3.4.21.109: matriptase
This is an abbreviated version!
For detailed information about matriptase, go to the full flat file.
Word Map on EC 3.4.21.109
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3.4.21.109
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hepatocyte
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hepcidin
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hai-1
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anemia
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metastasis
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prostate
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hepsin
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zymogen
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transferrin
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prostasin
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overload
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trypsin-like
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irida
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plasminogen
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hemojuvelin
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iron-refractory
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kunitz-type
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inhibitor-1
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kunitz
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ttsps
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hemochromatosis
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erythropoiesis
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microcytic
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membrane-anchored
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urokinase-type
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ferroportin
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iron-deficiency
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pro-hgf
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pericellular
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upa
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autoactivation
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two-chain
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hypochromic
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medicine
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protease-activated
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tmprss4
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spint2
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corpuscular
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erythroferrone
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profilaggrin
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camostat
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corin
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epithelial-derived
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par-2
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hypotrichosis
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drug development
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diagnostics
- 3.4.21.109
- hepatocyte
- hepcidin
- hai-1
- anemia
- metastasis
- prostate
- hepsin
- zymogen
- transferrin
- prostasin
- overload
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trypsin-like
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irida
- plasminogen
- hemojuvelin
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iron-refractory
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kunitz-type
- inhibitor-1
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kunitz
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ttsps
- hemochromatosis
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erythropoiesis
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microcytic
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membrane-anchored
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urokinase-type
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ferroportin
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iron-deficiency
- pro-hgf
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pericellular
- upa
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autoactivation
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two-chain
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hypochromic
- medicine
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protease-activated
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tmprss4
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spint2
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corpuscular
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erythroferrone
- profilaggrin
- camostat
- corin
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epithelial-derived
- par-2
- hypotrichosis
- drug development
- diagnostics
Reaction
cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position =
Synonyms
Epi/MTP, epithin, epithin/matriptase, influenza virus-activating protease, matriptase, matriptase-1, matriptase-2, matriptase-3, matriptase1, matriptase1a, membrane-type serine protease 1, membrane-type serine protease 1/matripase, membrane-type serine protease-1, membrane-type serine protease1, membrane-type serine proteinase matripase, membrane-type serine proteinase matriptase, More, MT-2, MT-SP-1, MT-SP1, MT-SP1/matripase, MT2, notopleural, prostamin, PRSS14, r-matripase, serine protease matriptase-2, serine protease SNC19/matripase, SNC19, ST-14, ST14, suppression of tumorigenecity 14, suppressor of tumorigenicity 14, suppressor of tumorigenicity 14 protein, suppressor of tumorigenicity-14, TADG-15, TADG15, TMPRSS6, transmembrane serine protease 6, tumor-associated differentially expressed gene-15, tumor-associated type II transmembrane serine protease, type 2 transmembrane serine protease, type II transmembrane protease, type II transmembrane serine protease
ECTree
3.4.21.109 matriptaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.21.109 - matriptase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acid-sensing ion channel 1 + H2O
?
-
the matriptase recognition sites Arg-145, Lys-185, and Lys-384 are identified in the specific substrate acid-sensing ion channel 1
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-
?
butyloxycarbonyl-L-Gln-L-Ala-L-Arg-4-nitroanilide + H2O
butyloxycarbonyl-L-Gln-L-Ala-L-Arg + 4-nitroaniline
-
-
-
-
?
epidermal growth factor receptor + H2O
EGFR135 + EGFR110
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the epidermal growth factor receptor, EGFR is proteolytically cleaved in the N-terminal extracellular domain by the matriptase-prostasin serine protease cascade in cultured epithelial cells
fragments of 135 and 110 kDa, no longer responsive to EGF stimulation
-
?
hepatocyte growth factor/scatter factor + H2O
activated hepatocyte growth factor/scatter factor + ?
HGF/SF + H2O
?
-
i.e. hepatocyte growth factor/scatter factor, growth factor
-
-
?
influenza A H1 virus hemagglutinin + H2O
?
the soluble form of the protease is able to specifically cleave hemagglutinins from H1 virus, but not from H2 and H3 viruses, in a broad pH range
-
-
?
pro matrix metalloproteinase 1 + H2O
?
-
matriptase activates pro-matrix metalloproteinase-1 and processes pro-matrix metalloproteinase-3 to its fully active form
-
-
?
pro matrix metalloproteinase 3 + H2O
?
-
matriptase activates pro-matrix metalloproteinase-1 and processes pro-matrix metalloproteinase-3 to its fully active form
-
-
?
pro-form GPI-anchored serine protease prostasin + H2O
mature GPI-anchored serine protease prostasin + ?
activation, prostasin is also a regulator of the epidermal sodium channel like matriptase
-
-
?
pro-form influenza hemagglutinin H1 + H2O
mature influenza hemagglutinin H1 + ?
-
-
-
?
pro-form matriptase + H2O
mature matriptase + ?
autocatalytic activation
-
-
?
pro-HGF + H2O
?
-
matriptase is an efficient activator of hepatocyte growth factor
-
-
?
pro-urokinase plasminogen activator + H2O
urokinase plasminogen activator + propeptide of urokinase plasminogen activator
proform epithelial sodium channel + H2O
mature epithelial sodium channel + ?
-
-
-
-
?
proform G protein-coupled protease activated receptor-2 + H2O
mature G protein-coupled protease activated receptor-2 + ?
-
-
-
-
?
proform hepatocyte growth factor + H2O
mature hepatocyte growth factor + ?
-
-
-
-
?
proform matriptase + H2O
mature matriptase
matriptase is expressed as a zymogen and is autocatalytically processed and activated through cleavage at Arg614 within the RQAR614-VVGG activation sequence
-
-
?
proform matriptase-2 + H2O
mature matriptase
matriptase-2 is expressed as zymogen form and undergoes autocatalysis at Arg576 within the PSSR576-IVGG sequence located in the consensus activation site of its pro-domain
-
-
?
prostasin + H2O
activated prostasin + ?
-
proteolytic activation by matriptase, when expressed without matriptase, prostasin remains in the zymogen form and no prostasin-PN-1 complex is formed, overview
-
-
?
stromelysin + H2O
activated stromelysin + propeptide of stromelysin
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activation
-
-
?
urokinase plasminogen activator + H2O
urokinase plasminogen activator + propeptide of urokinase plasminogen activator
hemojuvelin + H2O
?
a glycosylphosphatidylinositol-linked membrane protein. inactivation
-
-
?
hepatocyte growth factor + H2O
activated hepatocyte growth factor + ?
-
proteolytic activation of hepatocyte growth factor/scatter factor, physiological function, overview
-
-
?
hepatocyte growth factor + H2O
activated hepatocyte growth factor + ?
-
proteolytic activation of hepatocyte growth factor/scatter factor, overview
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-
?
hepatocyte growth factor/scatter factor + H2O
activated hepatocyte growth factor/scatter factor + ?
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activation
-
-
?
hepatocyte growth factor/scatter factor + H2O
activated hepatocyte growth factor/scatter factor + ?
-
seven proteases are involved in the activation of HGF/SF, involved in cell proliferation and adhesion, ECM degradation/remodeling, and migration/invasiveness, overview
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-
?
hepatocyte growth factor/scatter factor + H2O
activated hepatocyte growth factor/scatter factor + ?
the enzyme is involved in tumor progression and metastasis
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-
?
hepatocyte growth factor/scatter factor + H2O
activated hepatocyte growth factor/scatter factor + ?
-
seven proteases are involved in the activation of HGF/SF, involved in cell proliferation and adhesion, ECM degradation/remodeling, and migration/invasiveness, overview
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-
?
IGFBP-rP1 + H2O
?
-
involved in involved in cell proliferation and adhesion
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-
?
IGFBP-rP1 + H2O
?
-
involved in involved in cell proliferation and adhesion
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-
?
insulin-like growth factor binding protein related protein-1
?
-
IGFBP-rP1
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-
?
insulin-like growth factor binding protein related protein-1
?
IGFBP-rP1
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-
?
insulin-like growth factor binding protein-related protein-1 + H2O
?
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activation
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-
?
insulin-like growth factor binding protein-related protein-1 + H2O
?
-
proteolytical cleavage on the cell surface of a a single-chain IGFB-rP1 to a two-chain form, consisting of a 25 kDa chain and an 8 kDa chain, changing its biological in modulation of cellular adhesion and growth in an IGF/insulin-dependent or independent manner, as well as tumor-suppressive activity, the soluble form of active matriptase cleaves IGFBP-rP1 but HAI-1 or some other inhibitors block its activity in culture medium, overview
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-
?
pro-prostasin + H2O
prostasin + propeptide of prostasin
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soluble matriptase efficiently converts soluble prostasin zymogen to an active two-chain form, prostasin is exclusively found in the zymogen form in matriptase-deficient epidermis
-
-
?
pro-prostasin + H2O
prostasin + propeptide of prostasin
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the channel activating protease prostasin/CAP1/PRSS8, a glycosylphosphatidylinositol-anchored membrane serine protease, is co-localized with matriptase
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-
?
pro-urokinase plasminogen activator + H2O
urokinase plasminogen activator + propeptide of urokinase plasminogen activator
-
-
-
-
?
pro-urokinase plasminogen activator + H2O
urokinase plasminogen activator + propeptide of urokinase plasminogen activator
-
activation
-
-
?
pro-urokinase plasminogen activator + H2O
urokinase plasminogen activator + propeptide of urokinase plasminogen activator
-
activation at the cell surface, where uPA and matriptase co-localize, involved in cell proliferation and adhesion, ECM degradation/remodeling, and migration/invasiveness
-
-
?
pro-urokinase plasminogen activator + H2O
urokinase plasminogen activator + propeptide of urokinase plasminogen activator
the enzyme is involved in tumor progression and metastasis
-
-
?
pro-urokinase plasminogen activator + H2O
urokinase plasminogen activator + propeptide of urokinase plasminogen activator
-
activation at the cell surface, where uPA and matriptase co-localize, involved in cell proliferation and adhesion, ECM degradation/remodeling, and migration/invasiveness
-
-
?
profilaggrin + H2O
filaggrin + propeptide of filaggrin
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involved in terminal epithelial cell differentiation, mechanism of enzyme access for direct cleavage in vivo, overview
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-
?
profilaggrin + H2O
filaggrin + propeptide of filaggrin
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involved in terminal epithelial cell differentiation, mechanism of enzyme access for direct cleavage in vivo, overview
-
-
?
urokinase plasminogen activator + H2O
urokinase plasminogen activator + propeptide of urokinase plasminogen activator
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pro-uPA activation on THP-1 cells
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-
?
urokinase plasminogen activator + H2O
urokinase plasminogen activator + propeptide of urokinase plasminogen activator
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pro-uPA activation
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-
?
VEGFR-2 + H2O
?
-
i.e. vascular endothelial growth factor receptor 2, a growth factor receptor
-
-
?
VEGFR-2 + H2O
?
-
i.e. vascular endothelial growth factor receptor 2, a growth factor receptor
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-
?
additional information
?
-
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enzyme inactivation by HAI-1 is required for epithelial integrity of the zebrafish epidermis, Hai1 and matriptase1a are involved in regualtion of skin homeostasis and remodeling, overview
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-
?
additional information
?
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degrades extracellular matrix, matriptase-binding protein is a Kunitz-type serine protease inhibitor
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?
additional information
?
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degrades extracellular matrix, matriptase-binding protein is a Kunitz-type serine protease inhibitor
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?
additional information
?
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initiator of matrix-degrading protein cascade, activates hepatocyte growth factor scattering factor
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?
additional information
?
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initiator of matrix-degrading protein cascade, activates hepatocyte growth factor scattering factor
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?
additional information
?
-
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involved in multiple aspects of tumor progression and cancer invasion
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?
additional information
?
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enzyme regulation and deregulation in cancer, overview, matriptase is involved in cancer initiation and progression, it not only facilitates cellular invasiveness but may also activate oncogenic pathways, overview
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-
?
additional information
?
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matriptase blockade could potentially modulate tumorigenesis and metastasis in vivo
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-
?
additional information
?
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matriptase cleaves and activates proteins implicated in the progression of cancer
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-
?
additional information
?
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matriptase expression is correlated with tumor progression in epithelium-derived cancer cells
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-
?
additional information
?
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-
matriptase has an essential physiological role in profilaggrin processing, corneocyte maturation, and lipid matrix formation associated with terminal differentiation of the oral epithelium and the epidermis, and is also critical for hair follicle growth, matriptase and HAI expression are frequently dysregulated in human cancer, and matriptase expression, that is unopposed by HAI-1, potently promotes carcinogenesis and metastatic dissemination in animal models, matriptase dramatically increases apoptosis of immature thymocytes in the thymus, leading to thymocyte depletion, physiological functions of matriptase, the enzyme is involved in epithelial carcinogenesis, detailed overview
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-
?
additional information
?
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-
matriptase is a type II transmembrane serine protease and highly regulated in leukocytes, and correlates with the presence of active uPA on their surface, it is up-regulated in a variety of cancers and correlates closely with disease progression, it acts as initiator of protease cascades/signaling pathways, overview
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-
?
additional information
?
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-
matriptase promotes tumor growth and angiogenesis by enhancing extracellular matrix degradation in tumor cell microenvironments, overview
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-
?
additional information
?
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-
matriptase-1 enhances breast tumor growth and invasion and correlates with poor prognosis for breast cancer patients, while matriptase-2 shows the opposite effects, overview
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-
?
additional information
?
-
matriptase-1 enhances breast tumor growth and invasion and correlates with poor prognosis for breast cancer patients, while matriptase-2 shows the opposite effects, overview
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-
?
additional information
?
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-
matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients, while matriptase-1 shows the opposite effects, overview
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-
?
additional information
?
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matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients, while matriptase-1 shows the opposite effects, overview
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-
?
additional information
?
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mutation in gene ST14 causes autosomal recessive ichthyosis with hypotrichosis syndrome, characterized by congenital ichthyosis associated with abnormal hair, overview
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-
?
additional information
?
-
-
physiological functions, overview, MT-SP1 is a type II transmembrane serine protease implicated in a range of cancers including those of the breast, cervix, ovaries, prostate, colon and gastrointestinal tract, MT-SP1 plays a role in embryologic development
-
-
?
additional information
?
-
-
physiological regulatory mechanisms, overview, matriptase is involved in cancer invasion and metastasis by serving as a membrane activator directly on cancer cell surfaces to recruit and activate urokinase type plasminogen activator, MMP-3, hepatocyte growth factor, and insulin-like growth factor binding protein-related protein-1, all of which are important in various aspects of cancers, including extracellular matrix degradation, adhesion, cellular motility and tumor vascularization
-
-
?
additional information
?
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-
reduced matriptase activity is associated with incomplete terminal differentiation of epidermis, epidermal appendages, oral epithelium, and, likely, other epithelial structures, matriptase activity must be tightly controlled in epithelial tissues by transcriptional and posttranslational mechanisms, as matriptase dysregulation can cause embryonic demise as well as malignant transformation
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-
?
additional information
?
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-
the G827R mutation in patients with autosomal recessive ichthyosis with hypotrichosis leads to the expression of an inactive protease
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-
?
additional information
?
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-
matriptase does not cleave acid-sensing ion channel 2
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-
?
additional information
?
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the P1 residue for MT-SP1 substrates is either arginine or lysine
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-
?
additional information
?
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the optimized peptide substrate sequence is Ile-Arg-Ala-Arg-Ser-Ala-Gly
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-
?
additional information
?
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the optimized peptide substrate sequence is Ile-Arg-Ala-Arg-Ser-Ala-Gly
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-
?
additional information
?
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component of the profilaggrin-processing pathway and a key regulator of terminal epidermal differentiation, involved in lipid matrix formation, cornified envelope morphogenesis and stratum corneum desquamation
-
?
additional information
?
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-
a matriptase-prostasin zymogen activation cascade may be functionally operative in multiple epithelial tissues, but matriptase promotes epithelial carcinogenesis independent of prostasin, overview
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-
?
additional information
?
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-
enzyme regulation and deregulation in cancer, overview, matriptase is involved in cancer initiation and progression, it not only facilitates cellular invasiveness but may also activate oncogenic pathways, the protease is essential for postnatal survival, matriptase has pleiotropic functions in the development of the epidermis, hair follicles, and cellular immune system, the protease is essential for postnatal survival, overview
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-
?
additional information
?
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matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development, mechanism, overview
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-
?
additional information
?
-
-
matriptase is a type II transmembrane serine protease, that is up-regulated in a variety of cancers and correlates closely with disease progression, it acts as initiator of protease cascades/signaling pathways, overview
-
-
?
additional information
?
-
-
matriptase, a type II transmembrane serine protease, and prostasin, a glycosylphosphatidylinositol-anchored membrane serine protease, are both required for processing of the epidermis-specific polyprotein, profilaggrin, stratum corneum formation, and acquisition of epidermal barrier function, matriptase, an autoactivating protease, acts upstream from prostasin to initiate a zymogen cascade that is essential for epidermal differentiation, overview
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-
?
additional information
?
-
-
physiological functions, overview, MT-SP1 is critical for proper epidermal development and postnatal survival, MT-SP1 plays a role in embryologic development
-
-
?
additional information
?
-
-
reduced matriptase activity is associated with incomplete terminal differentiation of epidermis, epidermal appendages, oral epithelium, and, likely, other epithelial structures, matriptase activity must be tightly controlled in epithelial tissues by transcriptional and posttranslational mechanisms, as matriptase dysregulation can cause embryonic demise as well as malignant transformation, spatial dysregulation of matriptase leads to the activation of the PI3K-Akt signaling pathway, and dysregulated matriptase synergizes strongly with activated ras to promote epithelial carcinogenesis
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-
?
