3.4.11.9: Xaa-Pro aminopeptidase

This is an abbreviated version!
For detailed information about Xaa-Pro aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.9

3.4.11.9

aminopeptidases

apstatin

xpnpep2

lactococci

medicine

Reaction

release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide =

Synonyms

aminoacylproline aminopeptidase, aminopeptidase P, aminopeptidase P-like enzyme, aminopeptidase P1, aminopeptidase, aminoacylproline, AMPP, AP-P, APaseP, APP, APP1, APPro, DAP-P, dapUm, Dr-smAPP, Ec-smAPP, ecAPP, hAPP1, hcAMPP, Icp55, LeAPP1, LeAPP2, M24B peptidase, mAmP, Membrane-bound AmP, Membrane-bound APP, membrane-bound proline-specific APaseP, More, Mt-smAPP, Pa-PepP, PEPP, PepQ, peptidase PepQ, PepX aminopeptidase, PfAPP, proline aminopeptidase, sll0136, small aminopeptidase-P, TgAPP, TvMP50, X-Pro aminopeptidase, X-prolyl aminopeptidase, X-prolyl aminopeptidase 2, X-prolyl aminopeptidase 3, X-prolyl peptidase, X-prolyl-dipeptidyl aminopeptidase, Xaa-Pro aminopeptidase, Xaa-Pro aminopeptidase-1, Xaa-Pro aminopeptidase-2, Xaa-Pro dipeptidase, XPD, XpmA, XPNEP2, XPNPEP-1, XPNPEP-2, XPNPEP1, XPNPEP2, XPNPEP3, YpdF

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.11 Aminopeptidases

3.4.11.9 Xaa-Pro aminopeptidase

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Results	in table
12	Activating Compound
7729	AA Sequence
5	Application
1	CAS Registry Number
34	Cloned(Commentary)
14	Crystallization (Commentary)
96	Disease/ Diagnostics
44	General Information
3	General Stability
1	IC50 Value
256	Inhibitors
25	kcat/KM [mM/s]
25	Ki Value [mM]
118	KM Value [mM]
33	Localization
96	Metals/Ions
45	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
467	Organism
51	PDB ID
38	pH Optimum
7	pH Range
13	pH Stability
9	Posttranslational Modification
104	Protein Variants
37	Purification (Commentary)
7	Reaction
1	Reaction Type
108	Reference
63	Source Tissue
19	Specific Activity [micromol/min/mg]
3	Storage Stability
326	Substrates and Products (Substrate)
56	Subunits
181	Synonyms
22	Temperature Optimum [°C]
5	Temperature Range [°C]
18	Temperature Stability [°C]
92	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 3.4.11.9 - Xaa-Pro aminopeptidase

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0.016

Homo sapiens

humans with previous angiotensin-converting enzyme-inhibitor treatment-associated angio-oedema

653085

0.022 - 0.023

Homo sapiens

humans without angiotensin-converting enzyme-inhibitor treatment-associated angio-oedema

653085

0.0375

Sus scrofa

recombinant wild-type enzyme, substrate bradykinin

649942

0.17

Escherichia coli

mutant R404A, pH 7.5, 37°C

0.21

0.95

mutant R404A, presence of guanidine, pH 7.5, 37°C

667712

1.343

Lactococcus lactis

36047

1480

Plasmodium falciparum

purified recombinant enzyme, pH 8.0, 37°C

752716

177.69

Aspergillus oryzae

Q2U7S5

pH 8.5, 50°C, purified recombinant enzyme

3.45

31.7

3534

additional information

9 entries