3.4.21.114: equine arterivirus serine peptidase
This is an abbreviated version!
For detailed information about equine arterivirus serine peptidase, go to the full flat file.
Word Map on EC 3.4.21.114
-
3.4.21.114
-
rotavirus
-
enterotoxin
-
prrsv
-
gastroenteritis
-
chikungunya
-
replicase
-
vp4
-
chikvs
-
rotavirus-infected
-
nsp3
-
viroporins
-
astrovirus
-
hp-prrsv
-
anti-prrsv
-
rv-induced
- 3.4.21.114
- rotavirus
- enterotoxin
- prrsv
- gastroenteritis
-
chikungunya
-
replicase
- vp4
-
chikvs
-
rotavirus-infected
- nsp3
-
viroporins
- astrovirus
-
hp-prrsv
-
anti-prrsv
-
rv-induced
Reaction
cleavage of (Glu/Gln)-/-(Gly/Ser/Ala) in arterivirus replicase translation products ORF1a and ORF1ab =
Synonyms
3C-like serine protease, 3CLSP, equine arteritis virus serine endopeptidase, non-structural protein 4, nonstructural protein 4, nsp4, nsp4 serine protease, nsp4SP, S32.001
ECTree
Advanced search results
General Information
General Information on EC 3.4.21.114 - equine arterivirus serine peptidase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
malfunction
the ability of nsp4 to induce apoptosis is significantly impaired by His39, Asp64, and Ser118 mutations
physiological function
additional information
porcine reproductive and respiratory syndrome virus nonstructural protein 4 is a critical apoptosis inducer dependent on its serine protease activity, the full-length of nsp4 structure is required for its apoptosis-inducing activity, the enzyme can induce apoptosis in diverse cell lines, e.g. in HeLa cells, overview
physiological function
-
nsp4 inhibits virus-induced IFN-beta production by targeting NF-kappaB essential modulator NEMO for proteolytic cleavage. The scission occurs at sites E166, E171, Q205, and E349
physiological function
nsp4 inhibits virus-induced IFN-beta production by targeting NF-kappaB essential modulator NEMO for proteolytic cleavage. The scission occurs at sites E166, E171, Q205, and E349. NEMO cleavage at E349 alone may not be sufficient to completely inactivate the interferon response via this signaling adaptor
residues His39, Asp64, and Ser118 are essential for the enzyme to trigger apoptosis
additional information
-
residues His39, Asp64, and Ser118 are essential for the enzyme to trigger apoptosis