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3.4.21.117: stratum corneum chymotryptic enzyme

This is an abbreviated version!
For detailed information about stratum corneum chymotryptic enzyme, go to the full flat file.

Word Map on EC 3.4.21.117

Reaction

cleavage of proteins with aromatic side chains in the P1 position =

Synonyms

hK7, HSCCE, human stratum corneum chymotryptic enzyme, K7, kallikrein 7, kallikrein-7, kallikrein-related peptidase, kallikrein-related peptidase 7, KLK7, More, S01.300, SCCE, stratum corneum chymotryptic enzyme, tissue kallikrein, tissue kallikrein 7

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.117 stratum corneum chymotryptic enzyme

KM Value

KM Value on EC 3.4.21.117 - stratum corneum chymotryptic enzyme

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0009
Abz-AIKFFSA-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0043
Abz-ALFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0032
Abz-FLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.002
Abz-GFSPFRSSRI-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.069
Abz-GFSPFRSSRIGEIKEETT-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0062
Abz-GLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0034
Abz-HLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0027
Abz-ILFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0035
Abz-KAFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.003
Abz-KFFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0018
Abz-KLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0034
Abz-KLYSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0025
Abz-KPFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0019
Abz-KVFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0027
Abz-KYFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0046
Abz-LLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0004
Abz-MISLMKRP-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0017
Abz-NLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0052
Abz-QLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0041
Abz-RLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0021
Abz-VLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine
pH 7.5, 37°C
0.0059
Ac-ED(5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid)KPILFRLGK(4-(4-dimethylaminophenylazo)benzoic acid)E-NH2
kcat/KM: 170000/Msec
0.048
Ac-EFKPILWRLGC-(6-(9-oxo-9H-acridin-10-yl)-hexanoate)E-NH2
Vmax: 12 nM/sec
0.08
acetyl-Phe-Val-Arg-4-nitroanilide
-
pH 8.0, 37°C
0.048
KHLF-4-nitroanilide
pH 8.0, 23°C
0.044
KHLY-4-nitroanilide
pH 8.0, 23°C
0.0443
L-Phe-7-amido-4-methylcoumarin
in 50 mM HEPES, pH 7.5, 150 mM NaCl, 0.005% Tween 20, at 25°C
0.0402
L-Tyr-7-amido-4-methylcoumarin
in 50 mM HEPES, pH 7.5, 150 mM NaCl, 0.005% Tween 20, at 25°C
0.0159
Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2
-
0.65
methoxy-succinyl-Arg-Pro-Tyr-4-nitroanilide
0.304 - 0.43
methoxy-succinyl-Arg-Pro-Tyr-7-amido-4-methylcoumarin
0.0402 - 0.0443
Phe-7-amido-4-methylcoumarin
0.049
QHLY-4-nitroanilide
pH 8.0, 23°C
0.22
succinyl-Phe-Leu-Phe-4-nitroanilide
-
pH 8.0, 37°C
additional information
additional information
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