3.4.21.106: hepsin

This is an abbreviated version!
For detailed information about hepsin, go to the full flat file.

Reaction

cleavage after basic amino-acid residues, with Arg strongly preferred to Lys =

Synonyms

hepsin, S01.224, TMPRSS1, transmembrane serine protease 1, type II transmembrane serine protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.106 hepsin

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Results	in table
2	Activating Compound
7	AA Sequence
18	Application
1	CAS Registry Number
22	Cloned(Commentary)
5	Crystallization (Commentary)
775	Disease/ Diagnostics
1	Expression
9	General Information
1	IC50 Value
51	Inhibitors
10	Ki Value [mM]
18	KM Value [mM]
20	Localization
1	Metals/Ions
26	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
55	Organism
3	PDB ID
3	pH Optimum
1	pH Range
1	pI Value
4	Posttranslational Modification
6	Protein Variants
14	Purification (Commentary)
1	Reaction
26	Reaction Type
55	Reference
100	Source Tissue
1	Specific Activity [micromol/min/mg]
96	Substrates and Products (Substrate)
7	Subunits
17	Synonyms
2	Temperature Optimum [°C]
16	Turnover Number [1/s]

Expression

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Expression on EC 3.4.21.106 - hepsin

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

hepsin expression correlates with synovitis as well as tumour necrosis factor alpha expression, and is induced in cartilage by a pro-inflammatory stimulus

Homo sapiens

P05981

755460