3.4.21.113: pestivirus NS3 polyprotein peptidase

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Reaction

Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites =

Synonyms

border disease virus NS3 endopeptidase, BVD NS3 endopeptidase, BVDV NS3 endopeptidase, classical swine fever virus NS3 endopeptidase, CSFV NS3, CSFV NS3 endopeptidase, flavivirus NS3 protease, nonstructural protein 3, nonstructural protein NS3, NS2B/NS3 protease, NS3, NS3 protease, NS3 protein, NS3 proteinase, NS3 serine protease, NS3-4A protease, NS3-SP, NS3prohelx, P80pestivirus P80 protein, pestivirus NS3 protease, S31.001, viral diarrhea virus endopeptidase, WNV NS2B/NS3

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.113 pestivirus NS3 polyprotein peptidase

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3	Activating Compound
7	AA Sequence
3	Application
1	CAS Registry Number
6	Cloned(Commentary)
1	Cofactor
4	Crystallization (Commentary)
14	General Information
13	IC50 Value
58	Inhibitors
47	Ki Value [mM]
14	Natural Substrates/ Products (Substrates)
21	Organism
22	PDB ID
1	pH Optimum
3	Posttranslational Modification
16	Protein Variants
5	Purification (Commentary)
1	Reaction
2	Reaction Type
21	Reference
22	Substrates and Products (Substrate)
1	Subunits
42	Synonyms

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Cloned on EC 3.4.21.113 - pestivirus NS3 polyprotein peptidase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Hepacivirus C

-

685513

complete genomic nucleotide sequence

Bovine viral diarrhea virus 1

Q01499

654010

expressed in Escherichia coli as a His-tagged fusion protein

West Nile virus

Q3HM13

698763

into plasmid pMANS34NSH and expressed in Escherichia coli JM109. Chimeric plasmid pCI-neo-NS3/4A-SEAP expressed in Cos-7 cells

Hepacivirus C

-

684506

into vectors pET15b and pET-SUMO

Hepacivirus C

-

687647

recombinant expression of His-tagged wild-type and mutant enzymes in Escherichia coli

Classical swine fever virus

Q5U8X5

755207