3.4.17.3: lysine carboxypeptidase
This is an abbreviated version!
For detailed information about lysine carboxypeptidase, go to the full flat file.
Word Map on EC 3.4.17.3
-
3.4.17.3
-
angiotensin
-
anaphylatoxins
-
endopeptidase
-
angiotensin-converting
-
captopril
-
c3a
-
kallikrein
-
fibrinolysis
-
phosphoramidon
-
kallikrein-kinin
-
procarboxypeptidase
-
mergetpa
-
angioedema
-
dl-2-mercaptomethyl-3-guanidinoethylthiopropanoic
-
hippuryl-l-arginine
-
des-arg9-bk
-
bradykinin-induced
-
enkephalinase
-
enalaprilat
-
prekallikrein
-
des-arg9-bradykinin
-
3.4.15.1
-
kallidin
-
amastatin
-
tafia
-
kininogenase
-
medicine
- 3.4.17.3
- angiotensin
- anaphylatoxins
- endopeptidase
-
angiotensin-converting
- captopril
- c3a
- kallikrein
-
fibrinolysis
- phosphoramidon
-
kallikrein-kinin
-
procarboxypeptidase
- mergetpa
- angioedema
-
dl-2-mercaptomethyl-3-guanidinoethylthiopropanoic
- hippuryl-l-arginine
-
des-arg9-bk
-
bradykinin-induced
- enkephalinase
- enalaprilat
- prekallikrein
- des-arg9-bradykinin
-
3.4.15.1
- kallidin
- amastatin
- tafia
- kininogenase
- medicine
Reaction
Release of a C-terminal basic amino acid, preferentially lysine =
Synonyms
activated thrombin-activable fibrinolysis inhibitor, anaphylatoxin inactivator, Arginine carboxypeptidase, bradykinase, bradykinin-decomposing enzyme, bradykininase, carboxypeptidase B, carboxypeptidase N, carboxypeptidase N1, carboxypeptidase, arginine, CPase N, CPB, CPE, CPN, CPN1, creatine kinase conversion factor, creatinine kinase convertase, EC 3.4.12.7, hippuryllysine hydrolase, kininase I, kininase Ia, peptidyl-L-lysine(-L-arginine) hydrolase, plasma carboxypeptidase, Plasma carboxypeptidase B, proCPB, protaminase, SCPN, TAFI, TAFIa, thrombin-activatable carboxypeptidase B, thrombin-activatable fibrinolysis inhibitor, thrombin-activatable procarboxypeptidase B
ECTree
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Reference on EC 3.4.17.3 - lysine carboxypeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ryan, J.
Arginine carboxypeptidase and its inhibitors
Methods Enzymol.
163
186-194
1988
Homo sapiens
Skidgel, R.A.; Erdös, E.G.
Carboxypeptidase N (arginine carboxypeptidase)
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
5
60-72
1984
Homo sapiens
-
Plummer, T.H.; Erdös, E.G.
Human plasma carboxypeptidase N
Methods Enzymol.
80
442-449
1981
Homo sapiens
Plummer, T.H.; Hurwitz, M.Y.
Human plasma carboxypeptidase N. Isolation and characterization
J. Biol. Chem.
253
3907-3912
1978
Homo sapiens
Fricker, L.D.; Plummer, T.H.; Snyder, S.H.
Enkephalin convertase: potent, selective, and irreversible inhibitors
Biochem. Biophys. Res. Commun.
111
994-1000
1983
Homo sapiens
Tan, F.; Weerasinghe, D.K.; Skidgel, R.A.; Tamei, H.; Kaul, R.K.; Roninson, I.B.; Schilling, J.W.; Erdös, E.G.
The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats [published erratum appears in J Biol Chem 1990 Jul 25;265(21):12749
J. Biol. Chem.
265
13-19
1990
Homo sapiens
Levin, Y.; Skidgel, R.A.; Erdös, E.G.
Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase i)
Proc. Natl. Acad. Sci. USA
79
4618-4622
1982
Homo sapiens
Oshima, G.; Kato, J.; Erdös, E.G.
Plasma carboxypeptidase N, subunits and characteristics
Arch. Biochem. Biophys.
170
132-138
1975
Homo sapiens
Oshima, G.; Kato, J.; Erdös, E.G.
Subunits of human plasma carboxypeptidase N (kininase I, anaphylatoxin inactivator)
Biochim. Biophys. Acta
365
344-348
1974
Homo sapiens, Sus scrofa
-
Hendriks, D.; Scharpe, S.; van Sande, M.
Carboxypeptidase N activity in human tissues and fluids
Biochem. Soc. Trans.
14
1048
1986
Homo sapiens
-
Grimwood, B.G.; Plummer, T.H.; Tarentino, A.L.
Characterization of the carboxypeptidase N secreted by Hep G2 cells
J. Biol. Chem.
263
14397-14401
1988
Homo sapiens
Jeanneret, L.; Roth, M.; Bargetzi, J.P.
Carboxypeptidase N from pig serum
Hoppe-Seyler's Z. Physiol. Chem.
357
867-872
1976
Sus scrofa
Juillerat-Jeanneret, L.; Roth, M.; Bargetzi, J.P.
Some properties of porcine carboxypeptidase N
Hoppe-Seyler's Z. Physiol. Chem.
363
51-58
1982
Sus scrofa
Moriguchi, M.; Umeda, Y.; Miyazaki, K.; Nakamura, T.; Ogawa, K.; Kojima, F.; Iinuma, H.; Aoyagi, T.
Synthesis of histargin and related compounds and their inhibition of enzymes
J. Antibiot.
41
1823-1827
1988
Homo sapiens
Gebhard, W.; Schube, M.; Eulitz, M.
cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1)
Eur. J. Biochem.
178
603-607
1989
Homo sapiens
Plummer, T.H.; Kimmel, M.T.
An improved spectrophotometric assay for human plasma carboxypeptidase N1
Anal. Biochem.
108
348-353
1980
Homo sapiens
Hendriks, D.; Scharpe, S.; van Sande, M.
Assay of carboxypeptidase N activity in serum by liquid-chromatographic determination of hippuric acid
Clin. Chem.
31
1936-1939
1985
Homo sapiens
Koheil, A.; Forstner, G.
Isoelectric focusing of carboxypeptidase N
Biochim. Biophys. Acta
524
156-161
1978
Homo sapiens
Skidgel, R.A.; Weerasinghe, D.K.; Erdös, E.G.
Structure of human carboxypeptidase N (kininase I)
Adv. Exp. Med. Biol.
247A
325-329
1989
Homo sapiens
Linder, L.E.; Sund, M.L.; Lönnies, H.
Isolation and purification of cell wall-associated arginine carboxypeptidase from Streptococcus mitis ATCC 15909
Curr. Microbiol.
28
91-96
1994
Streptococcus mitis
-
Wang, W.; Hendriks, D.F.; Scharpe, S.L.
Immobilized carboxypeptidase N. A potent bioreactor and specific adsorbent for peptides
Appl. Biochem. Biotechnol.
44
151-160
1994
Homo sapiens
McCleave, M.J.; Elliott, R.J.; Archbold, G.P.
Human plasma carboxypeptidase N; stability of enzyme activity following collection
Biochem. Soc. Trans.
24
42S
1996
Homo sapiens
Barabe, J.; Huberdeau, D.
A micromethod for the determination of the activities of kininases in rat plasma. Kinetics and inhibitory characteristics
Biochem. Pharmacol.
41
821-827
1991
Rattus norvegicus
Orawski, A.T.; Susz, J.P.; Simmons, W.H.
Metabolism of bradykinin by multiple coexisting membrane-bound peptidases in lung: techniques for investigating the role of each peptidase using specific inhibitors
Adv. Exp. Med. Biol.
247B
355-364
1989
Bos taurus, Rattus norvegicus
Schweisfurth, H.
Carboxypeptidase N
Dtsch. Med. Wochenschr.
109
1254-1258
1984
Homo sapiens
Lazoura, E.; Campbell, W.; Yamaguchi, Y.; Kato, K.; Okada, N.; Okada, H.
Rational structure-based design of a novel carboxypeptidase R inhibitor
Chem. Biol.
9
1129-1139
2002
Homo sapiens
Sato, T.; Miwa, T.; Akatsu, H.; Matsukawa, N.; Obata, K.; Okada, N.; Campbell, W.; Okada, H.
Pro-carboxypeptidase R is an acute phase protein in the mouse, whereas carboxypeptidase N is not
J. Immunol.
165
1053-1058
2000
Mus musculus (Q9JJN5), Mus musculus
Suzuki, K.; Muto, Y.; Fushihara, K.; Kanemoto, K.; Iida, H.; Sato, E.; Kikuchi, C.; Matsushima, T.; Kato, E.; Nomoto, M.; Yoshioka, S.; Ishii, H.
Enhancement of fibrinolysis by EF6265 [(S)-7-amino-2-[[[(R)-2-methyl-1-(3-phenylpropanoylamino)propyl]hydroxypho sphinoyl] methyl]heptanoic acid], a specific inhibitor of plasma carboxypeptidase B
J. Pharmacol. Exp. Ther.
309
607-615
2004
Homo sapiens, Rattus norvegicus
Kato, T.; Akatsu, H.; Sato, T.; Matsuo, S.; Yamamoto, T.; Campbell, W.; Hotta, N.; Okada, N.; Okada, H.
Molecular cloning and partial characterization of rat procarboxypeptidase R and carboxypeptidase N
Microbiol. Immunol.
44
719-728
2000
Rattus norvegicus
Campbell, W.D.; Lazoura, E.; Okada, N.; Okada, H.
Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N
Microbiol. Immunol.
46
131-134
2002
Homo sapiens
Komura, H.; Shimomura, Y.; Yumoto, M.; Katsuya, H.; Okada, N.; Okada, H.
Heat stability of carboxypeptidase R of experimental animals
Microbiol. Immunol.
46
217-223
2002
Cavia porcellus, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Davis, D.A.; Singer, K.E.; De La Luz Sierra, M.; Narazaki, M.; Yang, F.; Fales, H.M.; Yarchoan, R.; Tosato, G.
Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation
Blood
105
4561-4568
2005
Homo sapiens
Matthews, K.W.; Drouin, S.M.; Liu, C.; Martin, J.F.; Skidgel, R.A.; Wetsel, R.A.
Expression of the third complement component (C3) and carboxypeptidase N small subunit (CPN1) during mouse embryonic development
Dev. Comp. Immunol.
28
647-655
2004
Mus musculus
Matthews, K.W.; Mueller-Ortiz, S.L.; Wetsel, R.A.
Carboxypeptidase N: a pleiotropic regulator of inflammation
Mol. Immunol.
40
785-793
2004
Homo sapiens, Mus musculus
Leung, L.L.; Nishimura, T.; Myles, T.
Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI)
Adv. Exp. Med. Biol.
632
61-69
2008
Mus musculus
Du, X.Y.; Zabel, B.A.; Myles, T.; Allen, S.J.; Handel, T.M.; Lee, P.P.; Butcher, E.C.; Leung, L.L.
Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets
J. Biol. Chem.
284
751-758
2009
Homo sapiens, Homo sapiens (P15169)
Leung, L.L.; Myles, T.; Nishimura, T.; Song, J.J.; Robinson, W.H.
Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI)
Mol. Immunol.
45
4080-4083
2008
Mus musculus
Talens, S.; Lebbink, J.H.; Malfliet, J.J.; Demmers, J.A.; Uitte de Willige, S.; Leebeek, F.W.; Rijken, D.C.
Binding of carboxypeptidase N to fibrinogen and fibrin
Biochem. Biophys. Res. Commun.
427
421-425
2012
Homo sapiens
Li, Y.; Li, Y.; Chen, T.; Kuklina, A.S.; Bernard, P.; Esteva, F.J.; Shen, H.; Ferrari, M.; Hu, Y.
Circulating proteolytic products of carboxypeptidase N for early detection of breast cancer
Clin. Chem.
60
233-242
2014
Mus musculus
Helwig, M.; Herwig, A.; Heldmaier, G.; Barrett, P.; Mercer, J.G.; Klingenspor, M.
Photoperiod-dependent regulation of carboxypeptidase E affects the selective processing of neuropeptides in the seasonal Siberian hamster (Phodopus sungorus)
J. Neuroendocrinol.
25
190-197
2013
Phodopus sungorus
Leung, L.L.K.; Morser, J.
Carboxypeptidase B2 and carboxypeptidase N in the crosstalk between coagulation, thrombosis, inflammation, and innate immunity
J. Thromb. Haemost.
16
1474-1486
2018
Mus musculus (Q9JJN5)
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