3.4.21.114: equine arterivirus serine peptidase

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For detailed information about equine arterivirus serine peptidase, go to the full flat file.

Word Map on EC 3.4.21.114

3.4.21.114

rotavirus

enterotoxin

prrsv

gastroenteritis

chikungunya

replicase

vp4

chikvs

rotavirus-infected

nsp3

viroporins

astrovirus

hp-prrsv

anti-prrsv

rv-induced

Reaction

cleavage of (Glu/Gln)-/-(Gly/Ser/Ala) in arterivirus replicase translation products ORF1a and ORF1ab =

Synonyms

3C-like serine protease, 3CLSP, equine arteritis virus serine endopeptidase, non-structural protein 4, nonstructural protein 4, nsp4, nsp4 serine protease, nsp4SP, S32.001

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.114 equine arterivirus serine peptidase

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Results	in table
4	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
2	Crystallization (Commentary)
5	General Information
1	KM Value [mM]
2	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
16	Organism
2	PDB ID
1	pH Optimum
3	Posttranslational Modification
26	Protein Variants
3	Purification (Commentary)
1	Reaction
17	Reaction Type
15	Reference
26	Substrates and Products (Substrate)
1	Subunits
29	Synonyms
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.21.114 - equine arterivirus serine peptidase

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arterivirus replicase ORF1a + H2O

equine arteritis virus

ORF1a can be cleaved following two alternative pathways. In the majority nsp3-8 precursors are cleaved at the nsp4/5 site yielding nsp3-4 and nsp5-8. The latter product is then cleaved at nsp7/8 only. In the alternative proteolytic cascade the nsp4/5 site remains uncleaved while the nsp5/6 and nsp6/7 sites are processed. nsp3-8 has to interact with cleaved nsp2 to allow processing of the nsp4/5 junction, when nsp2 cofactor is absent the alternative pathway is used

653065

proform caspase-3 + H2O

mature caspase-3 + ?

porcine reproductive and respiratory syndrome virus

Q91F54

activation

732736

proform caspase-8 + H2O

mature caspase-8 + ?

porcine reproductive and respiratory syndrome virus

Q91F54

activation

732736

proform caspase-9 + H2O

mature caspase-9 + ?

porcine reproductive and respiratory syndrome virus

Q91F54

activation

732736

additional information

4 entries