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Literature summary for 3.4.21.113 extracted from

  • Xu, J.; Mendez, E.; Caron, P.R.; Lin, C.; Murcko, M.A.; Collett, M.S.; Rice, C.M.
    Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication (1997), J. Virol., 71, 5312-5322.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.113

Activating Compound

Activating Compound Comment Organism Structure
additional information cofactor required for cleavage at the 4B/5A and 5A/5B sites Bovine viral diarrhea virus 1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bovine viral diarrhea virus polyprotein + H2O Bovine viral diarrhea virus 1 the enzyme is required for pestivirus replication. The enzyme is required for processing at nonstructural protein sites 3/4A, 4A/4B, 4B/5A and 5A/5B but not for cleavage at the junction between NS2 and NS3. A conserved Leu is found at the P1 position of all four cleavage sites, followed by either Ser (3/4A, 4B5A, and 5A/5B sites) or Ala (4A/4B site) at the P1' position ?
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 ?
bovine viral diarrhea virus polyprotein + H2O Bovine viral diarrhea virus 1 NADL the enzyme is required for pestivirus replication. The enzyme is required for processing at nonstructural protein sites 3/4A, 4A/4B, 4B/5A and 5A/5B but not for cleavage at the junction between NS2 and NS3. A conserved Leu is found at the P1 position of all four cleavage sites, followed by either Ser (3/4A, 4B5A, and 5A/5B sites) or Ala (4A/4B site) at the P1' position ?
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 ?

Organism

Organism UniProt Comment Textmining
Bovine viral diarrhea virus 1
-
 NADL strain
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Bovine viral diarrhea virus 1 NADL
-
 NADL strain
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bovine viral diarrhea virus polyprotein + H2O the enzyme is required for processing at nonstructural protein sites 3/4A, 4A/4B, 4B/5A and 5A/5B but not for cleavage at the junction between NS2 and NS3. A conserved Leu is found at the P1 position of all four cleavage sites, followed by either Ser (3/4A, 4B5A, and 5A/5B sites) or Ala (4A/4B site) at the P1' position Bovine viral diarrhea virus 1 ?
-
 ?
bovine viral diarrhea virus polyprotein + H2O the enzyme is required for pestivirus replication. The enzyme is required for processing at nonstructural protein sites 3/4A, 4A/4B, 4B/5A and 5A/5B but not for cleavage at the junction between NS2 and NS3. A conserved Leu is found at the P1 position of all four cleavage sites, followed by either Ser (3/4A, 4B5A, and 5A/5B sites) or Ala (4A/4B site) at the P1' position Bovine viral diarrhea virus 1 ?
-
 ?
bovine viral diarrhea virus polyprotein + H2O the enzyme is required for processing at nonstructural protein sites 3/4A, 4A/4B, 4B/5A and 5A/5B but not for cleavage at the junction between NS2 and NS3. A conserved Leu is found at the P1 position of all four cleavage sites, followed by either Ser (3/4A, 4B5A, and 5A/5B sites) or Ala (4A/4B site) at the P1' position Bovine viral diarrhea virus 1 NADL ?
-
 ?
bovine viral diarrhea virus polyprotein + H2O the enzyme is required for pestivirus replication. The enzyme is required for processing at nonstructural protein sites 3/4A, 4A/4B, 4B/5A and 5A/5B but not for cleavage at the junction between NS2 and NS3. A conserved Leu is found at the P1 position of all four cleavage sites, followed by either Ser (3/4A, 4B5A, and 5A/5B sites) or Ala (4A/4B site) at the P1' position Bovine viral diarrhea virus 1 NADL ?
-
 ?

Synonyms

Synonyms Comment Organism
NS3
-
 Bovine viral diarrhea virus 1
NS3 proteinase
-
 Bovine viral diarrhea virus 1