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3.4.17.3: lysine carboxypeptidase

This is an abbreviated version!
For detailed information about lysine carboxypeptidase, go to the full flat file.

Word Map on EC 3.4.17.3

Reaction

Release of a C-terminal basic amino acid, preferentially lysine =

Synonyms

activated thrombin-activable fibrinolysis inhibitor, anaphylatoxin inactivator, Arginine carboxypeptidase, bradykinase, bradykinin-decomposing enzyme, bradykininase, carboxypeptidase B, carboxypeptidase N, carboxypeptidase N1, carboxypeptidase, arginine, CPase N, CPB, CPE, CPN, CPN1, creatine kinase conversion factor, creatinine kinase convertase, EC 3.4.12.7, hippuryllysine hydrolase, kininase I, kininase Ia, peptidyl-L-lysine(-L-arginine) hydrolase, plasma carboxypeptidase, Plasma carboxypeptidase B, proCPB, protaminase, SCPN, TAFI, TAFIa, thrombin-activatable carboxypeptidase B, thrombin-activatable fibrinolysis inhibitor, thrombin-activatable procarboxypeptidase B

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.17 Metallocarboxypeptidases
                3.4.17.3 lysine carboxypeptidase

Substrates Products

Substrates Products on EC 3.4.17.3 - lysine carboxypeptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-Phe-Ser-Pro-Phe-Arg + H2O
acetyl-Phe-Ser-Pro-Phe + Arg
show the reaction diagram
-
-
-
-
?
activated complement C3a + H2O
?
show the reaction diagram
-
-
-
-
?
activated complement C5a + H2O
?
show the reaction diagram
-
-
-
-
?
Ala-Ser-His-Leu-Gly-Leu-Ala-Arg + H2O
Ala-Ser-His-Leu-Gly-Leu-Ala + Arg
show the reaction diagram
-
reaction is less efficient than reaction with EC 3.4.17.20
-
?
anaphylatoxin + H2O
?
show the reaction diagram
-
-
-
-
?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + Arg
show the reaction diagram
benzoyl-Ala-Arg + H2O
benzoyl-Ala + Arg
show the reaction diagram
-
-
-
-
?
benzoyl-Ala-Lys + H2O
?
show the reaction diagram
-
-
-
-
?
benzoyl-argininic acid + H2O
?
show the reaction diagram
-
-
-
-
?
benzoyl-Gly-Arg + H2O
benzoyl-Gly + Arg
show the reaction diagram
benzoyl-Gly-argininic acid + H2O
benzoyl-Gly + argininic acid
show the reaction diagram
benzoyl-Gly-Lys + H2O
benzoyl-Gly + Lys
show the reaction diagram
benzyloxycarbonyl-Ala-Arg + H2O
benzyloxycarbonyl-Ala + Arg
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Val-Gly-Lys-Lys + H2O
Lys + benzyloxycarbonyl-Val-Gly-Lys
show the reaction diagram
-
-
-
?
bradykinin + H2O
?
show the reaction diagram
C3a69-77 + H2O
?
show the reaction diagram
C5a66-74 + H2O
?
show the reaction diagram
chemerin + H2O
?
show the reaction diagram
dansyl-Phe-Ala-Arg + H2O
dansyl-Phe-Ala + L-arginine
show the reaction diagram
-
-
-
-
?
fibrinopeptide A + H2O
Arg + ?
show the reaction diagram
-
very low activity
-
?
fibrinopeptide alphaArg96-104 + H2O
?
show the reaction diagram
-
-
-
?
fibrinopeptide B + H2O
Arg + ?
show the reaction diagram
-
-
-
?
fibrinopeptide betaLys125-133 + H2O
?
show the reaction diagram
-
-
-
?
fibrinopeptide gammaLys54-62 + H2O
?
show the reaction diagram
-
-
-
?
fibrinopeptide gammaLys77-85 + H2O
?
show the reaction diagram
-
-
-
?
fibrinopeptide-alpha-Arg96-104 + H2O
?
show the reaction diagram
-
-
-
?
fibrinopeptide-beta-Lys125-133 + H2O
?
show the reaction diagram
-
-
-
?
fibrinopeptide-gamma-Lys54-62 + H2O
?
show the reaction diagram
-
-
-
?
fibrinopeptide-gamma-Lys77-85 + H2O
?
show the reaction diagram
-
-
-
?
furylacryloyl-Ala-Arg + H2O
furylacryloyl-Ala + Arg
show the reaction diagram
-
-
-
-
?
furylacryloyl-Ala-L-Lys + H2O
furylacryloylalanine-Ala + Lys
show the reaction diagram
furylacryloyl-Gly-Arg + H2O
furylacryloyl-Gly + Arg
show the reaction diagram
-
-
-
-
?
furylacryloyl-Gly-Lys + H2O
furylacryloyl-Gly + Lys
show the reaction diagram
-
-
-
-
?
furylacryloyl-L-Ala-L-Lys + H2O
furylacryloyl-L-Ala + Lys
show the reaction diagram
-
-
-
-
?
Gly-His-Lys + H2O
Gly-His + Lys
show the reaction diagram
-
-
-
?
hippuryl-Arg + H2O
hippuric acid + Arg
show the reaction diagram
Hippuryl-L-Arg + H2O
Hippuric acid + L-Arg
show the reaction diagram
Hippuryl-L-argininic acid + H2O
Hippuric acid + argininic acid
show the reaction diagram
-
-
-
-
?
hippuryl-L-His-L-Leu + H2O
hippuryl-L-His + L-Leu
show the reaction diagram
-
-
-
-
?
Hippuryl-L-Lys + H2O
Hippuric acid + L-Lys
show the reaction diagram
hippuryl-L-Lys-L-Leu + H2O
hippuryl-L-Lys + L-Leu
show the reaction diagram
-
-
-
-
?
His-Lys-Asp-Met-Gln-Leu-Gly-Arg + H2O
His-Lys-Asp-Met-Gln-Leu-Gly + Arg
show the reaction diagram
-
i.e. C5a, reaction is less efficient than reaction with EC 3.4.17.20
-
?
His-tagged C3f peptide + H2O
?
show the reaction diagram
-
CPN cleaves the C-terminal Arg of C3f_R1310-R1320 to produce C3f_R1310-L1319
-
-
?
kallikrein + H2O
?
show the reaction diagram
-
plasma or urinary
-
-
?
kinin + H2O
?
show the reaction diagram
-
-
-
-
?
Leu-Trp-Met-Arg + H2O
Leu-Trp-Met + Arg
show the reaction diagram
-
-
-
?
Phe-Ser-Pro-Phe-Arg + H2O
Phe-Ser-Pro-Phe + Arg
show the reaction diagram
-
-
-
-
?
plasmin + H2O
?
show the reaction diagram
-
-
-
-
?
polylysine + H2O
Lys
show the reaction diagram
Pro-Gly-Lys-Ala-Arg + H2O
Pro-Gly-Lys-Ala + Arg
show the reaction diagram
-
-
-
?
Pro-Phe-Gly-Lys + H2O
Pro-Phe-Gly + Lys
show the reaction diagram
-
-
-
?
Pro-Phe-Lys + H2O
Pro-Phe + Lys
show the reaction diagram
-
-
-
-
?
Pro-Phe-Lys-Gly + H2O
Pro-Phe-Lys + Gly
show the reaction diagram
-
-
-
-
?
prochemerin + H2O
?
show the reaction diagram
salmine + H2O
Arg + ?
show the reaction diagram
-
-
-
?
Thr-Pro-Arg-Lys + H2O
Thr-Pro-Arg + Lys
show the reaction diagram
-
-
-
?
thrombin-cleaved osteopontin + H2O
?
show the reaction diagram
-
-
-
-
?
trypsin + H2O
?
show the reaction diagram
-
-
-
-
?
YFPGQFAFSK + H2O
YFPGQFAFS + lysine
show the reaction diagram
bioacivity of 10-mer chemerin peptide, chemerin 149-158, is enhanced by removing the carboxyl-terminal lysine
-
-
?
YFPGQFAFSKALPRS + H2O
?
show the reaction diagram
sequential cleavage of prochemerin peptide, chemerin 149-163, by CPB increases chemotactic activities
-
-
?
additional information
?
-