3.4.21.113: pestivirus NS3 polyprotein peptidase

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For detailed information about pestivirus NS3 polyprotein peptidase, go to the full flat file.

Reaction

Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites =

Synonyms

border disease virus NS3 endopeptidase, BVD NS3 endopeptidase, BVDV NS3 endopeptidase, classical swine fever virus NS3 endopeptidase, CSFV NS3, CSFV NS3 endopeptidase, flavivirus NS3 protease, nonstructural protein 3, nonstructural protein NS3, NS2B/NS3 protease, NS3, NS3 protease, NS3 protein, NS3 proteinase, NS3 serine protease, NS3-4A protease, NS3-SP, NS3prohelx, P80pestivirus P80 protein, pestivirus NS3 protease, S31.001, viral diarrhea virus endopeptidase, WNV NS2B/NS3

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.113 pestivirus NS3 polyprotein peptidase

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Results	in table
3	Activating Compound
7	AA Sequence
3	Application
1	CAS Registry Number
6	Cloned(Commentary)
1	Cofactor
4	Crystallization (Commentary)
14	General Information
13	IC50 Value
58	Inhibitors
47	Ki Value [mM]
14	Natural Substrates/ Products (Substrates)
21	Organism
22	PDB ID
1	pH Optimum
3	Posttranslational Modification
16	Protein Variants
5	Purification (Commentary)
1	Reaction
2	Reaction Type
21	Reference
22	Substrates and Products (Substrate)
1	Subunits
42	Synonyms

Sequence

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Sequence on EC 3.4.21.113 - pestivirus NS3 polyprotein peptidase

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTIONThe reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

Q96662 pBLAST

POLG_BVDVC

Bovine viral diarrhea virus (strain CP7)

3907

10

439104

Swiss-Prot

Show Sequence

other Location (Reliability: 1)

P19711 pBLAST

POLG_BVDVN

Bovine viral diarrhea virus (isolate NADL)

3988

8

449163

Swiss-Prot

Show Sequence

other Location (Reliability: 1)

Q01499 pBLAST

POLG_BVDVS

Bovine viral diarrhea virus (strain SD-1)

3898

8

437808

Swiss-Prot

Show Sequence

other Location (Reliability: 1)

P19712 pBLAST

POLG_CSFVA

Classical swine fever virus (strain Alfort)

3898

8

438578

Swiss-Prot

Show Sequence

other Location (Reliability: 1)

P21530 pBLAST

POLG_CSFVB

Classical swine fever virus (strain Brescia)

3898

10

438430

Swiss-Prot

Show Sequence

other Location (Reliability: 1)

Q3HM13 pBLAST

Q3HM13_WNV

West Nile virus

3433

0

381142

TrEMBL

Show Sequence

other Location (Reliability: 1)

Q5U8X5 pBLAST

Q5U8X5_9FLAV

Classical swine fever virus

3898

0

437835

TrEMBL

Show Sequence

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