3.4.21.109: matriptase

This is an abbreviated version!
For detailed information about matriptase, go to the full flat file.

Word Map on EC 3.4.21.109

3.4.21.109

hepatocyte

hepcidin

hai-1

anemia

metastasis

prostate

hepsin

zymogen

transferrin

prostasin

overload

trypsin-like

irida

plasminogen

hemojuvelin

iron-refractory

kunitz-type

inhibitor-1

kunitz

ttsps

hemochromatosis

erythropoiesis

microcytic

membrane-anchored

urokinase-type

ferroportin

iron-deficiency

pro-hgf

pericellular

upa

autoactivation

two-chain

hypochromic

medicine

protease-activated

tmprss4

spint2

corpuscular

erythroferrone

profilaggrin

camostat

corin

epithelial-derived

par-2

hypotrichosis

drug development

diagnostics

Reaction

cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position =

Synonyms

Epi/MTP, epithin, epithin/matriptase, influenza virus-activating protease, matriptase, matriptase-1, matriptase-2, matriptase-3, matriptase1, matriptase1a, membrane-type serine protease 1, membrane-type serine protease 1/matripase, membrane-type serine protease-1, membrane-type serine protease1, membrane-type serine proteinase matripase, membrane-type serine proteinase matriptase, More, MT-2, MT-SP-1, MT-SP1, MT-SP1/matripase, MT2, notopleural, prostamin, PRSS14, r-matripase, serine protease matriptase-2, serine protease SNC19/matripase, SNC19, ST-14, ST14, suppression of tumorigenecity 14, suppressor of tumorigenicity 14, suppressor of tumorigenicity 14 protein, suppressor of tumorigenicity-14, TADG-15, TADG15, TMPRSS6, transmembrane serine protease 6, tumor-associated differentially expressed gene-15, tumor-associated type II transmembrane serine protease, type 2 transmembrane serine protease, type II transmembrane protease, type II transmembrane serine protease

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.109 matriptase

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Results	in table
32	Activating Compound
340	AA Sequence
23	Application
1	CAS Registry Number
48	Cloned(Commentary)
5	Crystallization (Commentary)
2424	Disease/ Diagnostics
11	Expression
55	General Information
2	General Stability
2	IC50 Value
292	Inhibitors
11	kcat/KM [mM/s]
232	Ki Value [mM]
61	KM Value [mM]
104	Localization
4	Metals/Ions
79	Molecular Weight [Da]
157	Natural Substrates/ Products (Substrates)
125	Organism
23	PDB ID
19	pH Optimum
1	pH Range
42	Posttranslational Modification
95	Protein Variants
23	Purification (Commentary)
9	Reaction
37	Reaction Type
122	Reference
3	Renatured (Commentary)
430	Source Tissue
3	Specific Activity [micromol/min/mg]
322	Substrates and Products (Substrate)
26	Subunits
193	Synonyms
13	Temperature Optimum [°C]
40	Turnover Number [1/s]

Metals Ions

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Metals Ions on EC 3.4.21.109 - matriptase

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Ca2+

2 entries

Na+

Rattus norvegicus

in a buffer containing 5 mM NaCl the activity of a pseudozymogen form of recombinant matriptase (HL-matriptase) is only 30times lower than that of the respective two-chain form (activated form after enterokinase treatment)

708958

additional information

Homo sapiens

Q8IU80

low intracellular iron increases the stability of matriptase-2, overview

732181