3.4.21.106: hepsin
This is an abbreviated version!
For detailed information about hepsin, go to the full flat file.
Word Map on EC 3.4.21.106
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3.4.21.106
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prostate
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matriptase
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medicine
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hai-1
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prostasin
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trypsin-like
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ttsps
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pro-hgf
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amacr
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tmprss3
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uromodulin
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biotechnology
- 3.4.21.106
- prostate
- matriptase
- medicine
- hai-1
- prostasin
-
trypsin-like
-
ttsps
- pro-hgf
- amacr
-
tmprss3
-
uromodulin
- biotechnology
Reaction
cleavage after basic amino-acid residues, with Arg strongly preferred to Lys =
Synonyms
hepsin, S01.224, TMPRSS1, transmembrane serine protease 1, type II transmembrane serine protease
ECTree
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Crystallization
Crystallization on EC 3.4.21.106 - hepsin
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extracellular portion of hepsin, starting at residue 46 and continuing to the end of the coding region, hanging drop vapor diffusion method
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has scavenger receptor-like cysteine-rich domain and a large loop between residues 241 and 256, which may represent a major determinant for its substrate recognition
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hepsin in complex with antibody hH35, hanging drop vapor diffusion method, using 18% (w/v) PEG 3350, 0.15 M Mg2SO4 and 0.01 M BaCl2
molecular docking of inhibitor. The P1 and P2 binding sites are occupied by the conserved Arg and then the variable second side chain, respectively. The 9-fluorenylmethyloxycarbonyl group forms pi-pi interactions with the conserved Trp in the P4 pocket