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3.4.11.9: Xaa-Pro aminopeptidase

This is an abbreviated version!
For detailed information about Xaa-Pro aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.9

Reaction

release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide =

Synonyms

aminoacylproline aminopeptidase, aminopeptidase P, aminopeptidase P-like enzyme, aminopeptidase P1, aminopeptidase, aminoacylproline, AMPP, AP-P, APaseP, APP, APP1, APPro, DAP-P, dapUm, Dr-smAPP, Ec-smAPP, ecAPP, hAPP1, hcAMPP, Icp55, LeAPP1, LeAPP2, M24B peptidase, mAmP, Membrane-bound AmP, Membrane-bound APP, membrane-bound proline-specific APaseP, More, Mt-smAPP, Pa-PepP, PEPP, PepQ, peptidase PepQ, PepX aminopeptidase, PfAPP, proline aminopeptidase, sll0136, small aminopeptidase-P, TgAPP, TvMP50, X-Pro aminopeptidase, X-prolyl aminopeptidase, X-prolyl aminopeptidase 2, X-prolyl aminopeptidase 3, X-prolyl peptidase, X-prolyl-dipeptidyl aminopeptidase, Xaa-Pro aminopeptidase, Xaa-Pro aminopeptidase-1, Xaa-Pro aminopeptidase-2, Xaa-Pro dipeptidase, XPD, XpmA, XPNEP2, XPNPEP-1, XPNPEP-2, XPNPEP1, XPNPEP2, XPNPEP3, YpdF

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.9 Xaa-Pro aminopeptidase

Disease

topprint

Disease on EC 3.4.11.9 - Xaa-Pro aminopeptidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alzheimer Disease
Generation of Alzheimer disease-associated amyloid ?42/43 peptide by ?-secretase can be inhibited directly by modulation of membrane thickness.
Targeting Cannabinoid Receptor Activation and BACE-1 Activity Counteracts TgAPP Mice Memory Impairment and Alzheimer's Disease Lymphoblast Alterations.
Angioedema
A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema.
A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors.
Diagnosis and treatment of bradykinin-mediated angioedema: outcomes from an angioedema expert consensus meeting.
Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema.
Asthma
Eastern Carolina Asthma Prevention Program (ECAPP): An Environmental Intervention Study Among Rural and Underserved Children with Asthma in Eastern North Carolina.
Biliary Atresia
Association of X-prolyl aminopeptidase 1 rs17095355 polymorphism with biliary atresia in Thai children.
Carcinoma
Proteome profiling of clear cell renal cell carcinoma in von Hippel-Lindau patients highlights upregulation of Xaa-Pro aminopeptidase-1, an anti-proliferative and anti-migratory exoprotease.
Carcinoma, Renal Cell
Proteome profiling of clear cell renal cell carcinoma in von Hippel-Lindau patients highlights upregulation of Xaa-Pro aminopeptidase-1, an anti-proliferative and anti-migratory exoprotease.
Cervical Intraepithelial Neoplasia
XPNPEP2 is overexpressed in cervical cancer and promotes cervical cancer metastasis.
Ciliopathies
Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy.
Lights on for aminopeptidases in cystic kidney disease.
Cough
PNPT1 and PCGF3 variants associated with angiotensin-converting enzyme inhibitor-induced cough: a nested case-control genome-wide study.
Kidney Diseases
Mitochondrial aminopeptidase deletion increases chronological lifespan and oxidative stress resistance while decreasing respiratory metabolism in S. cerevisiae.
Kidney Diseases, Cystic
Structure of the human aminopeptidase XPNPEP3 and comparison of its in vitro activity with Icp55 orthologs: Insights into diverse cellular processes.
Lymphatic Metastasis
XPNPEP2 is associated with lymph node metastasis in prostate cancer patients.
XPNPEP2 is overexpressed in cervical cancer and promotes cervical cancer metastasis.
Lymphoma
ECAPP chemotherapy for lymphoma.
Microcephaly
Developmental retardation, microcephaly, and peptiduria in mice without aminopeptidase P1.
Neoplasm Metastasis
XPNPEP2 is associated with lymph node metastasis in prostate cancer patients.
XPNPEP2 is overexpressed in cervical cancer and promotes cervical cancer metastasis.
Neoplasms
Identification of DEGs and transcription factors involved in H. pylori-associated inflammation and their relevance with gastric cancer.
XPNPEP2 is associated with lymph node metastasis in prostate cancer patients.
XPNPEP2 is overexpressed in cervical cancer and promotes cervical cancer metastasis.
XPNPEP3 is a novel transcriptional target of canonical Wnt/?-catenin signaling.
Primary Ovarian Insufficiency
Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene.
Prostatic Neoplasms
XPNPEP2 is associated with lymph node metastasis in prostate cancer patients.
Stroke
Recurrent ischemic stroke in patients with atrial fibrillation ablation and prior stroke: A study based on etiological classification.
Trichomonas Infections
The 50kDa metalloproteinase TvMP50 is a zinc-mediated Trichomonas vaginalis virulence factor.
TvMP50 is an immunogenic metalloproteinase during male trichomoniasis.
Uterine Cervical Neoplasms
XPNPEP2 is overexpressed in cervical cancer and promotes cervical cancer metastasis.
xaa-pro aminopeptidase deficiency
Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency.
Deficiency of aminopeptidase P1 causes behavioral hyperactivity, cognitive deficits, and hippocampal neurodegeneration.