3.4.21.100: sedolisin

This is an abbreviated version!
For detailed information about sedolisin, go to the full flat file.

Word Map on EC 3.4.21.100

3.4.21.100

peptidase

proteinases

subtilisins

merops

ceroid

pcp

lipofuscinosis

tripeptidyl-peptidase

diazoacetyl-dl-norleucine

subtilisin-like

prosegment

tripeptidyl

b-chain

1,2-epoxy-3-p-nitrophenoxypropane

coagulans

medicine

Reaction

Hydrolysis of the B chain of insulin at -Glu13-/-Ala-, -Leu15-/-Tyr- and -Phe25-/-Tyr-, and angiotensin I at -Tyr4-/-Ile-. A good synthetic substrate is Lys-Pro-Ile-Glu-Phe-/-Phe(NO2)-Arg-Leu =

Synonyms

EC 3.4.23.37, grifolisin, PCP, Pepstatin-insensitive carboxyl proteinase, PSCP, pseudomonalisin, pseudomonapepsin, Pseudomonas serine-carboxyl proteinase, Pseudomonas sp. pepstatin-insensitive carboxyl proteinase, scytalidolisin, scytalidopepsin A, SedA, SedB, SedC, SedD, sedolisin

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.100 sedolisin

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Results	in table
244	AA Sequence
2	Application
1	CAS Registry Number
2	Cloned(Commentary)
4	Crystallization (Commentary)
1	General Information
26	Inhibitors
7	Ki Value [mM]
57	KM Value [mM]
2	Metals/Ions
10	Molecular Weight [Da]
30	Organism
6	PDB ID
4	pH Optimum
1	pH Range
1	pH Stability
1	pI Value
5	Posttranslational Modification
10	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
21	Reference
5	Source Tissue
2	Specific Activity [micromol/min/mg]
76	Substrates and Products (Substrate)
5	Subunits
27	Synonyms
2	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
77	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.4.21.100 - sedolisin

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Acid-denatured hemoglobin + H2O

?

show the reaction diagram

show

Ala-Ala-Phe-p-nitroanilide + H2O

Ala-Ala-Phe + p-nitroaniline

show the reaction diagram

show

Ala-Pro-Gly-Asp-Arg-Ile-Tyr-Val-His-Pro-Phe + H2O

Arg-Pro-Gly + Asp-Arg-Ile + Tyr-Val-His-Pro-Phe

show the reaction diagram

show

casein + H2O

?

show the reaction diagram

show

Hemoglobin + H2O

?

show the reaction diagram

Grifola frondosa

-

-

-

-

?

Leu-Leu-Glu-Phe-Leu + H2O

Leu-Leu-Glu + Phe-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ala-Asp-Phe-4-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ala-Asp-Phe + 4-nitrophenylalanine-Arg-Leu

show the reaction diagram

show

Lys-Pro-Ala-Glu-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ala-Glu-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ala-Leu-Phe-p-nitrophenylalanine-Arg-Leu + H2O

?

show the reaction diagram

Pseudomonas sp.

-

-

?

Lys-Pro-Ala-Lys-Leu-4-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ala-Lys-Leu + 4-nitrophenylalanine-Arg-Leu

show the reaction diagram

show

Lys-Pro-Ala-Lys-Phe-4-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ala-Lys-Phe + 4-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

-

?

Lys-Pro-Arg-Glu-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Arg-Glu-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Asn-Gln-Phe-4-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Asn-Gln-Phe + 4-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

-

?

Lys-Pro-Asn-Glu-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Asn-Glu-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Asp-Glu-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Asp-Glu-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Gln-Glu-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Gln-Glu-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Glu-Glu-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Glu-Glu-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Ala-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ile-Ala-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Arg-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ile-Arg-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Asn-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ile-Asn-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Asp-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ile-Asp-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Gln-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ile-Gln-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O

Lys-Pro-Ile-Glu-Phe + (4-nitro)Phe-Arg-Leu

show the reaction diagram

show

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Ala-Leu + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Ala-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Arg-Ala + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Arg-Ala

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Arg-Arg + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Arg-Arg

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Arg-Asp + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Arg-Asp

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Arg-Ile + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Arg-Ile

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Arg-Phe + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Arg-Phe

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Arg-Ser + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Arg-Ser

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Arg-Tyr + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Arg-Tyr

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Arg-Val + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Arg-Val

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Asn-Leu + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Asn-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Asp-Leu + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Asp-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Glu-Leu + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Glu-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Ile-Leu + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Ile-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Leu-Leu + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Leu-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Lys-Leu + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Lys-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Ser-Leu + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Ser-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Glu-Phe-p-nitrophenylalanine-Val-Leu + H2O

Lys-Pro-Ile-Glu-Phe + p-nitrophenylalanine-Val-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-His-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ile-His-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Ile-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ile-Ile-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Leu-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ile-Leu-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Lys-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ile-Lys-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Nle-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ile-Nle-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Pro-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ile-Pro-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Ser-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ile-Ser-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Thr-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ile-Thr-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ile-Val-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ile-Val-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Leu-Glu-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Leu-Glu-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Lys-Glu-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Lys-Glu-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Ser-Glu-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Ser-Glu-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Thr-Glu-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Thr-Glu-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Val-Glu-Phe-p-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Val-Glu-Phe + p-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Lys-Pro-Val-Ser-Tyr-4-nitrophenylalanine-Arg-Leu + H2O

Lys-Pro-Val-Ser-Tyr + 4-nitrophenylalanine-Arg-Leu

show the reaction diagram

Pseudomonas sp.

-

-

-

-

?

Mca-Lys-Pro-Pro-Leu-Glu-Tyr-Arg-Leu-Gly-Lys(DNP)-Gly + H2O

Mca-Lys-Pro-Pro-Leu-Glu + Tyr-Arg-Leu-Gly-Lys(DNP)-Gly

show the reaction diagram

Pseudomonas sp.

-

-

-

?

Milk casein + H2O

?

show the reaction diagram

Grifola frondosa

-

-

-

-

?

Oxidized insulin B-chain + H2O

?

show the reaction diagram

Grifola frondosa

-

hydrolysis of four bonds, F1-V2, A14-L15, G20-E21, F24-F25

-

-

?

Phe-Pro-Ala-p-nitroanilide + H2O

Phe-Pro-Ala + p-nitroaniline

show the reaction diagram

show

Ser-Pro-Ala-Lys-Phe-(4-nitro)Phe-Arg-Leu + H2O

Ser-Pro-Ala-Lys-Phe + (4-nitro)Phe-Arg-Leu

show the reaction diagram

show

additional information

?

-

show

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Release 2023.1 (January 2023)