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Literature summary for 3.4.21.113 extracted from

  • Zuo, G.; Li, Z.; Chen, L.; Xu, X.
    Activity of compounds from Chinese herbal medicine Rhodiola kirilowii (Regel) Maxim against HCV NS3 serine protease (2007), Antiviral Res., 76, 86-92.
    View publication on PubMed
Search for more literature for 3.4.21.113

Application

Application Comment Organism
drug development nonpeptide inhibitors of NS3-SP from Chinese herbal medicine Rhodiola kirilowii may serve as potential candidate anti-hepatitis C virus agents. Cell viability and secreted alkaline phosphatase (SEAP) activity assays with the nonpeptide inhibitors of NS3-SP reveal little if any toxicity Hepacivirus C

Cloned(Commentary)

Cloned (Comment) Organism
into plasmid pMANS34NSH and expressed in Escherichia coli JM109. Chimeric plasmid pCI-neo-NS3/4A-SEAP expressed in Cos-7 cells Hepacivirus C

Inhibitors

Inhibitors Comment Organism Structure
3,3'-digalloylprocyanidin B2 nonpeptide inhibitor of NS3-SP from Rhodiola kirilowii. Methylation and acylation of hydroxyl groups cause a decrease of activity Hepacivirus C
3,3'-digalloylproprodelphinidin B2 nonpeptide inhibitor of NS3-SP from Rhodiola kirilowii. Methylation and acylation of hydroxyl groups cause a decrease of activity Hepacivirus C
epicatechin-3-O-gallate nonpeptide inhibitor of NS3-SP from Rhodiola kirilowii. Methylation and acylation of hydroxyl groups cause a decrease of activity Hepacivirus C
epigallocatechin-3-O-gallate nonpeptide inhibitor of NS3-SP from Rhodiola kirilowii. Methylation and acylation of hydroxyl groups cause a decrease of activity Hepacivirus C
additional information salidroside shows no activity up to 0.1 mM Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Hepacivirus C

Synonyms

Synonyms Comment Organism
NS3 serine protease
-
 Hepacivirus C
NS3-SP
-
 Hepacivirus C

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00077
-
-
 Hepacivirus C 3,3'-digalloylproprodelphinidin B2
0.00091
-
-
 Hepacivirus C 3,3'-digalloylprocyanidin B2
0.00851
-
-
 Hepacivirus C epigallocatechin-3-O-gallate
0.01855
-
-
 Hepacivirus C epicatechin-3-O-gallate