3.4.21.117: stratum corneum chymotryptic enzyme
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For detailed information about stratum corneum chymotryptic enzyme, go to the full flat file.
Word Map on EC 3.4.21.117
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3.4.21.117
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klk7
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desquamation
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keratinocytes
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cornified
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corneocyte
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netherton
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corneodesmosomes
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desmogleins
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corneodesmosin
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spink5
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medicine
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desmocollin
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vaspin
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diagnostics
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molecular biology
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desquamatory
- 3.4.21.117
- klk7
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desquamation
- keratinocytes
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cornified
- corneocyte
- netherton
-
corneodesmosomes
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desmogleins
- corneodesmosin
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spink5
- medicine
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desmocollin
- vaspin
- diagnostics
- molecular biology
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desquamatory
Reaction
cleavage of proteins with aromatic side chains in the P1 position =
Synonyms
hK7, HSCCE, human stratum corneum chymotryptic enzyme, K7, kallikrein 7, kallikrein-7, kallikrein-related peptidase, kallikrein-related peptidase 7, KLK7, More, S01.300, SCCE, stratum corneum chymotryptic enzyme, tissue kallikrein, tissue kallikrein 7
ECTree
3.4.21.117 stratum corneum chymotryptic enzymeAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.4.21.117 - stratum corneum chymotryptic enzyme
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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breast cancer patients with KLK7 positive tumors have relatively shorter disease-free survival and overall survival than patients with KLK7 negative tumors
breast carcinoma cell line, enzyme is upregulated by estrogens and slightly by glucocorticoids
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increased expression of kallikrein 7 and decreased expression of its inhibitor antileukoprotease might play an important role in cervical adenocarcinoma development
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50% of the primary and 50% of the established cervical cancer cell lines express kallikrein 7
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cervical intraepithelial neoplasia, cervicitis, squamous cervical carcinomas, and cervical adenocarcinomas
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semi-quantitative RT-PCR determination and immunohistochemical analysis
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the transcriptional changes 3 and 60 h after TNF treatment of normal, human papillomaviruses 16- and human papillomaviruses 18-immortalized keratinocytes is analyzed by microarray analysis. KLK7 shows a differential expression pattern associated with the differential response to TNF. KLK7 expression pattern is is equally expressed in TNF-treated or untreated human papillomaviruses 18-immortalized cells but it is not detected in normal primary keratinocytes or human papillomaviruses 16-immortalized cells
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KLK7 shows strong expression in low grade in contrast to high grade clear cell renal cell carcinoma, RCC, overview. The expression of KLK7 can distinguish between oncocytoma and chromophobe RCC
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KLK7 is strongly expressed in the tissue of patients with squamous cell carcinoma and differentiated tumors
additional information
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in contrast to the expression in ovarian cancer, high expression of KLK 7 is strongly associated with good prognosis in breast cancer patients
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decrease in level of kallikrein 7 in patients with Alzheimer's disease and patients with frontotemporal dementia
the enzyme is strongly expressed in the upper layers of the epidermis
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KLK7, KLK5, and cathelicidin colocalizes in keratinocytes lamellar granules stimulated with 1,25(OH)2VD3
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KLK7 expression in the normal kidney shows granular cytoplasmic expression in tubules (stronger intensity in distal than proximal) and no expression in the mesangium
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highest concentrations of KLK7 mRNA are found in the non-cancerous tissue of patients with (well or moderately) differentiated tumors and the lowest in those with poorly differentiated tumors
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in the oral cavity, strong reactivity for KLK7 in human oral squamous cell carcinoma tissues, immunohistochemical analysis, overview
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in the oral cavity, strong reactivity for KLK7 in orthotopic murine tumors, immunohistochemical analysis, overview
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a short mRNA variant for KLK7 (alternative AUG, predicted protein N-terminally truncated and lacking catalytic histidine residue) expressed in normal ovary and in ovarian cancer
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overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells
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short mRNA variant for KLK7 (alternative AUG, predicted protein N-terminally truncated and lacking catalytic histidine residue) expressed in normal ovary and in ovarian cancer
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quantitative in situ protein expression analysis of 150 advanced-stage ovarian cancer samples of primary epithelial ovarian cancer patients, method development, overview
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over-expressed in ovarian carcinoma tissues. Elevated KLK 7 mRNA expression in tumor tissue is associated with poorer prognosis for ovarian cancer patients
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KLK7 is upregulated in epithelial ovarian carcinoma, expression of two different KLK7 transcripts, KLK7-253 and KLK7-181, simultaneously
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KLK7 and KLK5 are expressed in pancreatic tissues by acinar cells. Motifs in the promoter of KLK7 and KLK 5 are identified for transcription factors which confer pancreatic expression
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kallikrein 7 is overexpressed in pancreatic adenocarcinomas as well as other human cancers
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PCR expression profile of serine proteases from both healthy and malignant pancreatic tissues
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ALP is significantly decreased in prostate cancers compared with that in benign prostate epithelial cells. Immunohistochemical expression of kallikrein 7 is observed in prostate epithelial cells, whereas little or no staining is observed in prostate cancer. Western blot analysis reveals that hK7 and antileukoprotease are decreased in malignant prostate epithelium
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significantly increased serum enzyme levels in cervical cancer patients compared to healthy individuals and patients with benign cervical disease
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in a randomized controlled study on 20 volunteers, epidermal mRNA expression of genes essential for keratinocyte differentiation and desquamation after a 7-week treatment with two moisturizers is analyzed. Treatment with one test moisturizer (hydrocarbon cream) increased gene expression of involucrin, transglutaminase 1, kallikrein 5, and kallikrein 7, while the other moisturizer (complex cream) affects only expression of cyclin-dependent kinase inhibitor 1A
additional information
no expression in liver, pancreas, small intestine, bone marrow, ovary, skeletal muscle, spleen, colon, adrenal gland, prostate, heart, lung, and stomach
additional information
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no expression in liver, pancreas, small intestine, bone marrow, ovary, skeletal muscle, spleen, colon, adrenal gland, prostate, heart, lung, and stomach
additional information
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enzyme is specifically expressed in keratinizing squamous epithelia
additional information
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no expression of kallikrein 7 by normal cervical keratinocytes
additional information
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KLK7 tissue expression and distribution pattern, overview
additional information
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mRNA levels of KLK7 in normal breast tissues, benign breast tissues, primary tumors, and lymph node metastases, by real-time RT-PCR and microarray, detailed overview
additional information
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tissue expression analysis by quantitative RT PCR analysis
additional information
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the enzyme is overexpressed in a variety of cancers, significantly increased serum enzyme levels with cervical cancer
additional information
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tissue expression analysis by quantitative RT PCR analysis
