Protein Variants | Comment | Organism |
---|---|---|
D217A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
D60A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
D96A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
E169A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
F94A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
F97A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
F99A | site-directed mutagenesis, inactive mutant | Homo sapiens |
H143A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
I41A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
I60A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
K224A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
L153A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
N95A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
Q145A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
Q174A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
Q175A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
Q192A | site-directed mutagenesis, inactive mutant | Homo sapiens |
Q221A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
Q38A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
R222A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
R60A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
R87A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
T150A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
T98A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
W215A | site-directed mutagenesis, inactive mutant | Homo sapiens |
Y146A | site-directed mutagenesis, the mutant shows altered inhibition kinetics with different inhibitors, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-aminobenzamidine | weak competitive inhibition, competition assay with antibody inhibitors, overview | Homo sapiens | |
Bovine pancreatic trypsin inhibitor | BPTI | Homo sapiens | |
scFv antibody E2 | competitive mechanism of inhibition of the scFv antibody enzyme inhibitors, which competes with substrate binding in the S1 site, the antibody binds to a number of residues flanking the active site, forming a unique three-dimensional binding epitope | Homo sapiens | |
scFv antibody S4 | competitive mechanism of inhibition of the scFv antibody enzyme inhibitors, which competes with substrate binding in the S1 site, the antibody binds to a number of residues flanking the active site, forming a unique three-dimensional binding epitope | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | pre-steady-state and steady-state kinetics, stopped-flow, overview | Homo sapiens | |
0.0017 | - |
pro-urokinase plasminogen activator | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-urokinase plasminogen activator + H2O | Homo sapiens | - |
urokinase plasminogen activator + propeptide of urokinase plasminogen activator | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-urokinase plasminogen activator + H2O | - |
Homo sapiens | urokinase plasminogen activator + propeptide of urokinase plasminogen activator | - |
? |
Synonyms | Comment | Organism |
---|---|---|
membrane-type serine protease 1 | - |
Homo sapiens |
MT-SP1 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.89 | - |
pro-urokinase plasminogen activator | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics with antobodies E2 and S4 and point mutants thereof, overview | Homo sapiens | |
0.0000000123 | - |
scFv antibody E2 | - |
Homo sapiens | |
0.0000000497 | - |
Bovine pancreatic trypsin inhibitor | - |
Homo sapiens | |
0.0000000704 | - |
scFv antibody S4 | - |
Homo sapiens | |
0.0288 | - |
4-aminobenzamidine | - |
Homo sapiens |