3.4.17.3: lysine carboxypeptidase

This is an abbreviated version!
For detailed information about lysine carboxypeptidase, go to the full flat file.

Word Map on EC 3.4.17.3

3.4.17.3

angiotensin

anaphylatoxins

endopeptidase

angiotensin-converting

captopril

c3a

kallikrein

fibrinolysis

phosphoramidon

kallikrein-kinin

procarboxypeptidase

mergetpa

angioedema

dl-2-mercaptomethyl-3-guanidinoethylthiopropanoic

hippuryl-l-arginine

des-arg9-bk

bradykinin-induced

enkephalinase

enalaprilat

prekallikrein

des-arg9-bradykinin

3.4.15.1

kallidin

amastatin

tafia

kininogenase

medicine

Reaction

Release of a C-terminal basic amino acid, preferentially lysine =

Synonyms

activated thrombin-activable fibrinolysis inhibitor, anaphylatoxin inactivator, Arginine carboxypeptidase, bradykinase, bradykinin-decomposing enzyme, bradykininase, carboxypeptidase B, carboxypeptidase N, carboxypeptidase N1, carboxypeptidase, arginine, CPase N, CPB, CPE, CPN, CPN1, creatine kinase conversion factor, creatinine kinase convertase, EC 3.4.12.7, hippuryllysine hydrolase, kininase I, kininase Ia, peptidyl-L-lysine(-L-arginine) hydrolase, plasma carboxypeptidase, Plasma carboxypeptidase B, proCPB, protaminase, SCPN, TAFI, TAFIa, thrombin-activatable carboxypeptidase B, thrombin-activatable fibrinolysis inhibitor, thrombin-activatable procarboxypeptidase B

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.17 Metallocarboxypeptidases

3.4.17.3 lysine carboxypeptidase

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Results	in table
4	Activating Compound
21	AA Sequence
2	Application
1	CAS Registry Number
5	Cloned(Commentary)
202	Disease/ Diagnostics
2	Expression
6	General Information
5	General Stability
2	IC50 Value
61	Inhibitors
42	KM Value [mM]
9	Localization
10	Metals/Ions
26	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
52	Organism
1	PDB ID
5	pH Optimum
1	pH Range
10	Posttranslational Modification
8	Purification (Commentary)
1	Reaction
4	Reaction Type
51	Reference
78	Source Tissue
11	Specific Activity [micromol/min/mg]
2	Storage Stability
126	Substrates and Products (Substrate)
13	Subunits
64	Synonyms
4	Temperature Optimum [°C]
6	Temperature Stability [°C]
25	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.17.3 - lysine carboxypeptidase

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0.28

benzoyl-Ala-Arg

-

-

0.25 - 0.35

Benzoyl-Ala-Lys

show

0.1 - 6.7

benzoyl-Gly-Arg

show

1.4 - 6.3

Benzoyl-Gly-Lys

show

0.0004 - 0.706

bradykinin

show

0.035 - 0.077

C3a69-77

show

0.219 - 0.602

C5a66-74

show

0.1228 - 0.17

chemerin

show

-

0.13

des-Arg9-bradykinin

-

-

0.361 - 0.448

fibrinopeptide alphaArg96-104

show

-

0.0532 - 0.143

fibrinopeptide betaLys125-133

show

-

0.34 - 0.657

fibrinopeptide gammaLys54-62

show

-

0.238 - 3.727

fibrinopeptide gammaLys77-85

show

-

0.3614

fibrinopeptide-alpha-Arg96-104

-

-

0.0143

fibrinopeptide-beta-Lys125-133

-

-

0.034

fibrinopeptide-gamma-Lys54-62

-

-

0.2389

fibrinopeptide-gamma-Lys77-85

-

-

0.26

furylacryloyl-Ala-Arg

-

-

0.34

furylacryloyl-L-Ala-L-Lys

-

-

-

0.3

furylacryloylalanyl-L-Lys

-

-

0.14 - 1.8

hippuryl-Arg

show

1.2 - 6.93

hippuryl-L-Arg

show

0.3

Hippuryl-L-argininic acid

-

-

3.3 - 35.8

Hippuryl-L-Lys

show

5.9

Leu-Trp-Met-Arg

-

-

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Release 2023.1 (January 2023)