ghosh, S.; Liu, Y.; Ravosa, M.J.; Frazier, S.; Stack, M.S.
Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity
Histol. Histopathol.
24
197-207
2009
Homo sapiens, Mus musculus
Buraczewska, I.; Berne, B.; Lindberg, M.; Loden, M.; Toermae, H.
Long-term treatment with moisturizers affects the mRNA levels of genes involved in keratinocyte differentiation and desquamation
Arch. Dermatol. Res.
301
175-181
2009
Homo sapiens
Xuan, Q.; Yang, X.; Mo, L.; Huang, F.; Pang, Y.; Qin, M.; Chen, Z.; He, M.; Wang, Q.; Mo, Z.N.
Expression of the serine protease kallikrein 7 and its inhibitor antileukoprotease is decreased in prostate cancer
Arch. Pathol. Lab. Med.
132
1796-1801
2008
Homo sapiens
Eissa, A.; Diamandis, E.P.
Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions
Biol. Chem.
389
669-680
2008
Homo sapiens
Dong, Y.; Matigian, N.; Harvey, T.J.; Samaratunga, H.; Hooper, J.D.; Clements, J.A.
Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function
Biol. Chem.
389
99-109
2008
Homo sapiens
Ramani, V.C.; Hennings, L.; Haun, R.S.
Desmoglein 2 is a substrate of kallikrein 7 in pancreatic cancer
BMC Cancer
8
373
2008
Homo sapiens
Termini, L.; Boccardo, E.; Esteves, G.H.; Hirata, R.; Martins, W.K.; Colo, A.E.; Neves, E.J.; Villa, L.L.; Reis, L.F.
Characterization of global transcription profile of normal and HPV-immortalized keratinocytes and their response to TNF treatment
BMC Med. Genomics
1
29
2008
Homo sapiens
Weidinger, S.; Baurecht, H.; Wagenpfeil, S.; Henderson, J.; Novak, N.; Sandilands, A.; Chen, H.; Rodriguez, E.; ORegan, G.M.; Watson, R.; Liao, H.; Zhao, Y.; Barker, J.N.; Allen, M.; Reynolds, N.; Meggitt, S.; Northstone, K.; Smith, G.D.; Strobl, C.; Stahl, C.; Kneib, T.; Klopp, N.; Bieber, T.; Behren, B.e.h.r.e.n.d.
Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk
J. Allergy Clin. Immunol.
122
560-568
2008
Homo sapiens
Doering, K.; Meder, G.; Hinnenberger, M.; Woelcke, J.; Mayr, L.M.; Hassiepen, U.
A fluorescence lifetime-based assay for protease inhibitor profiling on human kallikrein 7
J. Biomol. Screen.
14
1-9
2009
Homo sapiens (P49862), Homo sapiens
Ramani, V.C.; Haun, R.S.
Expression of kallikrein 7 diminishes pancreatic cancer cell adhesion to vitronectin and enhances urokinase-type plasminogen activator receptor shedding
Pancreas
37
399-404
2008
Homo sapiens
Gabril, M.; White, N.M.; Moussa, M.; Chow, T.F.; Metias, S.M.; Fatoohi, E.; Yousef, G.M.
Immunohistochemical analysis of kallikrein-related peptidases in the normal kidney and renal tumors: potential clinical implications
Biol. Chem.
391
403-409
2010
Homo sapiens
Ohler, A.; Debela, M.; Wagner, S.; Magdolen, V.; Becker-Pauly, C.
Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation
Biol. Chem.
391
455-460
2010
Homo sapiens
Dong, Y.; Tan, O.L.; Loessner, D.; Stephens, C.; Walpole, C.; Boyle, G.M.; Parsons, P.G.; Clements, J.A.
Kallikrein-related peptidase 7 promotes multicellular aggregation via the alpha(5)beta(1) integrin pathway and paclitaxel chemoresistance in serous epithelial ovarian carcinoma
Cancer Res.
70
2624-2633
2010
Homo sapiens
Li, X.; Liu, J.; Wang, Y.; Zhang, L.; Ning, L.; Feng, Y.
Parallel underexpression of kallikrein 5 and kallikrein 7 mRNA in breast malignancies
Cancer Sci.
100
601-607
2009
Homo sapiens
Termini, L.; Maciag, P.C.; Soares, F.A.; Nonogaki, S.; Pereira, S.M.; Alves, V.A.; Longatto-Filho, A.; Villa, L.L.
Analysis of human kallikrein 7 expression as a potential biomarker in cervical neoplasia
Int. J. Cancer
127
485-490
2010
Homo sapiens
Morizane, S.; Yamasaki, K.; Kabigting, F.D.; Gallo, R.L.
Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D3, and retinoic acid
J. Invest. Dermatol.
130
1297-1306
2010
Homo sapiens
Talieri, M.; Mathioudaki, K.; Prezas, P.; Alexopoulou, D.K.; Diamandis, E.P.; Xynopoulos, D.; Ardavanis, A.; Arnogiannaki, N.; Scorilas, A.
Clinical significance of kallikrein-related peptidase 7 (KLK7) in colorectal cancer
Thromb. Haemost.
101
741-747
2009
Homo sapiens
Ramani, V.C.; Kaushal, G.P.; Haun, R.S.
Proteolytic action of kallikrein-related peptidase 7 produces unique active matrix metalloproteinase-9 lacking the C-terminal hemopexin domains
Biochim. Biophys. Acta
1813
1525-1531
2011
Homo sapiens
Jamaspishvili, T.; Scorilas, A.; Kral, M.; Khomeriki, I.; Kurfurstova, D.; Kolar, Z.; Bouchal, J.
Immunohistochemical localization and analysis of kallikrein-related peptidase 7 and 11 expression in paired cancer and benign foci in prostate cancer patients
Neoplasma
58
298-303
2011
Homo sapiens
Oliveira, J.R.; Bertolin, T.C.; Andrade, D.; Oliveira, L.C.; Kondo, M.Y.; Santos, J.A.; Blaber, M.; Juliano, L.; Severino, B.; Caliendo, G.; Santagada, V.; Juliano, M.A.
Specificity studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity
Biochim. Biophys. Acta
1854
73-83
2015
Homo sapiens (P49862), Homo sapiens
Walker, F.; Nicole, P.; Jallane, A.; Soosaipillai, A.; Mosbach, V.; Oikonomopoulou, K.; Diamandis, E.P.; Magdolen, V.; Darmoul, D.
Kallikrein-related peptidase 7 (KLK7) is a proliferative factor that is aberrantly expressed in human colon cancer
Biol. Chem.
395
1075-1086
2014
Homo sapiens
Shropshire, T.D.; Reifert, J.; Rajagopalan, S.; Baker, D.; Feinstein, S.C.; Daugherty, P.S.
Amyloid ? peptide cleavage by kallikrein 7 attenuates fibril growth and rescues neurons from Abeta-mediated toxicity in vitro
Biol. Chem.
395
109-118
2014
Rattus norvegicus
Arama, D.; Soualmia, F.; Lisowski, V.; Longevial, J.; Bosc, E.; Maillard, L.; Martinez, J.; Masurier, N.; El Amri, C.
Pyrido-imidazodiazepinones as a new class of reversible inhibitors of human kallikrein 7
Eur. J. Med. Chem.
93
203-213
2015
Homo sapiens
-
Li, W.; Zhao, Y.; Ren, L.; Wu, X.
Serum human kallikrein 7 represents a new marker for cervical cancer
Med. Oncol.
31
208
2014
Homo sapiens
Zhang, C.; Zhu, Y.; Rui, W.; Dai, J.; Shen, Z.
Expression of kallikrein-related peptidase 7 is decreased in prostate cancer
Asian J. Androl.
17
106-110
2015
Homo sapiens (P49862), Homo sapiens
Haddada, M.; Draoui, H.; Deschamps, L.; Walker, F.; Delaunay, T.; Brattsand, M.; Magdolen, V.; Darmoul, D.
Kallikrein-related peptidase 7 overexpression in melanoma cells modulates cell adhesion leading to a malignant phenotype
Biol. Chem.
399
1099-1105
2018
Homo sapiens (P49862), Homo sapiens
Murafuji, H.; Muto, T.; Goto, M.; Imajo, S.; Sugawara, H.; Oyama, Y.; Minamitsuji, Y.; Miyazaki, S.; Murai, K.; Fujioka, H.
Discovery and structure-activity relationship of imidazolinylindole derivatives as kallikrein 7 inhibitors
Bioorg. Med. Chem. Lett.
29
334-338
2019
Homo sapiens (P49862), Homo sapiens, Mus musculus (Q91VE3), Mus musculus
Yu, Y.; Prassas, I.; Dimitromanolakis, A.; Diamandis, E.P.
Novel biological substrates of human kallikrein 7 identified through degradomics
J. Biol. Chem.
290
17762-17775
2015
Homo sapiens (P49862), Homo sapiens
de Veer, S.J.; Furio, L.; Swedberg, J.E.; Munro, C.A.; Brattsand, M.; Clements, J.A.; Hovnanian, A.; Harris, J.M.
Selective substrates and inhibitors for kallikrein-related peptidase 7 (KLK7) shed light on KLK proteolytic activity in the stratum corneum
J. Invest. Dermatol.
137
430-439
2017
Homo sapiens (P49862)
Silva, L.M.; Stoll, T.; Kryza, T.; Stephens, C.R.; Hastie, M.L.; Irving-Rodgers, H.F.; Dong, Y.; Gorman, J.J.; Clements, J.A.
Mass spectrometry-based determination of kallikrein-related peptidase 7 (KLK7) cleavage preferences and subsite dependency
Sci. Rep.
7
6789
2017
Homo sapiens (P49862), Homo sapiens
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