Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.14.4: dipeptidyl-peptidase III

This is an abbreviated version!
For detailed information about dipeptidyl-peptidase III, go to the full flat file.

Word Map on EC 3.4.14.4

Reaction

release of an N-terminal dipeptide from a peptide comprising four or additional information residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides. =

Synonyms

BT_1846, Cabys_2252, dipeptdiyl peptidase III, dipeptidyl aminopeptidase III, dipeptidyl arylamidase III, dipeptidyl peptidase III, dipeptidyl-peptidase III, dipeptidyl-peptide hydrolase, dipeptidylpeptidase III, DPP III, DPP-3, DPP-III, DPP3, DPPIII, enkephalinase B, NUDT3, peptidase, dipeptidyl, III, PG_0317, PHYPA_007037, red cell angiotensinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
                3.4.14.4 dipeptidyl-peptidase III

Inhibitors

Inhibitors on EC 3.4.14.4 - dipeptidyl-peptidase III

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
1,3-di-[5-(2-imidazolinyl)-2-benzimidazolyl]-2,4-di-o-chlorophenyl-cyclobutane dihydrochloride
-
-
1,3-di-[5-(2-imidazolinyl)-2-benzimidazolyl]-2,4-di-phenyl-cyclobutane dihydrochloride
-
-
1,3-di-[5-(2-imidazolinyl)-2-benzoimidazolyl]-2,4-di-(2-furyl)-cyclobutane dihydrochloride
-
-
1,3-di-[5-(2-imidazolinyl)-2-benzoimidazolyl]-2,4-di-(2-thienyl)-cyclobutane dihydrochloride
-
-
1,3-di-[5-(2-imidazolinyl)-2-benzoimidazolyl]-2,4-di-(2-thienyl)-cyclobutanedihydrochloride
-
-
1,3-di-[5-(N-amidino)-2-benzimidazolyl]-2,4-di-o-chlorophenyl-cyclobutane dihydrochloride
-
-
1,3-di-[5-(N-amidino)-2-benzimidazolyl]-2,4-di-phenyl-cyclobutane dihydrochloride
-
-
1,3-di-[5-(N-isopropylamidino)-2-benzimidazolyl]-2,4-di-o-chlorophenyl-cyclobutane dihydrochloride
-
-
1,3-di-[5-(N-isopropylamidino)-2-benzimidazolyl]-2,4-di-o-chlorophenylcyclobutane dihydrochloride
-
-
1,3-di-[5-(N-isopropylamidino)-2-benzimidazolyl]-2,4-di-phenyl-cyclobutane dihydrochloride
-
-
1-ethyl-3(3-dimethyl-amino-propyl)-carbodiimide*HCl
-
1.0 mM inhibitor, 29% inhibition, 5.0 mM inhibitor, 64% inhibition
2,2'-dithiodipyridine
-
1.0 mM inhibitor, 32% inhibition, 2.5 mM inhibitor, 98% inhibition
2,4,6-trinitrobenzene sufonic acid trihydrate
-
1.0 mM inhibitor, 52% inhibition, 2.5 mM inhibitor, 89% inhibition
2-(3H-imidazol-4-yl)-1H-benzoimidazole-5-carboxamidine hydrochloride
-
complete inhibition at 0.1 mM
2-(3H-imidazol-4-yl)-1H-benzoimidazole-5-imidazolinylamidine hydrochloride
-
complete inhibition at 0.1 mM
2-mercaptoethanol
2-[(E)-2-phenylethenyl]-1H-benzimidazole
-
-
3,3'-dithiobis(6-nitrobenzoic acid)
-
13% residual activity at 2.5 mM, beta-mercaptoethanol and dithiothreitlol completely restores enzyme activity
3,4-dichloroisocoumarin
4,4'-dithiodipyridine
inactivation of wild-type dipeptidyl peptidase III after incubation at pH 8.0 at 25°C, after 5 min incubation loss of 30% enzyme activity, after 15 min incubation loss of 62% enzyme activity
4-(2-aminoethyl) benzenesulfonyl fluoride
-
0.01 mM, 89% inhibition
4-Chlorobenzoic acid
-
0.5 mM, 42% inhibition
4-nitrophenyl iodoacetate
-
0.5 mM, 57% inhibition
5,5'-dithiobis(2-nitrobenzoate)
6-(4,5-dihydro-1H-imidazol-2-yl)-2-[(E)-2-phenylethenyl]-1H-benzimidazole
Acetyl-L-Leu-L-arginal
-
-
AEBSF
-
0.2 mM, 84% inhibition
alpha1 anti-trypsin
-
1.0 mM inhibitor, 61% inhibition
-
amastatin
-
30% inhibition at 0.1 mM
amino([(5-([(2R)-1-methoxy-3-(6-methylphenanthridin-8-yl)-1-oxopropan-2-yl]carbamoyl)-1H-pyrrol-2-yl)carbonyl]amino)methaniminium chloride
0.035 mM, 45% inhibition
amino[((5-[(2-([(2R)-1-methoxy-3-(6-methylphenanthridin-8-yl)-1-oxopropan-2-yl]amino)-2-oxoethyl)carbamoyl]-1H-pyrrol-2-yl)carbonyl)amino]methaniminium chloride
0.06 mM, 33% inhibition
angiotensin II
angiotensin III
angiotensins
-
-
-
Aprotinin
Arg-Arg
Arg-Arg-2-naphthylamide
-
above 0.1 mM
benzamidine HCl
-
1.0 mM inhibitor, 29% inhibition, 5.0 mM inhibitor, 61% inhibition
bestatin
bis-p-nitrophenyl phosphate
-
-
Ca2+
-
0.2 mM, 40% inhibition
Co2+
-
activation up to 50% at 0.001-0.0001 mM, inbhibitory above 0.002 mM
cysteine
-
-
diisopropylfluorophosphate
dimethyl sulfoxide
-
inhibitory effect with more than 5% (v/v) dimethyl sulfoxide
dithioerythreitol
-
-
dithiothreitol
DTNB
-
1.0 mM inhibitor, 54% inhibition, 2.5 mM inhibitor, 87% inhibition
E-64
-
i.e. L-trans-epoxysuccinyl-leucylamido(4-guanidino)butane, 10% inhibition at 0.1 mM
Egg white trypsin inhibitor
-
1.0 mM inhibitor, 34% inhibition
-
EGTA
96% inhibition in the presence of 1 mM EGTA, but 110% activity in the presence of the two inhibitors 1 mM EGTA and 1 mM Zn2+
ethanol
-
the enzyme loses about half of its activity at 5% (v/v) ethanol
genistein
-
glutathione
-
-
Gly-Gly-Phe-Leu
Gly-L-Glu
-
36% inhibition at 1 mM
Gly-L-Phe
-
46% inhibition at 1 mM
Gly-L-Phe-L-Leu
-
non-competitive inhibitor, 82% inhibition at 1 mM
H-Phe-Gly-NHOH
H-Phe-Leu-NHOH
H-Phe-Phe-NHOH
H-Tyr-Phe-NHOH
His-Phe-Arg-Trp
iodoacetamide
iodoacetic acid
-
1.0 mM inhibitor, 25% inhibition, 5.0 mM inhibitor, 48% inhibition
IVYPW
-
hemorphin.like peptide, non-competitive, 50% inhibition at 0.00016 mM
kaempferol
-
L-Ala-L-Ala-L-Ala
-
4% inhibition at 1 mM
L-Ala-L-Ala-L-Ala-L-Ala
-
58% inhibition at 0.5 mM
L-Arg-L-Phe
-
56% inhibition at 1 mM
L-Arg-L-Phe-L-Ala
-
competitive inhibitor, 99% inhibition at 1 mM
L-Arg-L-Trp
-
46% inhibition at 1 mM
L-Arg-L-Val
-
49% inhibition at 1 mM
L-Asp-L-Ala
-
25% inhibition at 1 mM
L-His-L-Leu
-
76% inhibition at 1 mM
L-His-L-Lys
-
41% inhibition at 1 mM
L-His-L-Phe
-
46% inhibition at 1 mM
L-His-L-Pro
-
16% inhibition at 1 mM
L-Ile-L-His
-
34% inhibition at 1 mM
L-Leu-L-Arg
-
complete inhibition at 0.5 mM
L-Leu-L-Trp
-
competitive inhibitor, 90% inhibition at 1 mM
L-Leu-L-Trp-L-Met
-
competitive inhibitor, 92% inhibition at 1 mM
L-Leu-L-Trp-L-Met-L-Arg-L-Phe-L-Ala
-
competitive inhibitor, complete inhibition at 1 mM
L-Lys-L-Ala
-
23% inhibition at 1 mM
L-Met-L-Arg
-
99% inhibition at 1 mM
L-Phe-L-Ala
-
41% inhibition at 1 mM
L-Phe-L-Arg
-
75% inhibition at 1 mM
L-Phe-L-Leu
-
58% inhibition at 1 mM
L-Phe-L-Met
-
85% inhibition at 1 mM
L-Pro-L-Arg-OH
-
54% inhibition at 1 mM
L-Pro-L-Glu
-
34% inhibition at 1 mM
L-Pro-L-Phe
-
56% inhibition at 1 mM
L-Ser-L-Met
-
32% inhibition at 1 mM
L-Trp-L-Met
-
competitive inhibitor, 94% inhibition at 1 mM
L-Trp-L-Met-L-Asp-L-Phe
-
82% inhibition at 1 mM
L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide
-
competitive inhibition
L-Tyr-Gly
-
31% inhibition at 1 mM
L-Tyr-Gly-Gly-L-Phe
-
53% inhibition at 1 mM
L-Tyr-L-Ile
-
72% inhibition at 1 mM
L-tyrosyl-glycine hydroxamic acid
-
L-tyrosyl-L-phenylalanine hydroxamic acid
-
L-Val-L-Tyr
-
competitive inhibitor, 84% inhibition at 1 mM
Leu-enkephalin
-
i.e. L-Tyr-Gly-Gly-L-Phe-L-Leu, 92% inhibition at 1 mM, competitive inhibitor
Leu-Trp-Met-Arg-Phe
Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg
-
Leu-valorphin-Arg
leupeptin
Li+
-
73.0% residual activity at 0.1 mM
Lys-Val-Ile-Leu-Phe
Met-enkephalin
-
i.e. L-Tyr-Gly-Gly-L-Phe-L-Met, 61% inhibition at 0.5 mM, competitive inhibitor
methyl N-[5-(carbamimidoylcarbamoyl)-1H-pyrrole-2-carbonyl]-3-[[(pyren-1-yl)methyl]amino]-D-alaninate
0.01 mM, 36% inhibition. Compound is not hydrolysed by enzyme, although the binding affinity is comparable with that of Arg-Arg-2-naphthylamide
N-ethylmaleimide
N-hydroxy-succinimide
-
1.0 mM inhibitor, 30% inhibition, 5.0 mM inhibitor, 51% inhibition
Nalpha-tosyl-L-Phe-chloromethyl ketone
-
60% inhibition at 0.1 mM
o-phenanthroline
p-aminophenyl mercuric acetate
-
1.0 mM inhibitor, 42% inhibition, 2.5 mM inhibitor, 94% inhibition
p-chloromercuribenzoate
p-chloromercuriphenylsulfonic acid
-
-
p-Chlorophenylsulfonate
-
-
p-hydroxymercuribenzoate
p-hydroxymercuriphenyl-sulfonic acid
-
1.0 mM inhibitor, 22% inhibition, 2.5 mM inhibitor, 96% inhibition
p-nitrocatecholsulfate
-
1.0 mM inhibitor, 37% inhibition, 5.0 mM inhibitor, 58% inhibition
Pb(CH3COO)2
-
1.0 mM inhibitor, 53% inhibition, 2.5 mM inhibitor, 97% inhibition
Pb2+
-
-
pepstatin
-
1 mM, 43% inhibition
pepstatin A
-
5.0 mM inhibitor, 92% inhibition
Phenylmethanesulfonylfluoride
probestin
-
85% inhibition at 0.1 mM
Proctolin
Propioxanthin A and B
-
-
-
puromycin
Soybean trypsin inhibitor
-
1.0 mM inhibitor, 64% inhibition, 2.5 mM inhibitor, 76% inhibition
-
thioglycolic acid
-
-
TLCK
-
1.0 mM inhibitor, 27% inhibition, 5.0 mM inhibitor, 63% inhibition
TPCK
-
1.0 mM inhibitor, 75% inhibition, 5.0 mM inhibitor, 88% inhibition
tynorphin
Tyr(SO3H)-Gly-Gly-Phe-Leu
-
-
Tyr-Ala-Gly-Phe-Leu
-
Ala2-Leu-enkephalin
Tyr-Arg
Tyr-D-Ala-Gly-Phe-Leu
-
D-Ala2-Leu-enkephalin
Tyr-Gly-Gly-Phe
-
enkephalin fragment
Tyr-Gly-Gly-Phe-Leu
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile
-
dynorphin A 1-8
Tyr-Gly-Gly-Phe-Met
Tyr-Phe-NHOH
Tyr-Pro-Phe-Phe-NH2
-
endomorphin-2
Tyr-Pro-Phe-Val-Glu-Pro-Ile
-
human beta-casomorphin
Tyr-Pro-Trp-Phe-NH2
-
endomorphin-1
Tyr-Tyr
Urea
-
sensitive to very low concentrations of urea
Val-Val-Tyr-Pro-Trp-Thr-Gln
-
valorphin
WVYPW
-
hemorphin.like peptide, non-competitive, 50% inhibition at 0.00024 mM
additional information
-