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Literature summary for 3.4.11.9 extracted from

  • Adam, A.; Cugno, M.; Molinaro, G.; Perez, M.; Lepage, Y.; Agostoni, A.
    Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors (2002), Lancet, 359, 2088-2089.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular plasma Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bradykinin + H2O Homo sapiens enzyme activity in plasma of humans with previous angio-oedema, a rare but potentially life-threatening side-effect of angiotensin-converting enzyme inhibitor treatment, is low compared to humans without this sensitivity and might be a predisposing factor for development of angio-oedema Arg + des-Arg-bradykinin
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma low activity in patients with angio-oedema Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.016
-
humans with previous angiotensin-converting enzyme-inhibitor treatment-associated angio-oedema Homo sapiens
0.022 0.023 humans without angiotensin-converting enzyme-inhibitor treatment-associated angio-oedema Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bradykinin + H2O hydrolysis of the N-terminal Arg1-Pro2 bond Homo sapiens Arg + des-Arg-bradykinin
-
?
bradykinin + H2O enzyme activity in plasma of humans with previous angio-oedema, a rare but potentially life-threatening side-effect of angiotensin-converting enzyme inhibitor treatment, is low compared to humans without this sensitivity and might be a predisposing factor for development of angio-oedema Homo sapiens Arg + des-Arg-bradykinin
-
?

Synonyms

Synonyms Comment Organism
aminopeptidase P
-
Homo sapiens
More the enzyme belongs to the peptidase family M24 Homo sapiens