Reference on EC 3.4.21.109 - matriptase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sun, J.; Pons, J.; Craik, C.S.
Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies
Biochemistry
42
892-900
2003
Homo sapiens
Benaud, C.; Dickson, R.B.; Lin, C.Y.
Regulation of the activity of matriptase on epithelial cell surfaces by a blood-derived factor
Eur. J. Biochem.
268
1439-1447
2001
Homo sapiens (Q9Y5Y6), Homo sapiens
Lin, C.Y.; Anders, J.; Johnson, M.; Sang, Q.A.; Dickson, R.B.
Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity
J. Biol. Chem.
274
18231-18236
1999
Homo sapiens (Q9Y5Y6), Homo sapiens
Lin, C.Y.; Anders, J.; Johnson, M.; Dickson, R.B.
Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk
J. Biol. Chem.
274
18237-18242
1999
Homo sapiens
Takeuchi, T.; Harris, J.L.; Huang, W.; Yan, K.W.; Coughlin, S.R.; Craik, C.S.
Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates
J. Biol. Chem.
275
26333-26342
2000
Homo sapiens
Lee, S.L.; Dickson, R.B.; Lin, C.Y.
Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease
J. Biol. Chem.
275
36720-36725
2000
Homo sapiens (Q9Y5Y6), Homo sapiens
Benaud, C.; Oberst, M.; Hobson, J.P.; Spiegel, S.; Dickson, R.B.; Lin, C.Y.
Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase
J. Biol. Chem.
277
10539-10546
2002
Homo sapiens
Friedrich, R.; Fuentes-Prior, P.; Ong, E.; Coombs, G.; Hunter, M.; Oehler, R.; Pierson, D.; Gonzalez, R.; Huber, R.; Bode, W.; Madison, E.L.
Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase
J. Biol. Chem.
277
2160-2168
2002
Homo sapiens
Oberst, M.D.; Williams, C.A.; Dickson, R.B.; Johnson, M.D.; Lin, C.Y.
The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor
J. Biol. Chem.
278
26773-26779
2003
Homo sapiens
List, K.; Szabo, R.; Wertz, P.W.; Segre, J.; Haudenschild, C.C.; Kim, S.Y.; Bugge, T.H.
Loss of proteolytically processed filaggrin caused by epidermal deletion of matriptase/MT-SP1
J. Cell. Biol.
163
901-910
2003
Mus musculus
Enyedy, I.J.; Lee, S.L.; Kuo, A.H.; Dickson, R.B.; Lin, C.Y.; Wang, S.
Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase
J. Med. Chem.
44
1349-1355
2001
Homo sapiens (Q9Y5Y6)
Szabo, R.; Netzel-Arnett, S.; Hobson, J.P.; Antalis, T.M.; Bugge, T.H.
Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity
Biochem. J.
290
231-242
2005
Homo sapiens, Mus musculus
-
Oberst, M.D.; Chen, L.L.; Kiyomiya, K.; Williams, C.A.; Lee, M.; Johnson, M.D.; Dickson, R.B.; Lin, C.
HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease
Am. J. Physiol.
289
C462-C470
2005
Homo sapiens
Tsuzuki, S.; Murai, N.; Miyake, Y.; Inouye, K.; Hirayasu, H.; Iwanaga, T.; Fushiki, T.
Evidence for the occurrence of membrane-type serine protease 1/matriptase on the basolateral sides of enterocytes
Biochem. J.
388
679-687
2005
Rattus norvegicus
Ahmed, S.; Jin, X.; Yagi, M.; Yasuda, C.; Sato, Y.; Higashi, S.; Lin, C.Y.; Dickson, R.B.; Miyazaki, K.
Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25)
FEBS J.
273
615-627
2006
Homo sapiens
Desilets, A.; Longpre, J.M.; Beaulieu, M.E.; Leduc, R.
Inhibition of human matriptase by eglin c variants
FEBS Lett.
580
2227-2232
2006
Homo sapiens
Ihara, S.; Miyoshi, E.; Nakahara, S.; Sakiyama, H.; Ihara, H.; Akinaga, A.; Honke, K.; Dickson, R.B.; Lin, C.; Taniguchi, N.
Addition of beta1-6 GlcNAc branching to the oligosaccharide attached to Asn 772 in the serine protease domain of matriptase plays a pivotal role in its stability and resistance against trypsin
Glycobiology
14
139-146
2004
Homo sapiens
Ito, Y.; Akinaga, A.; Yamanaka, K.; Nakagawa, T.; Kondo, A.; Dickson, R.B.; Lin, C.Y.; Miyauchi, A.; Taniguchi, N.; Miyoshi, E.
Co-expression of matriptase and N-acetylglucosaminyltransferase V in thyroid cancer tissues - its possible role in prolonged stability in vivo by aberrant glycosylation
Glycobiology
16
368-374
2006
Homo sapiens
Suzuki, M.; Kobayashi, H.; Kanayama, N.; Saga, Y.; Suzuki, M.; Lin, C.Y.; Dickson, R.B.; Terao, T.
Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase
J. Biol. Chem.
279
14899-14908
2004
Homo sapiens
Jin, X.; Hirosaki, T.; Lin, C.Y.; Dickson, R.B.; Higashi, S.; Kitamura, H.; Miyazaki, K.
Production of soluble matriptase by human cancer cell lines and cell surface activation of its zymogen by trypsin
J. Cell. Biochem.
95
632-647
2005
Homo sapiens
Zeng, L.; Cao, J.; Zhang, X.
Expression of serine protease SNC19/matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 in normal and malignant tissues of gastrointestinal tract
World J. Gastroenterol.
11
6202-6207
2005
Homo sapiens
Netzel-Arnett, S.; Currie, B.M.; Szabo, R.; Lin, C.Y.; Chen, L.M.; Chai, K.X.; Antalis, T.M.; Bugge, T.H.; List, K.
Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation
J. Biol. Chem.
281
32941-32945
2006
Mus musculus
List, K.; Hobson, J.P.; Molinolo, A.; Bugge, T.H.
Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase
J. Cell. Physiol.
213
237-245
2007
Mus musculus
Basel-Vanagaite, L.; Attia, R.; Ishida-Yamamoto, A.; Rainshtein, L.; Ben Amitai, D.; Lurie, R.; Pasmanik-Chor, M.; Indelman, M.; Zvulunov, A.; Saban, S.; Magal, N.; Sprecher, E.; Shohat, M.
Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase
Am. J. Hum. Genet.
80
467-477
2007
Homo sapiens (Q9Y5Y6)
Lee, M.; Tseng, I.; Wang, Y.; Kiyomiya, K.; Johnson, M.D.; Dickson, R.B.; Lin, C.
Autoactivation of matriptase in vitro: requirement for biomembrane and LDL receptor domain
Am. J. Physiol. Cell Physiol.
293
C95-C105
2007
Homo sapiens
Qiu, D.; Owen, K.; Gray, K.; Bass, R.; Ellis, V.
Roles and regulation of membrane-associated serine proteases
Biochem. Soc. Trans.
35
583-587
2007
Homo sapiens, Mus musculus
Chen, M.; Chen, L.M.; Lin, C.Y.; Chai, K.X.
The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase-Prostasin serine protease cascade in cultured epithelial cells
Biochim. Biophys. Acta
1783
896-903
2007
Homo sapiens
Jin, X.; Yagi, M.; Akiyama, N.; Hirosaki, T.; Higashi, S.; Lin, C.Y.; Dickson, R.B.; Kitamura, H.; Miyazaki, K.
Matriptase activates stromelysin (MMP-3) and promotes tumor growth and angiogenesis
Cancer Sci.
97
1327-1334
2006
Homo sapiens
Uhland, K.
Matriptase and its putative role in cancer
Cell. Mol. Life Sci.
63
2968-2978
2006
Homo sapiens, Mus musculus
Parr, C.; Sanders, A.J.; Davies, G.; Martin, T.; Lane, J.; Mason, M.D.; Mansel, R.E.; Jiang, W.G.
Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients
Clin. Cancer Res.
13
3568-3576
2007
Homo sapiens, Homo sapiens (Q9Y5Y6)
Carney, T.J.; von der Hardt, S.; Sonntag, C.; Amsterdam, A.; Topczewski, J.; Hopkins, N.; Hammerschmidt, M.
Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis
Development
134
3461-3471
2007
Danio rerio
Cheng, M.F.; Jin, J.S.; Wu, H.W.; Chiang, P.C.; Sheu, L.F.; Lee, H.S.
Matriptase expression in the normal and neoplastic mast cells
Eur. J. Dermatol.
17
375-380
2007
Homo sapiens
Bugge, T.H.; List, K.; Szabo, R.
Matriptase-dependent cell surface proteolysis in epithelial development and pathogenesis
Front. Biosci.
12
5060-5070
2007
Homo sapiens, Mus musculus
Darragh, M.R.; Bhatt, A.S.; Craik, C.S.
MT-SP1 proteolysis and regulation of cell-microenvironment interactions
Front. Biosci.
13
528-539
2008
Homo sapiens, Mus musculus
Ramsay, A.J.; Reid, J.C.; Velasco, G.; Quigley, J.P.; Hooper, J.D.
The type II transmembrane serine protease matriptase-2 - identification, structural features, enzymology, expression pattern and potential roles
Front. Biosci.
13
569-579
2008
Bos taurus, Canis lupus familiaris, Homo sapiens, Macaca mulatta, Rattus norvegicus, Mus musculus (Q9DBI0)
Lin, C.Y.; Tseng, I.C.; Chou, F.P.; Su, S.F.; Chen, Y.W.; Johnson, M.D.; Dickson, R.B.
Zymogen activation, inhibition, and ectodomain shedding of matriptase
Front. Biosci.
13
621-635
2008
Homo sapiens
Jin, J.S.; Cheng, T.F.; Tsai, W.C.; Sheu, L.F.; Chiang, H.; Yu, C.P.
Expression of the serine protease, matriptase, in breast ductal carcinoma of Chinese women: correlation with clinicopathological parameters
Histol. Histopathol.
22
305-309
2007
Homo sapiens
Desilets, A.; Beliveau, F.; Vandal, G.; McDuff, F.O.; Lavigne, P.; Leduc, R.
Mutation G827R in matriptase causing autosomal recessive Ichthyosis with hypotrichosis yields an inactive protease
J. Biol. Chem.
283
10535-10542
2008
Homo sapiens
Steinmetzer, T.; Schweinitz, A.; Stuerzebecher, A.; Doennecke, D.; Uhland, K.; Schuster, O.; Steinmetzer, P.; Mueller, F.; Friedrich, R.; Than, M.E.; Bode, W.; Stuerzebecher, J.
Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase
J. Med. Chem.
49
4116-4126
2006
Homo sapiens (Q9Y5Y6)
Li, P.; Jiang, S.; Lee, S.L.; Lin, C.Y.; Johnson, M.D.; Dickson, R.B.; Michejda, C.J.; Roller, P.P.
Design and synthesis of novel and potent inhibitors of the type II transmembrane serine protease, matriptase, based upon the sunflower trypsin inhibitor-1
J. Med. Chem.
50
5976-5983
2007
Homo sapiens
Farady, C.J.; Sun, J.; Darragh, M.R.; Miller, S.M.; Craik, C.S.
The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1)
J. Mol. Biol.
369
1041-1051
2007
Homo sapiens
List, K.; Bugge, T.H.; Szabo, R.
Matriptase: potent proteolysis on the cell surface
Mol. Med.
12
1-7
2006
Homo sapiens
Szabo, R.; Molinolo, A.; List, K.; Bugge, T.H.
Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development
Oncogene
26
1546-1556
2007
Mus musculus
Jiang, S.; Li, P.; Lee, S.L.; Lin, C.Y.; Long, Y.Q.; Johnson, M.D.; Dickson, R.B.; Roller, P.P.
Design and synthesis of redox stable analogues of sunflower trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of matriptase
Org. Lett.
9
9-12
2007
Homo sapiens
Tsui, K.H.; Chang, P.L.; Feng, T.H.; Chung, L.C.; Sung, H.C.; Juang, H.H.
Evaluating the function of matriptase and N-acetylglucosaminyltransferase V in prostate cancer metastasis
Anticancer Res.
28
1993-1999
2008
Homo sapiens
Tseng, I.C.; Chou, F.P.; Su, S.F.; Oberst, M.; Madayiputhiya, N.; Lee, M.S.; Wang, J.K.; Sloane, D.E.; Johnson, M.; Lin, C.Y.
Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1
Am. J. Physiol. Cell Physiol.
295
C423-C431
2008
Homo sapiens (Q9Y5Y6), Homo sapiens
Janciauskiene, S.; Nita, I.; Subramaniyam, D.; Li, Q.; Lancaster, J.R.; Matalon, S.
Alpha1-antitrypsin inhibits the activity of the matriptase catalytic domain in vitro
Am. J. Respir. Cell Mol. Biol.
39
631-637
2008
Homo sapiens
Schweinitz, A.; Doennecke, D.; Ludwig, A.; Steinmetzer, P.; Schulze, A.; Kotthaus, J.; Wein, S.; Clement, B.; Steinmetzer, T.
Incorporation of neutral C-terminal residues in 3-amidinophenylalanine-derived matriptase inhibitors
Bioorg. Med. Chem. Lett.
19
1960-1965
2009
Homo sapiens
Steinmetzer, T.; Doennecke, D.; Korsonewski, M.; Neuwirth, C.; Steinmetzer, P.; Schulze, A.; Saupe, S.M.; Schweinitz, A.
Modification of the N-terminal sulfonyl residue in 3-amidinophenylalanine-based matriptase inhibitors
Bioorg. Med. Chem. Lett.
19
67-73
2009
Homo sapiens (Q9Y5Y6)
Kojima, K.; Tsuzuki, S.; Fushiki, T.; Inouye, K.
The activity of a type II transmembrane serine protease, matriptase, is dependent solely on the catalytic domain
Biosci. Biotechnol. Biochem.
73
454-456
2009
Rattus norvegicus
Folgueras, A.R.; de Lara, F.M.; Pendas, A.M.; Garabaya, C.; Rodriguez, F.; Astudillo, A.; Bernal, T.; Cabanillas, R.; Lopez-Otin, C.; Velasco, G.
Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis
Blood
112
2539-2545
2008
Mus musculus
Silvestri, L.; Pagani, A.; Nai, A.; De Domenico, I.; Kaplan, J.; Camaschella, C.
The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin
Cell Metab.
8
502-511
2008
Homo sapiens, Mus musculus
Beliveau, F.; Desilets, A.; Leduc, R.
Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides
FEBS J.
276
2213-2226
2009
Homo sapiens
List, K.
Matriptase: a culprit in cancer?
Future Oncol.
5
97-104
2009
Homo sapiens, Mus musculus
Kojima, K.; Tsuzuki, S.; Fushiki, T.; Inouye, K.
Role of the stem domain of matriptase in the interaction with its physiological inhibitor, hepatocyte growth factor activator inhibitor type I
J. Biochem.
145
783-790
2009
Rattus norvegicus
Szabo, R.; Hobson, J.P.; List, K.; Molinolo, A.; Lin, C.Y.; Bugge, T.H.
Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity
J. Biol. Chem.
283
29495-29504
2008
Homo sapiens, Mus musculus
Sanders, A.J.; Parr, C.; Martin, T.A.; Lane, J.; Mason, M.D.; Jiang, W.G.
Genetic upregulation of matriptase-2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation
J. Cell. Physiol.
216
780-789
2008
Homo sapiens
Lee, P.
Role of matriptase-2 (TMPRSS6) in iron metabolism
Acta Haematol.
122
87-96
2009
Mus musculus, Homo sapiens (Q8IU80)
Szabo, R.; Kosa, P.; List, K.; Bugge, T.H.
Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality
Am. J. Pathol.
174
2015-2022
2009
Mus musculus
Wang, J.; Lee, M.; Tseng, I.; Chou, F.; Chen, Y.; Fulton, A.; Lee, H.; Chen, G.; Johnson, M.; Lin, C.
Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition
Am. J. Physiol. Cell Physiol.
297
459-470
2009
Homo sapiens
Milner, J.M.; Patel, A.; Davidson, R.K.; Swingler, T.E.; Desilets, A.; Young, D.A.; Kelso, E.B.; Donell, S.T.; Cawston, T.E.; Clark, I.M.; Ferrell, W.R.; Plevin, R.; Lockhart, J.C.; Leduc, R.; Rowan, A.D.
Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis
Arthritis Rheum.
62
1955-1966
2010
Homo sapiens
Owen, K.A.; Qiu, D.; Alves, J.; Schumacher, A.M.; Kilpatrick, L.M.; Li, J.; Harris, J.L.; Ellis, V.
Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA
Biochem. J.
426
219-228
2010
Homo sapiens
Miyake, Y.; Tsuzuki, S.; Mochida, S.; Fushiki, T.; Inouye, K.
The role of asparagine-linked glycosylation site on the catalytic domain of matriptase in its zymogen activation
Biochim. Biophys. Acta
1804
156-165
2010
Rattus norvegicus
Tsuzuki, S.; Miyake, Y.; Inouye, K.; Fushiki, T.
The occurrence of matriptase C-terminal fragments on the apical and basolateral sides of Madin-Darby canine kidney epithelial cells
Biosci. Biotechnol. Biochem.
73
2538-2540
2009
Rattus norvegicus
Tsuzuki, S.; Murai, N.; Miyake, Y.; Inouye, K.; Fushiki, T.
The structural requirements of matriptase in its ectodomain release in polarized epithelial cells
Biosci. Biotechnol. Biochem.
74
1295-1297
2010
Rattus norvegicus
Miyake, Y.; Tsuzuki, S.; Fushiki, T.; Inouye, K.
Matriptase does not require hepatocyte growth factor activator inhibitor type-1 for activation in an epithelial cell expression model
Biosci. Biotechnol. Biochem.
74
848-850
2010
Rattus norvegicus
Truksa, J.; Gelbart, T.; Peng, H.; Beutler, E.; Beutler, B.; Lee, P.
Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6
Br. J. Haematol.
147
571-581
2009
Mus musculus
Murai, N.; Miyake, Y.; Tsuzuki, S.; Inouye, K.; Fushiki, T.
Involvement of the cytoplasmic juxtamembrane region of matriptase in its exclusive localization to the basolateral membrane domain of Madin-Darby canine kidney epithelial cells
Cytotechnology
59
169-176
2009
Rattus norvegicus
Miyake, Y.; Tsuzuki, S.; Yasumoto, M.; Fushiki, T.; Inouye, K.
Requirement of the activity of hepatocyte growth factor activator inhibitor type 1 for the extracellular appearance of a transmembrane serine protease matriptase in monkey kidney COS-1 cells
Cytotechnology
60
95-103
2009
Rattus norvegicus
-
Mochida, S.; Tsuzuki, S.; Yasumoto, M.; Inouye, K.; Fushiki, T.
Secreted expression of pseudozymogen forms of recombinant matriptase in Pichia pastoris
Enzyme Microb. Technol.
45
288-294
2009
Rattus norvegicus
-
Ramsay, A.J.; Quesada, V.; Sanchez, M.; Garabaya, C.; Sarda, M.P.; Baiget, M.; Remacha, A.; Velasco, G.; Lopez-Otin, C.
Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms
Hum. Mol. Genet.
18
3673-3683
2009
Homo sapiens
Napp, J.; Dullin, C.; Mueller, F.; Uhland, K.; Petri, J.B.; van de Locht, A.; Steinmetzer, T.; Alves, F.
Time-domain in vivo near infrared fluorescence imaging for evaluation of matriptase as a potential target for the development of novel, inhibitor-based tumour therapies
Int. J. Cancer
127
1958-1974
2010
Homo sapiens
Uhland, K.; Siphos, B.; Arkona, C.; Schuster, M.; Petri, B.; Steinmetzer, P.; Mueller, F.; Schweinitz, A.; Steinmetzer, T.; Van De Locht, A.
Use of IHC and newly designed matriptase inhibitors to elucidate the role of matriptase in pancreatic ductal adenocarcinoma
Int. J. Oncol.
35
347-357
2009
Homo sapiens
Miyake, Y.; Yasumoto, M.; Tsuzuki, S.; Fushiki, T.; Inouye, K.
Activation of a membrane-bound serine protease matriptase on the cell surface
J. Biochem.
146
273-282
2009
Rattus norvegicus
Inouye, K.; Yasumoto, M.; Tsuzuki, S.; Mochida, S.; Fushiki, T.
The optimal activity of a pseudozymogen form of recombinant matriptase under the mildly acidic pH and low ionic strength conditions
J. Biochem.
147
485-492
2010
Rattus norvegicus
Tseng, I.C.; Xu, H.; Chou, F.P.; Li, G.; Vazzano, A.P.; Kao, J.P.; Johnson, M.D.; Lin, C.Y.
Matriptase activation, an early cellular response to acidosis
J. Biol. Chem.
285
3261-3270
2010
Homo sapiens
Bocheva, G.; Rattenholl, A.; Kempkes, C.; Goerge, T.; Lin, C.Y.; DAndrea, M.R.; Staender, S.; Steinhoff, M.
Role of matriptase and proteinase-activated receptor-2 in nonmelanoma skin cancer
J. Invest. Dermatol.
129
1816-1823
2009
Homo sapiens
Lee, S.L.; Huang, P.Y.; Roller, P.; Cho, E.G.; Park, D.; Dickson, R.B.
Matriptase/epithin participates in mammary epithelial cell growth and morphogenesis through HGF activation
Mech. Dev.
127
82-95
2010
Mus musculus
Ganesan, R.; Eigenbrot, C.; Kirchhofer, D.
Structural and mechanistic insight into how antibodies inhibit serine proteases
Biochem. J.
430
179-189
2010
Homo sapiens
Clark, E.B.; Jovov, B.; Rooj, A.K.; Fuller, C.M.; Benos, D.J.
Proteolytic cleavage of human acid-sensing ion channel 1 by the serine protease matriptase
J. Biol. Chem.
285
27130-27143
2010
Homo sapiens
Beliveau, F.; Brule, C.; Desilets, A.; Zimmerman, B.; Laporte, S.A.; Lavoie, C.L.; Leduc, R.
Essential role of endocytosis of the type II transmembrane serine protease TMPRSS6 in regulating its functionality
J. Biol. Chem.
286
29035-29043
2011
Homo sapiens
Bergum, C.; Zoratti, G.; Boerner, J.; List, K.
Strong expression association between matriptase and its substrate prostasin in breast cancer
J. Cell. Physiol.
227
1604-1609
2012
Homo sapiens, Homo sapiens (Q9Y5Y6)
Sisay, M.T.; Steinmetzer, T.; Stirnberg, M.; Maurer, E.; Hammami, M.; Bajorath, J.; Guetschow, M.
Identification of the first low-molecular-weight inhibitors of matriptase-2
J. Med. Chem.
53
5523-5535
2010
Homo sapiens
Sales, K.U.; Masedunskas, A.; Bey, A.L.; Rasmussen, A.L.; Weigert, R.; List, K.; Szabo, R.; Overbeek, P.A.; Bugge, T.H.
Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome
Nat. Genet.
42
676-683
2010
Mus musculus
Colombo, E.; Dsilets, A.; Duchne, D.; Chagnon, F.; Najmanovich, R.; Leduc, R.; Marsault E.
Design and synthesis of potent, selective inhibitors of matriptase
ACS Med. Chem. Lett.
3
530-534
2012
Homo sapiens (Q8IU80)
Wysocka, M.; Gruba, N.; Miecznikowska, A.; Popow-Stellmaszyk, J.; Guetschow, M.; Stirnberg, M.; Furtmann, N.; Bajorath, J.; Lesner, A.; Rolka, K.
Substrate specificity of human matriptase-2
Biochimie
97
121-127
2014
Homo sapiens (Q8IU80), Homo sapiens
Stirnberg, M.; Maurer, E.; Arenz, K.; Babler, A.; Jahnen-Dechent, W.; Guetschow, M.
Cell surface serine protease matriptase-2 suppresses fetuin-A/AHSG-mediated induction of hepcidin
Biol. Chem.
396
81-93
2015
Homo sapiens (Q8IU80)
Goswami, R.; Wohlfahrt, G.; Mukherjee, S.; Ghadiyaram, C.; Nagaraj, J.; Satyam, L.K.; Subbarao, K.; Gopinath, S.; Krishnamurthy, N.R.; Subramanya, H.S.; Ramachandra, M.
Discovery of O-(3-carbamimidoylphenyl)-l-serine amides as matriptase inhibitors using a fragment-linking approach
Bioorg. Med. Chem. Lett.
25
616-620
2015
Homo sapiens (Q9Y5Y6)
Goswami, R.; Mukherjee, S.; Ghadiyaram, C.; Wohlfahrt, G.; Sistla, R.K.; Nagaraj, J.; Satyam, L.K.; Subbarao, K.; Palakurthy, R.K.; Gopinath, S.; Krishnamurthy, N.R.; Ikonen, T.; Moilanen, A.; Subramanya, H.S.; Kallio, P.; Ramachandra, M.
Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy
Bioorg. Med. Chem.
22
3187-3203
2014
Homo sapiens (Q9Y5Y6), Homo sapiens
Miller, G.S.; List, K.
The matriptase-prostasin proteolytic cascade in epithelial development and pathology
Cell Tissue Res.
351
245-253
2013
Mus musculus
Maurer, E.; Sisay, M.; Stirnberg, M.; Steinmetzer, T.; Bajorath, J.; Guetschow, M.
Insights into matriptase-2 substrate binding and inhibition mechanisms by analyzing active-site-mutated variants
ChemMedChem
7
68-72
2012
Homo sapiens (Q8IU80), Homo sapiens (Q9Y5Y6)
Buzza, M.S.; Martin, E.W.; Driesbaugh, K.H.; Desilets, A.; Leduc, R.; Antalis, T.M.
Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway
J. Biol. Chem.
288
10328-10337
2013
Homo sapiens
Quimbar, P.; Malik, U.; Sommerhoff, C.P.; Kaas, Q.; Chan, L.Y.; Huang, Y.H.; Grundhuber, M.; Dunse, K.; Craik, D.J.; Anderson, M.A.; Daly, N.L.
High-affinity cyclic peptide matriptase inhibitors
J. Biol. Chem.
288
13885-13896
2013
Homo sapiens (Q9Y5Y6)
Zhao, N.; Nizzi, C.P.; Anderson, S.A.; Wang, J.; Ueno, A.; Tsukamoto, H.; Eisenstein, R.S.; Enns, C.A.; Zhang, A.S.
Low intracellular iron increases the stability of matriptase-2
J. Biol. Chem.
290
4432-4446
2015
Homo sapiens (Q8IU80)
Duchene, D.; Colombo, E.; Desilets, A.; Boudreault, P.L.; Leduc, R.; Marsault, E.; Najmanovich, R.
Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2
J. Med. Chem.
57
10198-10204
2014
Homo sapiens (Q8IU80)
Hamilton, B.S.; Gludish, D.W.; Whittaker, G.R.
Cleavage activation of the human-adapted influenza virus subtypes by matriptase reveals both subtype and strain specificities
J. Virol.
86
10579-10586
2012
Homo sapiens (Q9Y5Y6)
Beaulieu, A.; Gravel, E.; Cloutier, A.; Marois, I.; Colombo, E.; Desilets, A.; Verreault, C.; Leduc, R.; Marsault, E.; Richter, M.V.
Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium
J. Virol.
87
4237-4251
2013
Homo sapiens (Q9Y5Y6), Homo sapiens
Chai, A.C.; Robinson, A.L.; Chai, K.X.; Chen, L.M.
Ibuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase
BMC Cancer
15
1025
2015
Homo sapiens
Chen, L.M.; Chai, K.X.
Matriptase cleaves the amyloid-beta peptide 1-42 at Arg-5, Lys-16, and Lys-28
BMC Res. Notes
12
005
2019
Homo sapiens
Buzza, M.S.; Johnson, T.A.; Conway, G.D.; Martin, E.W.; Mukhopadhyay, S.; Shea-Donohue, T.; Antalis, T.M.
Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis
J. Biol. Chem.
292
10801-10812
2017
Mus musculus
Tamberg, T.; Hong, Z.; De Schepper, D.; Skovbjerg, S.; Dupont, D.M.; Vitved, L.; Schar, C.R.; Skjoedt, K.; Vogel, L.K.; Jensen, J.K.
Blocking the proteolytic activity of zymogen matriptase with antibody-based inhibitors
J. Biol. Chem.
294
314-326
2019
Homo sapiens (Q9Y5Y6), Homo sapiens
Wu, C.J.; Feng, X.; Lu, M.; Morimura, S.; Udey, M.C.
Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis
J. Clin. Invest.
127
623-634
2017
Homo sapiens
Paszti-Gere, E.; Barna, R.F.; Ujhelyi, G.; Steinmetzer, T.
Interaction exists between matriptase inhibitors and intestinal epithelial cells
J. Enzyme Inhib. Med. Chem.
31
736-741
2016
Sus scrofa (F1S6D6), Sus scrofa
Maiwald, A.; Hammami, M.; Wagner, S.; Heine, A.; Klebe, G.; Steinmetzer, T.
Changing the selectivity profile - from substrate analog inhibitors of thrombin and factor Xa to potent matriptase inhibitors
J. Enzyme Inhib. Med. Chem.
31
89-97
2016
Homo sapiens (Q9Y5Y6)
Damalanka, V.C.; Han, Z.; Karmakar, P.; ODonoghue, A.J.; La Greca, F.; Kim, T.; Pant, S.M.; Helander, J.; Klefstroem, J.; Craik, C.S.; Janetka, J.W.
Discovery of selective matriptase and hepsin serine protease inhibitors useful chemical tools for cancer cell biology
J. Med. Chem.
62
480-490
2019
Homo sapiens (Q9Y5Y6)
Drees, L.; Koenigsmann, T.; Jaspers, M.H.J.; Pflanz, R.; Riedel, D.; Schuh, R.
Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis
PLoS Genet.
15
e1007882
2019
Drosophila melanogaster (A1Z7M3)
Lai, Y.J.; Chang, H.H.; Lai, H.; Xu, Y.; Shiao, F.; Huang, N.; Li, L.; Lee, M.S.; Johnson, M.D.; Wang, J.K.; Lin, C.Y.
N-Glycan branching affects the subcellular distribution of and inhibition of matriptase by HAI-2/placental bikunin
PLoS ONE
10
e0132163
2015
Homo sapiens
Lee, S.P.; Kao, C.Y.; Chang, S.C.; Chiu, Y.L.; Chen, Y.J.; Chen, M.G.; Chang, C.C.; Lin, Y.W.; Chiang, C.P.; Wang, J.K.; Lin, C.Y.; Johnson, M.D.
Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin
PLoS ONE
13
e0192632
2018
Homo sapiens
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