Literature summary for 3.4.21.106 extracted from

Wilkinson, D.J.; Desilets, A.; Lin, H.; Charlton, S.; Del Carmen Arques, M.; Falconer, A.; Bullock, C.; Hsu, Y.C.; Birchall, K.; Hawkins, A.; Thompson, P.; Ferrell, W.R.; Lockhart, J.; Plevin, R.; Zhang, Y.; Blain, E.; Lin, S.W.; Leduc, R.; Milner, J.M.; Rowan, A.D.
The serine proteinase hepsin is an activator of pro-matrix metalloproteinases molecular mechanisms and implications for extracellular matrix turnover (2017), Sci. Rep., 7, 16693 .

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P05981	-	-

Expression

Organism	Comment	Expression
Homo sapiens	hepsin expression correlates with synovitis as well as tumour necrosis factor alpha expression, and is induced in cartilage by a pro-inflammatory stimulus	additional information

General Information

General Information	Comment	Organism
physiological function	addition of hepsin to osteoarthritis cartilage in explant culture induces significant collagen and aggrecan release and activates metalloproteinases proMMP-1 and proMMP-3. Hepsin directly cleaves the aggrecan core protein at a cleavage site within the interglobular domain. Hepsin expression correlates with synovitis as well as tumour necrosis factor alpha expression, and is induced in cartilage by a pro-inflammatory stimulus. Hepsin demonstrates markedly reduced capacity to activate proteinase-activated receptor-2, compared with matriptase	Homo sapiens

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Release 2023.1 (January 2023)