3.4.21.117: stratum corneum chymotryptic enzyme
This is an abbreviated version!
For detailed information about stratum corneum chymotryptic enzyme, go to the full flat file.
Word Map on EC 3.4.21.117
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3.4.21.117
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klk7
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desquamation
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keratinocytes
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cornified
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corneocyte
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netherton
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corneodesmosomes
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desmogleins
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corneodesmosin
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spink5
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medicine
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desmocollin
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vaspin
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diagnostics
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molecular biology
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desquamatory
- 3.4.21.117
- klk7
-
desquamation
- keratinocytes
-
cornified
- corneocyte
- netherton
-
corneodesmosomes
-
desmogleins
- corneodesmosin
-
spink5
- medicine
-
desmocollin
- vaspin
- diagnostics
- molecular biology
-
desquamatory
Reaction
cleavage of proteins with aromatic side chains in the P1 position =
Synonyms
hK7, HSCCE, human stratum corneum chymotryptic enzyme, K7, kallikrein 7, kallikrein-7, kallikrein-related peptidase, kallikrein-related peptidase 7, KLK7, More, S01.300, SCCE, stratum corneum chymotryptic enzyme, tissue kallikrein, tissue kallikrein 7
ECTree
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Posttranslational Modification
Posttranslational Modification on EC 3.4.21.117 - stratum corneum chymotryptic enzyme
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glycoprotein
proteolytic modification
recombinant enzyme proform is activated by digestion with trypsin
proteolytic modification
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activation by thermolysin, inhibited by phosphoramidon
proteolytic modification
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activation of recombinant pro-kallikrein 7 by thermolysin, inhibited by phosphoramidon
proteolytic modification
pro-kallikrein is activated by proteolytic clavage of the Xaa15-Ile16 bond
proteolytic modification
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proKLK7 is processed and activated by meprin metalloproteases alpha and beta, which need to activated themselves by specifically by KLK4, KLK5, and KLK8, overview. Meprins cleave within the N-terminal region of proKLK7. This triggering leads to an accelerated activation of KLK7 (approximately 150%) in the presence of trypsin, overview