3.4.21.106: hepsin
This is an abbreviated version!
For detailed information about hepsin, go to the full flat file.
Word Map on EC 3.4.21.106
-
3.4.21.106
-
prostate
-
matriptase
-
medicine
-
hai-1
-
prostasin
-
trypsin-like
-
ttsps
-
pro-hgf
-
amacr
-
tmprss3
-
uromodulin
-
biotechnology
- 3.4.21.106
- prostate
- matriptase
- medicine
- hai-1
- prostasin
-
trypsin-like
-
ttsps
- pro-hgf
- amacr
-
tmprss3
-
uromodulin
- biotechnology
Reaction
cleavage after basic amino-acid residues, with Arg strongly preferred to Lys =
Synonyms
hepsin, S01.224, TMPRSS1, transmembrane serine protease 1, type II transmembrane serine protease
ECTree
Advanced search results
Application
Application on EC 3.4.21.106 - hepsin
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
biotechnology
-
the aim of this study is to establish a cell line that directly secrets rFVIIa into cell culture medium: Factor VII and hepsin cDNAs are isolated from HepG2 cell line and cloned into pcDNA3-1 vector. The constructs are co-trasfected to CHO cell line. A cell line that permanently expresses recombinant factor VII (rFVII) and hepsin is established. FVIIa protein is secreted to medium of CHO cells co-transfected with pcNDA3-1-FVII and pcNDA3-1-hepsin. A three- to fourfold decrease in clotting time is observed when human FVII-depleted plasma is used in combination with human thromboplastin in the presence of rFVII, confirming the biological activity of rFVII. A cell line is established expressing FVIIa using genetic engineering methods
medicine
-
expression of the non-transmembrane isoform in vivo does not exert any apparent inhibitory effect on cell growth
medicine
-
hepsin expression in tumours is dysregulated and may influence tumorigenesis through inappropiate activation and/or regulation of hepatocyte growth factor receptor functions
medicine
hepsin is a potent activator of pro-hepatocyte growth factor, thus contributing to tumor progression
medicine
hepsin is significantly decreased in pT2 or greater tumor samples, while expression does not differ between the normal and cancerous tissue of pT1 tumors, survival in patients bearing tumors with hepsin expression below the 10th percentile expression of hepsin in noncancerous tissue is poorer than that in patients with tumors with expression above that cutoff, the level of hepsin is found to be a significant predictor of death from renal cell carcinoma
medicine
-
hepsin significantly inhibits cell growth in the monolayer, anchorage-independent cell growth in soft agar in vitro, and tumorigenicity in vivo in ovarian cancer cell lines, through up-regulation of p53-dependent apoptosis and caspase-3, -6, and -7 activations
medicine
human hepsin interacts directly with X protein of human hepatitis B virus both in vitro and in vivo, their interaction appears to play a role in both promoting cell proliferation and blocking apoptosis in human liver tumor cell and normal liver cell lines, promotes expression of viral protein HBeAg in Hep-G2.2.1.5 cells, thus stimulating viral replication
medicine
-
overexpression of hepsin in a mouse model of nonmetastasizing prostate cancer has no impact on cell proliferation, but causes disorganization of the basement membrane and promotes primary prostate cancer progression and metastasis to liver, lung and bones
medicine
-
association of five of eleven single nucleotide polymorphisms on the hepsin gene HPN with susceptibility to prostate cancer among men of European descent. Association of one of the single nucleotide polymorphisms with Gleason score, which suggests a role of HPN in tumor aggressiveness
medicine
-
hepsin has a potential therapeutic effect that inhibits through upregulation of p53-dependent apoptosis and caspase-3, -6, and -7 activations. Hepsin may be useful in ovarian cancer treatment
medicine
-
hepsin is not necessary for embryonic development of mice and postnatal survival and is dispensable for normal hemostasis and liver function
medicine
-
hepsin is one of the most upregulated genes in prostate cancer. Upregulation appears to correlate with disease progression. Role of hepsin is more important in cancer cell migration/invasion than cell proliferation. Hepsin mRNA expression appears to be lower in hormone-refractory prostate cancer compared to clinically localized prostate cancer. Single nucleotide polymorphisms are associated with prostate cancer susceptibility. In contrast, prostate cancer cell lines stably transfected with a hepsin expressing plasmid grow slower and are less invasive in culture. Similarly, stable transfection of hepsin cDNA in ovarian cancer cell lines promotes apoptosis and inhibits tumor cell growth
medicine
-
hepsin may initiate plasmin-mediated proteolytic pathways at the tumor/stroma interface that lead to basement membrane disruption and tumor progression
medicine
-
hepsin protein expression may be an important indication for high risk of endometrial cancer
medicine
-
direct cleavage of Laminin-332 may be one mechanism by which hepsin promotes prostate tumor progression and metastasis, possibly by up-regulating prostate cancer cell motility
medicine
-
germline genetic variation of HPN does not seem to contribute to risk of prostate cancer or prognosis
medicine
alpha-methylacyl-CoA racemase and hepsin are unable to diagnose prostate cancer with better true positive and false negative rates than prostate-specific antigen. There are no correlations between alpha-methylacyl-CoA racemase levels, hepsin levels, tumor stage of benign prostate hyperplasia and prostate cancer, and Gleason score