Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the central region of NS4A represents the cofactor domain | Bovine viral diarrhea virus 1 |
Protein Variants | Comment | Organism |
---|---|---|
D1686G | mutation does not induce obvious changes in processing | Bovine viral diarrhea virus 1 |
D1695A | mutation does not induce obvious changes in processing | Bovine viral diarrhea virus 1 |
additional information | the NS3 protease is sensitive to N-terminal truncation because a deletion of 6 amino acids significantly reduces the cleavage efficiency at the NS4A/4B site | Bovine viral diarrhea virus 1 |
S1752C | mutant enzyme exhibits only cleavage activity at the NS3/4A site | Bovine viral diarrhea virus 1 |
S1752T | mutant enzyme exhibits only cleavage activity at the NS3/4A site | Bovine viral diarrhea virus 1 |
S1752T | mutant enzyme still shows residual activity | Bovine viral diarrhea virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bovine viral diarrhea virus 1 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bovine viral diarrhea virus polyprotein + H2O | cleavages leading to the release of NS4A, NS4B, NS5A, and NS5B | Bovine viral diarrhea virus 1 | ? | - |
? | |
additional information | His1678, Asp1686 and Ser1752 constitute the catalytic triad | Bovine viral diarrhea virus 1 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NS3 serine protease | - |
Bovine viral diarrhea virus 1 |