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3.4.21.113: pestivirus NS3 polyprotein peptidase

This is an abbreviated version!
For detailed information about pestivirus NS3 polyprotein peptidase, go to the full flat file.

Word Map on EC 3.4.21.113

Reaction

Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites =

Synonyms

border disease virus NS3 endopeptidase, BVD NS3 endopeptidase, BVDV NS3 endopeptidase, classical swine fever virus NS3 endopeptidase, CSFV NS3, CSFV NS3 endopeptidase, flavivirus NS3 protease, nonstructural protein 3, nonstructural protein NS3, NS2B/NS3 protease, NS3, NS3 protease, NS3 protein, NS3 proteinase, NS3 serine protease, NS3-4A protease, NS3-SP, NS3prohelx, P80pestivirus P80 protein, pestivirus NS3 protease, S31.001, viral diarrhea virus endopeptidase, WNV NS2B/NS3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.113 pestivirus NS3 polyprotein peptidase

Reference

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Reference on EC 3.4.21.113 - pestivirus NS3 polyprotein peptidase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Xu, J.; Mendez, E.; Caron, P.R.; Lin, C.; Murcko, M.A.; Collett, M.S.; Rice, C.M.
Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication
J. Virol.
71
5312-5322
1997
Bovine viral diarrhea virus 1, Bovine viral diarrhea virus 1 NADL
Manually annotated by BRENDA team
Tautz, N.; Elbers, K.; Stoll, D.; Meyers, G.; Thiel, H.J.
Serine protease of pestiviruses: determination of cleavage sites
J. Virol.
71
5415-5422
1997
Bovine viral diarrhea virus 1, Bovine viral diarrhea virus 1 CP7
Manually annotated by BRENDA team
Deng, R.; Brock, K.V.
Molecular cloning and nucleotide sequence of a pestivirus genome, noncytopathic bovine viral diarrhea virus strain SD-1
Virology
191
867-869
1992
Bovine viral diarrhea virus 1 (Q01499), Bovine viral diarrhea virus 1 SD-1 (Q01499)
Manually annotated by BRENDA team
Tautz, N.; Kaiser, A.; Thiel, H.J.
NS3 serine protease of bovine viral diarrhea virus: characterization of active site residues, NS4A cofactor domain, and protease-cofactor interactions
Virology
273
351-363
2000
Bovine viral diarrhea virus 1
Manually annotated by BRENDA team
Chen, K.X.; Njoroge, F.G.; Arasappan, A.; Venkatraman, S.; Vibulbhan, B.; Yang, W.; Parekh, T.N.; Pichardo, J.; Prongay, A.; Cheng, K.C.; Butkiewicz, N.; Yao, N.; Madison, V.; Girijavallabhan, V.
Novel potent hepatitis C virus NS3 serine protease inhibitors derived from proline-based macrocycles
J. Med. Chem.
49
995-1005
2006
Hepacivirus C
Manually annotated by BRENDA team
Wiskerchen, M.; Collett, M.S.
Pestvirus gene expression: protein p80 of bovine viral diarrhea virus is a proteinase involved in polyprotein processing
Virology
184
341-350
1991
Bovine viral diarrhea virus 1
Manually annotated by BRENDA team
Zuo, G.; Li, Z.; Chen, L.; Xu, X.
Activity of compounds from Chinese herbal medicine Rhodiola kirilowii (Regel) Maxim against HCV NS3 serine protease
Antiviral Res.
76
86-92
2007
Hepacivirus C
Manually annotated by BRENDA team
Li, X.; Zhang, W.; Qiao, X.; Xu, X.
Prediction of binding for a kind of non-peptic HCV NS3 serine protease inhibitors from plants by molecular docking and MM-PBSA method
Bioorg. Med. Chem.
15
220-226
2007
Hepacivirus C
Manually annotated by BRENDA team
Chen, K.X.; Vibulbhan, B.; Yang, W.; Cheng, K.C.; Liu, R.; Pichardo, J.; Butkiewicz, N.; Njoroge, F.G.
Potent and selective small molecule NS3 serine protease inhibitors of Hepatitis C virus with dichlorocyclopropylproline as P2 residue
Bioorg. Med. Chem.
16
1874-1883
2008
Hepacivirus C
Manually annotated by BRENDA team
Beran, R.K.; Serebrov, V.; Pyle, A.M.
The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate
J. Biol. Chem.
282
34913-34920
2007
Hepacivirus C
Manually annotated by BRENDA team
Bogen, S.L.; Arasappan, A.; Bennett, F.; Chen, K.; Jao, E.; Liu, Y.T.; Lovey, R.G.; Venkatraman, S.; Pan, W.; Parekh, T.; Pike, R.E.; Ruan, S.; Liu, R.; Baroudy, B.; Agrawal, S.; Chase, R.; Ingravallo, P.; Pichardo, J.; Prongay, A.; Brisson, J.M.; Hsieh, T.Y.; Cheng, K.C.; Kemp, S.J.; Levy, O.E.; Lim-Wilby, M.; Tamura, S.Y.; Saksena, A.K.; Girijavallabhan, V.; Njoroge, F.G.
Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication
J. Med. Chem.
49
2750-2757
2006
Hepacivirus C
Manually annotated by BRENDA team
Chernov, A.V.; Shiryaev, S.A.; Aleshin, A.E.; Ratnikov, B.I.; Smith, J.W.; Liddington, R.C.; Strongin, A.Y.
The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase
J. Biol. Chem.
283
17270-17278
2008
West Nile virus (Q3HM13)
Manually annotated by BRENDA team
Condotta, S.A.; Martin, M.M.; Boutin, M.; Jean, F.
Detection and in-cell selectivity profiling of the full-length West Nile virus NS2B/NS3 serine protease using membrane-anchored fluorescent substrates
Biol. Chem.
391
549-559
2010
West Nile virus
Manually annotated by BRENDA team
Lim, H.A.; Joy, J.; Hill, J.; San Brian Chia, C.
Novel agmatine and agmatine-like peptidomimetic inhibitors of the West Nile virus NS2B/NS3 serine protease
Eur. J. Med. Chem.
46
3130-3134
2011
West Nile virus
Manually annotated by BRENDA team
Lamp, B.; Riedel, C.; Wentz, E.; Tortorici, M.A.; Ruemenapf, T.
Autocatalytic cleavage within classical swine fever virus NS3 leads to a functional separation of protease and helicase
J. Virol.
87
11872-11883
2013
Classical swine fever virus (P19712)
Manually annotated by BRENDA team
Riedel, C.; Lamp, B.; Heimann, M.; Koenig, M.; Blome, S.; Moennig, V.; Schuettler, C.; Thiel, H.J.; Ruemenapf, T.
The core protein of classical Swine Fever virus is dispensable for virus propagation in vitro
PLoS Pathog.
8
e1002598
2012
Classical swine fever virus (P19712)
Manually annotated by BRENDA team
Zheng, F.; Lu, G.; Li, L.; Gong, P.; Pan, Z.
Uncoupling of protease trans-cleavage and helicase activities in pestivirus NS3
J. Virol.
91
e01094-17
2017
Classical swine fever virus (Q5U8X5), Classical swine fever virus
Manually annotated by BRENDA team
Dubrau, D.; Tortorici, M.A.; Rey, F.A.; Tautz, N.
A positive-strand RNA virus uses alternative protein-protein interactions within a viral protease/cofactor complex to switch between RNA replication and virion morphogenesis
PLoS Pathog.
13
e1006134
2017
Classical swine fever virus (Q5U8X5)
Manually annotated by BRENDA team