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3.4.11.9: Xaa-Pro aminopeptidase

This is an abbreviated version!
For detailed information about Xaa-Pro aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.9

Reaction

release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide =

Synonyms

aminoacylproline aminopeptidase, aminopeptidase P, aminopeptidase P-like enzyme, aminopeptidase P1, aminopeptidase, aminoacylproline, AMPP, AP-P, APaseP, APP, APP1, APPro, DAP-P, dapUm, Dr-smAPP, Ec-smAPP, ecAPP, hAPP1, hcAMPP, Icp55, LeAPP1, LeAPP2, M24B peptidase, mAmP, Membrane-bound AmP, Membrane-bound APP, membrane-bound proline-specific APaseP, More, Mt-smAPP, Pa-PepP, PEPP, PepQ, peptidase PepQ, PepX aminopeptidase, PfAPP, proline aminopeptidase, sll0136, small aminopeptidase-P, TgAPP, TvMP50, X-Pro aminopeptidase, X-prolyl aminopeptidase, X-prolyl aminopeptidase 2, X-prolyl aminopeptidase 3, X-prolyl peptidase, X-prolyl-dipeptidyl aminopeptidase, Xaa-Pro aminopeptidase, Xaa-Pro aminopeptidase-1, Xaa-Pro aminopeptidase-2, Xaa-Pro dipeptidase, XPD, XpmA, XPNEP2, XPNPEP-1, XPNPEP-2, XPNPEP1, XPNPEP2, XPNPEP3, YpdF

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.9 Xaa-Pro aminopeptidase

Inhibitors

Inhibitors on EC 3.4.11.9 - Xaa-Pro aminopeptidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R,3R)-(2-hydroxy-3-amino-4-phenyl-butanoic acid)-thiazolidide
(2R,3R)-3-amino-1-oxo-4-phenyl-1-(1,3-thiazolidin-3-yl)butan-2-ol
(2R,3R)-3-amino-2-hydroxy-4-phenylbutanoyl-L-Pro
(2R,3S)-(2-hydroxy-3-amino-4-phenyl-butanoic acid)-thiazolidide
(2R,3S)-3-amino-1-oxo-4-phenyl-1-(1,3-thiazolidin-3-yl)butan-2-ol
(2R,3S)-3-amino-2-hydroxy-4-phenylbutanoyl-L-Pro
(2S,3R)-(2-hydroxy-3-amino-4-phenyl-butanoic acid)-Pro-methyl ester
(2S,3R)-(2-hydroxy-3-amino-4-phenyl-butanoic acid)-Pro-Phe-methyl ester
(2S,3R)-(2-hydroxy-3-amino-4-phenyl-butanoic acid)-thiazolidide
(2S,3R)-(2-hydroxy-3-amino-5-methylhexanoic acid)-thiazolidide
(2S,3R)-2-hydroxy-3-amino-4-phenyl-butanoic acid pyrrolidide
(2S,3R)-3-amino-1-oxo-4-phenyl-1-(1,3-thiazolidin-3-yl)butan-2-ol
(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl pyrrolidide
(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl-L-Pro
(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl-L-Pro-L-Phe-OMe
(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl-L-Pro-OMe
(2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl-thiazolidide
(2S,3R)-3-amino-5-methyl-1-oxo-1-(1,3-thiazolidin-3-yl)hexan-2-ol
(2S,3S)-(2-hydroxy-3-amino-4-phenyl-butanoic acid)-Pro-methyl ester
(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl-L-Pro-OMe
1,10-phenanthroline
2-hydroxy-3-aminoacyl-Pro-OH dipeptides
-
2-mercaptoethanol
2-mercaptomethyl-3-guanidinoethylthiopropanoic acid
4-chloromercuriphenyl sulfonic acid
4-hydroxymercuribenzenesulfonate
-
-
4-hydroxymercuribenzoate
8-hydroxyquinoline
-
-
acetyl-Phe(NO2)-Pro-Pro-HN-CH2-CH2-NH-2-aminobenzoyl
-
0.5 mM, 30% inhibition of hydrolysis of (4-nitr)Phe-Pro-Pro-HN-CH2-CH2-NH-o-aminobenzoyl
amastatin
antipain
-
-
Aprotinin
apstatin
Arg-Pro
substrate inhibition at concentrations above 3 mM
bestatin
bradykinin
captopril
CH3HgCl
-
-
cilazaprilat
-
inhibits hydrolysis of Gly-Pro-Hyp, Gly-Pro-4-methyl-7-coumarylamide, substance P, and beta-casomorphin. Weak inhibition of hydrolysis of Arg-Pro-Pro. No effect on hydrolysis of bradykinin
Cr6+
CrVI, a heavy metal endocrine-disrupting chemical industrially widely used, gestational exposure to CrVI increases germ cell/oocyte apoptosis and advance germ cell nest (GCN) breakdown. CrVI increases X-prolyl aminopeptidase (Xpnpep) 2 (a marker for premature ovarian failure in humans) during germ cell nest (GCN) breakdown, it decreases Xpnpep2 during postnatal follicle development, and increases colocalization of Xpnpep2 with collagens Col3 and Col4. Phenotype, overview
diethyldicarbonate
50% inhibition at 0.011 mM
diisopropylphosphofluoridate
-
-
dithioerythritol
-
-
dithiothreitol
enalapril
-
significant inhibition after repeated oral dosage
enalaprilat
-
inhibition only in presence of Mn2+
enaprilat
-
inhibits hydrolysis of Gly-Pro-Hyp, Gly-Pro-4-methylcoumarin 7-amide, substance P, and beta-casomorphin. Weak inhibition of hydrolysis of Arg-Pro-Pro. No effect on hydrolysis of bradykinin
Fe2+
slight activation at 0.05 mM, complete inhibition at 1 mM
glutathione
10% inhibition at 1 mM in absence of cations
hydrazine
inactivates wild-type hcAMPP and R535A mutant enzymes
iodoacetate
-
-
L-Ala-(N-methyl)L-Ala-L-Ala
competitive
L-Ala-L-Ala-L-Ala
competitive
L-Ala-L-Pro-L-Ala
competitive; competitive, 50% inhibition at 0.22 mM
L-Pro-L-Leu
product inhibition, a third metal binding site is formed by two conserved His-residues and L-Pro-L-Leu
Leu-Pro
substrate inhibition at concentrations above 4 mM
N-benzyloxycarbonyl-Pro-prolinal
-
-
N-[1-(R,S)-carboxy-(2-phenylethyl)]-thiopropanoic acid
-
-
nitrilotriacetic acid
-
-
pefabloc
-
-
pepstatin A
complete inhibition at 0.1-5.0 mM
Peptides with N-terminal Pro
-
product inhibition
phenylmethylsulfonyl fluoride
phosphoramidon
-
-
Pro-Gly-Pro
-
-
Pro-HN-CH2-CH2-NH-2-aminobenzoyl
Pro-Pro-Ala
-
-
puromycin
-
-
ramiprilat
Ser-Pro
substrate inhibition at concentrations above 10 mM
additional information
-