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3.4.21.109: matriptase

This is an abbreviated version!
For detailed information about matriptase, go to the full flat file.

Word Map on EC 3.4.21.109

Reaction

cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position =

Synonyms

Epi/MTP, epithin, epithin/matriptase, influenza virus-activating protease, matriptase, matriptase-1, matriptase-2, matriptase-3, matriptase1, matriptase1a, membrane-type serine protease 1, membrane-type serine protease 1/matripase, membrane-type serine protease-1, membrane-type serine protease1, membrane-type serine proteinase matripase, membrane-type serine proteinase matriptase, More, MT-2, MT-SP-1, MT-SP1, MT-SP1/matripase, MT2, notopleural, prostamin, PRSS14, r-matripase, serine protease matriptase-2, serine protease SNC19/matripase, SNC19, ST-14, ST14, suppression of tumorigenecity 14, suppressor of tumorigenicity 14, suppressor of tumorigenicity 14 protein, suppressor of tumorigenicity-14, TADG-15, TADG15, TMPRSS6, transmembrane serine protease 6, tumor-associated differentially expressed gene-15, tumor-associated type II transmembrane serine protease, type 2 transmembrane serine protease, type II transmembrane protease, type II transmembrane serine protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.109 matriptase

KM Value

KM Value on EC 3.4.21.109 - matriptase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
35.5
ABZ-Ile-Arg-Ala-Arg-Ser-Ala-Ala-Tyr(3-NO2)-NH2
pH and temperature not specified in the publication
8.35
ABZ-Ile-Arg-Ala-Arg-Ser-Ala-Gly-Tyr(3-NO2)-NH2
pH and temperature not specified in the publication
24.5
ABZ-Ile-Arg-Ala-Arg-Ser-Ala-Ser-Tyr(3-NO2)-NH2
pH and temperature not specified in the publication
0.1 - 0.111
alphaEbeta7 integrin
-
0.024 - 1
Boc-Gln-Ala-Arg-4-nitroanilide
0.159 - 0.381
butyloxycarbonyl-L-Gln-L-Ala-L-Arg-4-nitroanilide
0.03 - 0.046
filaggrin
-
0.256 - 0.387
Ile-Pro-Arg-p-nitroanilide
0.104 - 0.126
matriptase
-
0.17 - 0.19
methylsulfonyl-D-cyclohexyltyrosyl-glycyl-arginine-p-nitroanilide
0.164 - 0.228
methylsulfonyl-D-cyclohexyltyrosylglycyl-arginine-p-nitroanilide
0.0699
N-succinyl-Ala-Phe-Lys-7-amido-4-methylcoumarin
pH 8.5
0.00381
N-tert-butoxycarbonyl-gamma-benzyl-Glu-Ala-Arg-7-amido-4-methylcoumarin
pH 8.5
0.0475
N-tert-butoxycarbonyl-gamma-benzyl-Glu-Gly-Arg-7-amido-4-methylcoumarin
pH 8.5
0.00489 - 0.0335
N-tert-butoxycarbonyl-Gln-Ala-Arg 7-amido-4-methylcoumarin
0.0136
N-tert-butoxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin
pH 8.5
0.0017
pro-urokinase plasminogen activator
-
-
-
0.142 - 0.197
protease-activated receptor-2
-
0.159
RAARVVGG
-
-
0.088
RLARVVGG
-
-
0.018 - 0.128
RQARAVGG
0.065
RQARQVGG
-
-
0.104 - 0.126
RQARVVGG
0.869
RQARYVGG
-
-
0.124
RQLRVVGG
-
-
0.05
RQRRVVGG
-
-
0.05
RQYRVVGG
-
-
0.0033 - 0.012
RRARVVGG
0.137
RYARVVGG
-
-
0.00352 - 0.00599
single-chain urokinase-type plasminogen activator
-
240
Suc-Ala-Ala-Pro-Arg-p-nitroanilide
-
-
534
Suc-Ala-Ala-Pro-Lys-p-nitroanilide
-
-
0.582 - 0.59
t-butyloxycarbonyl-L-Gln-L-Ala-L-Arg-4-methyl-coumaryl-7-amide
0.052 - 0.07
trask
-
additional information
additional information
-