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3.4.21.109: matriptase

This is an abbreviated version!
For detailed information about matriptase, go to the full flat file.

Word Map on EC 3.4.21.109

Reaction

cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position =

Synonyms

Epi/MTP, epithin, epithin/matriptase, influenza virus-activating protease, matriptase, matriptase-1, matriptase-2, matriptase-3, matriptase1, matriptase1a, membrane-type serine protease 1, membrane-type serine protease 1/matripase, membrane-type serine protease-1, membrane-type serine protease1, membrane-type serine proteinase matripase, membrane-type serine proteinase matriptase, More, MT-2, MT-SP-1, MT-SP1, MT-SP1/matripase, MT2, notopleural, prostamin, PRSS14, r-matripase, serine protease matriptase-2, serine protease SNC19/matripase, SNC19, ST-14, ST14, suppression of tumorigenecity 14, suppressor of tumorigenicity 14, suppressor of tumorigenicity 14 protein, suppressor of tumorigenicity-14, TADG-15, TADG15, TMPRSS6, transmembrane serine protease 6, tumor-associated differentially expressed gene-15, tumor-associated type II transmembrane serine protease, type 2 transmembrane serine protease, type II transmembrane protease, type II transmembrane serine protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.109 matriptase

Purification

Purification on EC 3.4.21.109 - matriptase

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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
activated matriptase-3 serine protease domain expressed in Spodoptera frugiperda Sf9 cells
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by immobilized metal-chelate affinity chromatography
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by immobilized metal-chelate affinity chromatography and ion exchange chromatography
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by molecular-sieve chromatography, reverse-phase HPLC
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from human milk using a CM-Sepharose FF column and a HAI-1 immunoaffinity column
from N-acetylglucosminyltransferase V transfectant by immunoaffinity chromatography
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native enzyme from colon carcinoma cell line DLD-1 by gel filtration, dialysis, adsorption chromatography, abion exchange chromatography, and freeze-drying
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partial
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purified from the conditioned medium using Ni-NTA chromatography
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recombinant c-Myc-tagged enzyme from HEK cells by immunoaffinity chromatography
recombinant His-tagged amino acids 596-855 of matriptase from Escherichia coli strain M15 by metal affinity chromatography, dialysis, and anion exchange chromatography
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recombinant refolded His-tagged matriptase catalytic domain nickel affinity chromatography
recombinant truncated wild-type zymogen and mutant G287R from Escherichia coli
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using a metal chelating column and a gel filtration column
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vector pcMT-SP1 MycHis by Ni2+ charged resin
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