3.4.14.4: dipeptidyl-peptidase III

This is an abbreviated version!
For detailed information about dipeptidyl-peptidase III, go to the full flat file.

Word Map on EC 3.4.14.4

3.4.14.4

exopeptidase

tynorphin

enkephalin-degrading

leu-enkephalin

nudix

spinorphin

hexxh

map2k5

medicine

Reaction

release of an N-terminal dipeptide from a peptide comprising four or additional information residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides. =

Synonyms

BT_1846, Cabys_2252, dipeptdiyl peptidase III, dipeptidyl aminopeptidase III, dipeptidyl arylamidase III, dipeptidyl peptidase III, dipeptidyl-peptidase III, dipeptidyl-peptide hydrolase, dipeptidylpeptidase III, DPP III, DPP-3, DPP-III, DPP3, DPPIII, enkephalinase B, NUDT3, peptidase, dipeptidyl, III, PG_0317, PHYPA_007037, red cell angiotensinase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

3.4.14.4 dipeptidyl-peptidase III

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Results	in table
2	Activating Compound
2426	AA Sequence
3	Application
1	CAS Registry Number
13	Cloned(Commentary)
9	Crystallization (Commentary)
83	Disease/ Diagnostics
1	Expression
2	General Information
2	General Stability
27	IC50 Value
274	Inhibitors
40	kcat/KM [mM/s]
60	Ki Value [mM]
65	KM Value [mM]
24	Localization
32	Metals/Ions
29	Molecular Weight [Da]
2	Organic Solvent Stability
148	Organism
22	PDB ID
33	pH Optimum
6	pH Range
4	pH Stability
4	pI Value
1	Posttranslational Modification
41	Protein Variants
31	Purification (Commentary)
1	Reaction
9	Reaction Type
77	Reference
1	Renatured (Commentary)
54	Source Tissue
30	Specific Activity [micromol/min/mg]
5	Storage Stability
160	Substrates and Products (Substrate)
22	Subunits
57	Synonyms
12	Temperature Optimum [°C]
3	Temperature Range [°C]
13	Temperature Stability [°C]
51	Turnover Number [1/s]

Purification

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Purification on EC 3.4.14.4 - dipeptidyl-peptidase III

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11 entries

about 28% yield after gel filtration and FPLC for wild-type enzyme

Homo sapiens

Q9NY33

707660

by gel filtration on a Sephacryl S-200 column, followed by FPLC on a Mono Q column, recombinant and human erythtocyte DPP III is purified

Homo sapiens

Q9NY33

683209

DPP from goat brain is purified by several steps, including acid precipitation, ammonium sulfate fractionation, chromatography on a Sephadex G-100 column, cation, anion and adsorption chromatography

Capra hircus

684026

expressed in Escherichia coli

from seed

gel filtration and FPLC on Mono Q column

Saccharomyces cerevisiae

Q08225

707596

Hi-Trap Q Sepharose chromatography

Drosophila melanogaster

Q9VHR8

668562

human DPP III is purified from healthy blood donor erythrocytes

Homo sapiens

678581

Ni-NTA resin column chromatography

Saccharomyces cerevisiae

partial

recombinant enzyme

the protein is purified from human erythrocytes

Homo sapiens

683203