3.4.14.4: dipeptidyl-peptidase III

This is an abbreviated version!
For detailed information about dipeptidyl-peptidase III, go to the full flat file.

Word Map on EC 3.4.14.4

3.4.14.4

exopeptidase

tynorphin

enkephalin-degrading

leu-enkephalin

nudix

spinorphin

hexxh

map2k5

medicine

Reaction

release of an N-terminal dipeptide from a peptide comprising four or additional information residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides. =

Synonyms

BT_1846, Cabys_2252, dipeptdiyl peptidase III, dipeptidyl aminopeptidase III, dipeptidyl arylamidase III, dipeptidyl peptidase III, dipeptidyl-peptidase III, dipeptidyl-peptide hydrolase, dipeptidylpeptidase III, DPP III, DPP-3, DPP-III, DPP3, DPPIII, enkephalinase B, NUDT3, peptidase, dipeptidyl, III, PG_0317, PHYPA_007037, red cell angiotensinase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

3.4.14.4 dipeptidyl-peptidase III

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Results	in table
2	Activating Compound
2426	AA Sequence
3	Application
1	CAS Registry Number
13	Cloned(Commentary)
9	Crystallization (Commentary)
83	Disease/ Diagnostics
1	Expression
2	General Information
2	General Stability
27	IC50 Value
274	Inhibitors
40	kcat/KM [mM/s]
60	Ki Value [mM]
65	KM Value [mM]
24	Localization
32	Metals/Ions
29	Molecular Weight [Da]
2	Organic Solvent Stability
148	Organism
22	PDB ID
33	pH Optimum
6	pH Range
4	pH Stability
4	pI Value
1	Posttranslational Modification
41	Protein Variants
31	Purification (Commentary)
1	Reaction
9	Reaction Type
77	Reference
1	Renatured (Commentary)
54	Source Tissue
30	Specific Activity [micromol/min/mg]
5	Storage Stability
160	Substrates and Products (Substrate)
22	Subunits
57	Synonyms
12	Temperature Optimum [°C]
3	Temperature Range [°C]
13	Temperature Stability [°C]
51	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.14.4 - dipeptidyl-peptidase III

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0.24 - 0.441

Ala-Ala-2-naphthylamide

4 entries

0.005 - 0.0172

Ala-Arg-2-naphthylamide

2 entries

0.00097 - 0.3

Arg-Arg-2-naphthylamide

27 entries

0.031 - 0.035

Arg-Arg-2-naphtylamide

2 entries

0.022

Arg-Arg-4-methoxy-2-naphthylamide

Rattus norvegicus

36183

0.039

Arg-Arg-4-methoxy-beta-naphthylamide

Capra hircus

684026

0.00256 - 0.055

Arg-Arg-4-methylcoumarin 7-amide

2 entries

0.009

Arg-Arg-beta-naphthylamide

Pediococcus acidilactici

pH 8.5, 37°C

754681

0.004

Arg-Tyr-Leu-Pro-Thr

Drosophila melanogaster

25°C

36191

0.329

Gly-Arg-2-naphtylamide

Caldithrix abyssi

H1XW48

pH 7.0, 50°C

755166

0.0945 - 0.2316

L-Ala-L-Ala 2-naphthylamide

3 entries

0.0026 - 0.0251

L-Arg-L-Arg 2-naphthylamide

7 entries

0.07 - 0.2

L-Lys-L-Ala-2-naphthylamide

3 entries

0.0057 - 0.22

Leu-enkephalin

3 entries

0.053

Met-enkephalin

Rattus norvegicus

36179

0.0408

Pro-Arg-2-naphthylamide

Arabidopsis thaliana

Q8L831

pH 7.9, 37°C

752887

0.0038 - 0.0045

Proctolin

3 entries

0.0419

Tyr-Gly-Gly-Phe-Met

Drosophila melanogaster

Q9VHR8

668562

0.0081

Tyr-Pro-Trp-Phe-NH2

Homo sapiens

endomorphin-1

683203