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3.4.21.106: hepsin

This is an abbreviated version!
For detailed information about hepsin, go to the full flat file.

Word Map on EC 3.4.21.106

Reaction

cleavage after basic amino-acid residues, with Arg strongly preferred to Lys =

Synonyms

hepsin, S01.224, TMPRSS1, transmembrane serine protease 1, type II transmembrane serine protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.106 hepsin

Crystallization

Crystallization on EC 3.4.21.106 - hepsin

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
by sitting-drop method
-
extracellular portion of hepsin, starting at residue 46 and continuing to the end of the coding region, hanging drop vapor diffusion method
-
has scavenger receptor-like cysteine-rich domain and a large loop between residues 241 and 256, which may represent a major determinant for its substrate recognition
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hepsin in complex with antibody hH35, hanging drop vapor diffusion method, using 18% (w/v) PEG 3350, 0.15 M Mg2SO4 and 0.01 M BaCl2
molecular docking of inhibitor. The P1 and P2 binding sites are occupied by the conserved Arg and then the variable second side chain, respectively. The 9-fluorenylmethyloxycarbonyl group forms pi-pi interactions with the conserved Trp in the P4 pocket