3.4.21.100: sedolisin
This is an abbreviated version!
For detailed information about sedolisin, go to the full flat file.
Word Map on EC 3.4.21.100
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3.4.21.100
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peptidase
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proteinases
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subtilisins
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merops
-
ceroid
-
pcp
-
lipofuscinosis
-
tripeptidyl-peptidase
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diazoacetyl-dl-norleucine
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subtilisin-like
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prosegment
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tripeptidyl
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b-chain
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1,2-epoxy-3-p-nitrophenoxypropane
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coagulans
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medicine
- 3.4.21.100
- peptidase
- proteinases
- subtilisins
- merops
-
ceroid
- pcp
- lipofuscinosis
-
tripeptidyl-peptidase
- diazoacetyl-dl-norleucine
-
subtilisin-like
- prosegment
-
tripeptidyl
- b-chain
-
1,2-epoxy-3-p-nitrophenoxypropane
-
coagulans
- medicine
Reaction
Hydrolysis of the B chain of insulin at -Glu13-/-Ala-, -Leu15-/-Tyr- and -Phe25-/-Tyr-, and angiotensin I at -Tyr4-/-Ile-. A good synthetic substrate is Lys-Pro-Ile-Glu-Phe-/-Phe(NO2)-Arg-Leu =
Synonyms
EC 3.4.23.37, grifolisin, PCP, Pepstatin-insensitive carboxyl proteinase, PSCP, pseudomonalisin, pseudomonapepsin, Pseudomonas serine-carboxyl proteinase, Pseudomonas sp. pepstatin-insensitive carboxyl proteinase, scytalidolisin, scytalidopepsin A, SedA, SedB, SedC, SedD, sedolisin
ECTree
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Reference
Reference on EC 3.4.21.100 - sedolisin
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Oda, K.; Fukuda, Y.; Murao, S.; Uchida, K.; Kainosho, M.
Novel proteinase inhibitor, tyrostatin, inhibiting some pepstatin-insensitive carboxyl proteinases
Agric. Biol. Chem.
53
405-415
1989
Pseudomonas sp., Xanthomonas sp., Pseudomonas sp. No. 101, Xanthomonas sp. No. T-22
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Oda, K.; Sugitani, M.; Fukuhara, K.; Murao, S.
Purification and properties of a pepstatin-insensitive carboxyl proteinase from a gram-negative bacterium
Biochim. Biophys. Acta
923
463-469
1987
Pseudomonas sp., Pseudomonas sp. No. 101
Oda, K.; Nakatani, H.; Dunn, B.M.
Substrate specificity and kinetic properties of pepstatin-insensitive carboxyl proteinase from Pseudomonas sp. No. 101
Biochim. Biophys. Acta
1120
208-214
1992
Pseudomonas sp., Pseudomonas sp. No. 101
Wlodawer, A.; Li, M.; Gustchina, A.; Oyama, H.; Dunn, B.M.; Oda, K.
Structural and enzymatic properties of the sedolisin family of serine-carboxyl peptidases
Acta Biochim. Pol.
50
81-102
2003
Pseudomonas sp.
Wlodawer, A.; Li, M.; Gustchina, A.; Oyama, H.; Oda, K.; Beyer, B.B.; Clemente, J.; Dunn, B.M.
Two inhibitor molecules bound in the active site of Pseudomonas sedolisin: a model for the bi-product complex following cleavage of a peptide substrate
Biochem. Biophys. Res. Commun.
314
638-645
2004
Pseudomonas sp.
Wlodawer, A.; Li, M.; Gustchina, A.; Dauter, Z.; Uchida, K.; Oyama, H.; Goldfarb, N.E.; Dunn, B.M.; Oda, K.
Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase
Biochemistry
40
15602-15611
2001
Pseudomonas sp. (P42790), Pseudomonas sp.
Ito, M.; Narutaki, S.; Uchida, K.; Oda, K.
Identification of carboxyl residues in pepstatin-insensitive carboxyl proteinase from Pseudomonas sp. 101 that participate in catalysis and substrate binding
J. Biochem.
125
210-216
1999
Pseudomonas sp.
Narutaki, S.; Dunn, B.M.; Oda, K.
Subsite preferences of pepstatin-insensitive carboxyl proteinases from bacteria
J. Biochem.
125
75-81
1999
Pseudomonas sp.
Oyama, H.; Abe, S.I.; Ushiyama, S.; Takahashi, S.; Oda, K.
Identification of catalytic residues of pepstatin-insensitive carboxyl proteinases from prokaryotes by site-directed mutagenesis
J. Biol. Chem.
274
27815-27822
1999
Pseudomonas sp. (P42790)
Wlodawer, A.; Li, M.; Dauter, Z.; Gustchina, A.; Uchida, K.; Oyama, H.; Dunn, B.M.; Oda, K.
Carboxyl proteinase from Pseudomonas defines a novel family of subtilisin-like enzymes
Nat. Struct. Biol.
8
442-446
2001
Pseudomonas sp. (P42790), Pseudomonas sp.
Reichard, U.; Lechenne, B.; Asif, A.R.; Streit, F.; Grouzmann, E.; Jousson, O.; Monod, M.
Sedolisins, a new class of secreted proteases from Aspergillus fumigatus with endoprotease or tripeptidyl-peptidase activity at acidic pHs
Appl. Environ. Microbiol.
72
1739-1748
2006
Aspergillus fumigatus, Aspergillus fumigatus NCPF 7367
Suzuki, N.; Nishibori, K.; Oodaira, Y.; Kitamura, S.; Michigami, K.; Nagata, K.; Tatara, Y.; Lee, B.R.; Ichishima, E.
Grifolisin, a member of the sedolisin family produced by the fungus Grifola frondosa
Phytochemistry
66
983-990
2005
Grifola frondosa
Takahashi, K.; Oda, K.
Structural evidence that scytalidolisin (formerly scytalidopepsin A) is a serine-carboxyl peptidase of the sedolisin family
Biosci. Biotechnol. Biochem.
72
2239-2242
2008
Scytalidium lignicola
Xu, Q.; Yao, J.; Wlodawer, A.; Guo, H.
Clarification of the mechanism of acylation reaction and origin of substrate specificity of the serine-carboxyl peptidase sedolisin through QM/MM free energy simulations
J. Phys. Chem. B
115
2470-2476
2011
Pseudomonas sp. (P42790)
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