3.4.14.4: dipeptidyl-peptidase III

This is an abbreviated version!
For detailed information about dipeptidyl-peptidase III, go to the full flat file.

Word Map on EC 3.4.14.4

3.4.14.4

exopeptidase

tynorphin

enkephalin-degrading

leu-enkephalin

nudix

spinorphin

hexxh

map2k5

medicine

Reaction

release of an N-terminal dipeptide from a peptide comprising four or additional information residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides. =

Synonyms

BT_1846, Cabys_2252, dipeptdiyl peptidase III, dipeptidyl aminopeptidase III, dipeptidyl arylamidase III, dipeptidyl peptidase III, dipeptidyl-peptidase III, dipeptidyl-peptide hydrolase, dipeptidylpeptidase III, DPP III, DPP-3, DPP-III, DPP3, DPPIII, enkephalinase B, NUDT3, peptidase, dipeptidyl, III, PG_0317, PHYPA_007037, red cell angiotensinase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

3.4.14.4 dipeptidyl-peptidase III

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Results	in table
2	Activating Compound
2426	AA Sequence
3	Application
1	CAS Registry Number
13	Cloned(Commentary)
9	Crystallization (Commentary)
83	Disease/ Diagnostics
1	Expression
2	General Information
2	General Stability
27	IC50 Value
274	Inhibitors
40	kcat/KM [mM/s]
60	Ki Value [mM]
65	KM Value [mM]
24	Localization
32	Metals/Ions
29	Molecular Weight [Da]
2	Organic Solvent Stability
148	Organism
22	PDB ID
33	pH Optimum
6	pH Range
4	pH Stability
4	pI Value
1	Posttranslational Modification
41	Protein Variants
31	Purification (Commentary)
1	Reaction
9	Reaction Type
77	Reference
1	Renatured (Commentary)
54	Source Tissue
30	Specific Activity [micromol/min/mg]
5	Storage Stability
160	Substrates and Products (Substrate)
22	Subunits
57	Synonyms
12	Temperature Optimum [°C]
3	Temperature Range [°C]
13	Temperature Stability [°C]
51	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.14.4 - dipeptidyl-peptidase III

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0.0017

1,3-di-[5-(2-imidazolinyl)-2-benzimidazolyl]-2,4-di-o-chlorophenyl-cyclobutane dihydrochloride

2 entries

0.0028

1,3-di-[5-(2-imidazolinyl)-2-benzimidazolyl]-2,4-di-phenyl-cyclobutane dihydrochloride

2 entries

0.008

1,3-di-[5-(2-imidazolinyl)-2-benzoimidazolyl]-2,4-di-(2-furyl)-cyclobutane dihydrochloride

2 entries

0.001

1,3-di-[5-(2-imidazolinyl)-2-benzoimidazolyl]-2,4-di-(2-thienyl)-cyclobutane dihydrochloride

Homo sapiens

678581

0.01

1,3-di-[5-(2-imidazolinyl)-2-benzoimidazolyl]-2,4-di-(2-thienyl)-cyclobutanedihydrochloride

Homo sapiens

at pH 7.4 for 10 min at 25°C

678581

0.007

1,3-di-[5-(N-amidino)-2-benzimidazolyl]-2,4-di-o-chlorophenyl-cyclobutane dihydrochloride

2 entries

0.0056

1,3-di-[5-(N-amidino)-2-benzimidazolyl]-2,4-di-phenyl-cyclobutane dihydrochloride

2 entries

0.006

1,3-di-[5-(N-isopropylamidino)-2-benzimidazolyl]-2,4-di-o-chlorophenyl-cyclobutane dihydrochloride

Homo sapiens

678581

0.006

1,3-di-[5-(N-isopropylamidino)-2-benzimidazolyl]-2,4-di-o-chlorophenylcyclobutane dihydrochloride

Homo sapiens

at pH 7.4 for 10 min at 25°C

678581

0.01

1,3-di-[5-(N-isopropylamidino)-2-benzimidazolyl]-2,4-di-phenyl-cyclobutane dihydrochloride

2 entries

0.053

2-(3H-imidazol-4-yl)-1H-benzoimidazole-5-carboxamidine hydrochloride

2 entries

0.018

2-(3H-imidazol-4-yl)-1H-benzoimidazole-5-imidazolinylamidine hydrochloride

2 entries

0.1

2-[(E)-2-phenylethenyl]-1H-benzimidazole

Homo sapiens

678581

0.01

6-(4,5-dihydro-1H-imidazol-2-yl)-2-[(E)-2-phenylethenyl]-1H-benzimidazole

Homo sapiens

678581

0.0249

fisetin

Homo sapiens

Q9NY33

pH 7.4, 37°C

753237

0.0234

galangin

Homo sapiens

Q9NY33

pH 7.4, 37°C

753237

0.0366

genistein

Homo sapiens

Q9NY33

pH 7.4, 37°C

753237

0.0329

kaempferol

Homo sapiens

Q9NY33

pH 7.4, 37°C

753237

0.022

luteolin

Homo sapiens

Q9NY33

pH 7.4, 37°C

753237