3.4.21.114: equine arterivirus serine peptidase
This is an abbreviated version!
For detailed information about equine arterivirus serine peptidase, go to the full flat file.
Word Map on EC 3.4.21.114
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3.4.21.114
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rotavirus
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enterotoxin
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prrsv
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gastroenteritis
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chikungunya
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replicase
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vp4
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chikvs
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rotavirus-infected
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nsp3
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viroporins
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astrovirus
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hp-prrsv
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anti-prrsv
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rv-induced
- 3.4.21.114
- rotavirus
- enterotoxin
- prrsv
- gastroenteritis
-
chikungunya
-
replicase
- vp4
-
chikvs
-
rotavirus-infected
- nsp3
-
viroporins
- astrovirus
-
hp-prrsv
-
anti-prrsv
-
rv-induced
Reaction
cleavage of (Glu/Gln)-/-(Gly/Ser/Ala) in arterivirus replicase translation products ORF1a and ORF1ab =
Synonyms
3C-like serine protease, 3CLSP, equine arteritis virus serine endopeptidase, non-structural protein 4, nonstructural protein 4, nsp4, nsp4 serine protease, nsp4SP, S32.001
ECTree
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Engineering
Engineering on EC 3.4.21.114 - equine arterivirus serine peptidase
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D1129E
mutant is able to cleave the Nsp4/5 site with wild-type efficiently but does not process the Nsp3/4 and Nsp5/6 junctions
S1184I
T1179N
retains wild-type activity towards Nsp4/5, cleaves Nsp5/6 with increased efficiency
D64A
site-directed mutagenesis, the mutant shows significantly reduced ability to induce apoptosis compared to the wild-type enzyme
H39A
site-directed mutagenesis, the mutant shows significantly reduced ability to induce apoptosis compared to the wild-type enzyme
S118A
catalytic residue, mutant protein inactive
S118A
site-directed mutagenesis, the mutant shows significantly reduced ability to induce apoptosis compared to the wild-type enzyme