2.1.1.6: catechol O-methyltransferase
This is an abbreviated version!
For detailed information about catechol O-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.6
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2.1.1.6
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dopamine
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val158met
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catechols
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parkinson
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monoamine
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dopaminergic
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schizophrenia
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prefrontal
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levodopa
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estrogen
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val
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o-methylation
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psychiatric
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norepinephrine
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entacapone
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l-dopa
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tolcapone
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serotonin
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noradrenaline
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dyskinesia
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neurotransmitter
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striatal
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psycho
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dopac
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carbidopa
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verbal
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3,4-dihydroxyphenylacetic
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extraneuronal
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5-httlpr
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low-activity
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parkinsonian
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homovanillic
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normetanephrine
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benserazide
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antiparkinsonian
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synthesis
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endophenotype
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dsm-iv
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3h-noradrenaline
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2-methoxyestradiol
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analysis
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tropolone
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updrs
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slc6a4
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dihydroxyphenylacetic
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amantadine
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pargyline
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oxidase-b
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phenylethanolamine-n-methyltransferase
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metanephrine
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selegiline
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medicine
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antisocial
- 2.1.1.6
- dopamine
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val158met
- catechols
- parkinson
-
monoamine
-
dopaminergic
-
schizophrenia
-
prefrontal
- levodopa
- estrogen
- val
-
o-methylation
-
psychiatric
- norepinephrine
- entacapone
- l-dopa
- tolcapone
- serotonin
- noradrenaline
- dyskinesia
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neurotransmitter
- striatal
-
psycho
-
dopac
- carbidopa
-
verbal
-
3,4-dihydroxyphenylacetic
-
extraneuronal
-
5-httlpr
-
low-activity
-
parkinsonian
-
homovanillic
- normetanephrine
- benserazide
-
antiparkinsonian
- synthesis
-
endophenotype
-
dsm-iv
-
3h-noradrenaline
- 2-methoxyestradiol
- analysis
- tropolone
-
updrs
-
slc6a4
-
dihydroxyphenylacetic
- amantadine
- pargyline
-
oxidase-b
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phenylethanolamine-n-methyltransferase
- metanephrine
- selegiline
- medicine
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antisocial
Reaction
Synonyms
catechol methyltransferase, catechol-O-methyl transferase, catechol-O-methyl transferase, membrane bound, catechol-O-methyl transferase, soluble, catechol-O-methyltransferase, catechol-O-transferase, catecholamine O-methyltransferase, COMT, COMT I, COMT II, COMT-mb, COMT-s, COMT1, COMT2, CTOMT1, L-COMT, MB-COMT, methyltransferase, catechol, S-COMT, SCOMT
ECTree
2.1.1.6 catechol O-methyltransferaseAdvanced search results
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Application on EC 2.1.1.6 - catechol O-methyltransferase
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
analysis
medicine
synthesis
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predictive artificial neural network models of the soluble COMT activity for production in a batch Escherichia coli culture process. Models predict a maximum COMT activity of 183.73 nmol/h, at 40°C, pH 6.5 and stirring rate of 351 rpm, and 132.90 nmol/h, at 35°C, pH 6.2 and stirring rate of 351 rpm, for semi-defined and complex medium, respectively. These results represent a 4fold increase in total activity by comparison to the standard operational conditions
analysis
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high-performance liquid chromatography determination of methionine adenosyltransferase activity using catechol-O-methyltransferase-coupled fluorometric detection, a nonradioactive, sensitive, rapid, and specific method for the determination of methionine adenosyltransferase activity
analysis
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design of electrochemical biosensor systems for the detection of specific DNA sequences in PCR-amplified nucleic acids related to the catechol-O-methyltransferase Val108/158Met polymorphism based on intrinsic guanine signal
medicine
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genetic variation in COMT gene (MIM 116790) is associated with altered prefrontal cortex function and higher risk for schizophrenia. A common single-nucleotide polymorphism within COMT, Val158Met, significantly affects protein abundance and enzyme activity but not mRNA expression levels. Val is a predominant factor that determines higher COMT activity in the prefrontal cortex, which presumably leads to lower synaptic dopamine levels and relatively deleterious prefrontal function
medicine
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inhibition of catechol-O-methyltransferase is an important approach in the treatment of Parkinson's disease
medicine
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a functional COMT polymorphism (Val158Met) predicts performance in tasks of prefrontal executive function and the neurophysiological response measured with electroencephalography and functional magnetic resonance imaging in tasks assessing working memory. In fact, individuals with the Val/Val genotype, which encodes for the high-activity enzyme resulting in lower dopamine concentrations in the prefrontal cortex, perform less well and are less efficient physiologically than Met/Met individuals
medicine
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association between the COMT Val158Met polymorphism and anger-related personality traits in suicide attempters. COMT Val158Met shows a strong effect on Trait Anger and Anger Control scores in female suicide attempters and a weaker effect on the Trait Anger score in violent suicide attempters of both genders
medicine
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association of the catechol-O-methyltransferase polymorphism with methylphenidate response in a classroom setting in children with attention-deficit hyperactivity disorder. 62.5% of the patients showing a good response to methylphenidate treatment have the Val/Val genotype, 41.7% and 11.7% of the patients showing a poor response to methylphenidate treatment as assessed by their teachers have the Val/Met and Met/Met genotypes
medicine
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catechol-O-methyltransferase activity and protein expression are increased in the substantia nigra after inflammation induced by lipopolysaccharides. These changes in glial and perivascular catechol-O-methyltransferase activity may have clinical relevance for Parkinsons disease drug treatment due to increased metabolism of levodopa in the brain
medicine
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COMT activity and increased formation of depurinating adducts can be critical factors leading to initiation of breast cancer
medicine
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COMT activity has an influence on cell transforming activity and its related genetic effects of catechol estrogens imply that an individual activity of COMT may be one of the etiological factors in endogenous estrogen-induced carcinogenesis
medicine
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COMT genotype directly influences cognitive phenotype in Parkinsons disease through altering activation in a frontoparietal executive neural network. COMT genotype has differing effects on prefrontal function according to underlying dopaminergic state
medicine
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COMT Val158Met polymorphism modulates the association between physical activity, areal bone mineral density, and trabecular volumetric bone mineral density, suggesting that this polymorphism is of importance for bone mineral density in subjects with a low level of physical activity
medicine
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in boys there appeared to be a population shift toward higher verbal IQ with increasing Met allele dose (Val108/158Met polymorphism). The effects on IQ are significantly greater in pubertal than in prepubertal boys. In girls, there are no significant effects of genotype on cognition
medicine
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L-dopa treatment is an acquired cause of hyperhomocysteinemia. The mechanism underlying L-dopa-related hyperhomocysteinemia is the O-methylation of the drug catalyzed by the enzyme catechol-O-methyltransferase. L-Dopa is the gold standard in the symptomatic management of Parkinsons disease, but its long-term treatment is complicated by the elevation in plasma homocysteine concentrations, due to the O-methylation by COMT
medicine
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low COMT activity leads to increased pain sensitivity via a beta2/3-adrenergic mechanism. These findings are of considerable clinical importance, suggesting that pain conditions resulting from low COMT activity and/or elevated catecholamine levels can be treated with pharmacological agents that block both beta2- and beta3-adrenergic receptors
medicine
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significant association between the COMT Val158Met polymorphism and specific clinical features related to the onset of psychosis in a large and representative sample of first episode patients. These results suggest that COMT genotype may have a role in the pathogenesis of psychotic disorders and therefore takes part in the etiological model for schizophrenia and other psychoses
medicine
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single nucleotide polymorphisms rs6269, rs4633, rs4818, and rs4680, tagging the common putative functional COMT haplotypes, are genotyped in 435 adult subjects with a clinical diagnosis of ADHD and 383 controls and analyzed for association with attention-deficit/hyperactivity disorder and the hyperactivity/impulsivity and in attention dimensions from the Adult ADHD Self-Report Scale. Haplotype analysis reveales that the rs6269 risk allele tags the suggested high COMT-activity haplotype, which is associated with the highest hyperactivity/impulsivity score
medicine
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the COMT Val158Met polymorphism is associated with fracture risk in elderly men, through a mechanism independent of bone mineral density
medicine
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the functional catechol-O-methyltransferase (COMT) Val158Met polymorphism interacts significantly with total Childhood Trauma Questionnaire abuse scores to impact perceived dissociation. The Val/Val genotype is associated with increasing levels of dissociation in participants exposed to higher levels of childhood trauma. The opposite is observed in people with Met/Met genotypes who display decreased dissociation with increasing self-reported childhood trauma. COMT Val158Met polymorphism is involved in mediating the relationship between trauma and psychopathology
medicine
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the present meta-analysis provides tentative support for the COMT Val158met polymorphism as a possible risk factor for panic disorder, with differential effects in Caucasian and Asian populations, and suggests a female-specific effect
medicine
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therapeutic potential of manipulating COMT activity to alter dopaminergic neurotransmission in the prefrontal cortex
medicine
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best-characterized single nucleotide polymorphism of the COMT gene consists of a valine-to-methionine substitution at codon 108/158. In homozygous carriers of Met, but not Val alleles, the activity of COMT and methionine sulfoxide reductase are significantly correlated throughout all tested brain regions
medicine
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both melanotic melanoma SK-mel-1 and Ha-Cat cells express COMT activity. In SK-mel-1, COMT activity is reduced nearly 50% both 24 h and 48 h after a high dose UVB. In Ha-Cat cells, COMT activity increases 24 h after a high dose UVB but decreases at 48 h. Tolcapone increases significantly the cytotoxic effect of high dose UVB irradiation only in HaCat. High concentrations of tolcapone reduce melanin levels in melanoma cells parallel to reduced cell numbers
medicine
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despite successful lesioning of dopaminergic and noradrenergic neurons, no changes in COMT protein expression or activity are observed
medicine
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enzymatic activities of functional COMT single-nucleotide polymorphisms in red blood cells in 24 healthy human volunteers, supplemented with750 mg of epigallocatechin-3-gallate.The homozygousVal-Met substitution in the SNPrs 4680 results in significantly decreased COMT activity. Enzymatic COMT activities are also affected by the other COMT polymorphisms. Epigallocatechin-3-gallate plasma levels significantly increase after intervention.They are not influenced by any of the COMT SNPs and different enzyme activities. Ingestion of 750 mg epigallocatechin-3-gallate does not result in impairment of COMT activity. However, COMT activity is significantly increased by 24% after epigallocatechin-3-gallate consumption
medicine
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subjects carrying the Val/Val genotype of the Val108/158Met polymorphism show increased energy expenditure and fat-oxidation upon ingestion of green tea catechins vs placebo, whereas subjects carrying the Met/Met genotype react similarly to green tea and placebo ingestion. The differences in responses are due to the different responses on PL ingestion, but similar responses to green tea ingestion. The different alleles of the functional COMT Val108/158Met polymorphism appear to play a role in the inter-individual variability for energy expenditure and fat oxidation after green tea treatment
medicine
inhibition of catechol-O-methyltransferase enzyme by entacapone decreases the antiproliferative effects of fisetin and quercetin on Hep-G2 cells
