3.4.21.106: hepsin

This is an abbreviated version!
For detailed information about hepsin, go to the full flat file.

Reaction

cleavage after basic amino-acid residues, with Arg strongly preferred to Lys =

Synonyms

hepsin, S01.224, TMPRSS1, transmembrane serine protease 1, type II transmembrane serine protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.106 hepsin

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Results	in table
2	Activating Compound
7	AA Sequence
18	Application
1	CAS Registry Number
22	Cloned(Commentary)
5	Crystallization (Commentary)
775	Disease/ Diagnostics
1	Expression
9	General Information
1	IC50 Value
51	Inhibitors
10	Ki Value [mM]
18	KM Value [mM]
20	Localization
1	Metals/Ions
26	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
55	Organism
3	PDB ID
3	pH Optimum
1	pH Range
1	pI Value
4	Posttranslational Modification
6	Protein Variants
14	Purification (Commentary)
1	Reaction
26	Reaction Type
55	Reference
100	Source Tissue
1	Specific Activity [micromol/min/mg]
96	Substrates and Products (Substrate)
7	Subunits
17	Synonyms
2	Temperature Optimum [°C]
16	Turnover Number [1/s]

KI Value

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of the Enzyme Summary Page.

KI Value on EC 3.4.21.106 - hepsin

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0001

1-[6-(6-methyl-3H-indol-2-yl)pyridin-2-yl]cyclohexan-1-ol

Homo sapiens

P05981

pH not specified in the publication, temperature not specified in the publication

752981

0.0000017

9-fluorenylmethyloxycarbonyl-NR-ketobenzothiazole

Homo sapiens

P05981

pH not specified in the publication, temperature not specified in the publication

754402

0.00026

HAI-2

Homo sapiens

-

-

687522

-

0.001

hepatocyte growth factor activator inhibitor-1B, hepatocyte growth factor activator inhibitor-2

Homo sapiens

P05981

completely inhibits

673609

-

0.0416

HI-10331

Homo sapiens

-

-

687522

0.000022

N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamido-1-oxopentan-2-yl]-N2-(20-[3,3-dimethyl-5-sulfo-2-[(1E)-3-[(4E)-4-[(2E)-2-(1,3,3-trimethyl-5-sulfo-1,3-dihydro-2H-indol-2-ylidene)ethylidene]cyclohex-1-en-1-yl]prop-1-en-1-yl]-3H-indolium-1-yl]-16-oxo-4,7,10,13-tetraoxa-15-azaicosan-1-oyl)-L-leucinamide

Homo sapiens

P05981

pH not specified in the publication, temperature not specified in the publication

752938

0.000003

N2-acetyl-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamido-1-oxopentan-2-yl]-L-leucinamide

Homo sapiens

P05981

pH not specified in the publication, temperature not specified in the publication

752986

0.000022

N2-acetyl-N-[5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-L-leucinamide

Homo sapiens

P05981

pH not specified in the publication, temperature not specified in the publication

752986

0.00002

PEGylated Kunitz domain-1

Mus musculus

-

apparent value

707989

-