Information on EC 2.1.1.6 - catechol O-methyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
2.1.1.6
-
RECOMMENDED NAME
GeneOntology No.
catechol O-methyltransferase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
methyl group transfer
-
-
-
-
O-methylation
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
3,5-dimethoxytoluene biosynthesis
-
Betalain biosynthesis
-
betaxanthin biosynthesis
-
dopamine degradation
-
L-dopa degradation
-
Metabolic pathways
-
noradrenaline and adrenaline degradation
-
Steroid hormone biosynthesis
-
Tyrosine metabolism
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:catechol O-methyltransferase
The mammalian enzyme acts more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
catechol methyltransferase
-
-
-
-
catechol-O-methyl transferase
-
-
catechol-O-methyl transferase
-
-
catechol-O-methyl transferase, membrane bound
-
-
catechol-O-methyl transferase, soluble
-
-
catechol-O-methyltransferase
-
-
catechol-O-methyltransferase
-
-
catechol-O-methyltransferase
-
soluble and membrane-bound isoforms encoded by a single gene
catechol-O-methyltransferase
-
-
catechol-O-methyltransferase
-
-
catechol-O-methyltransferase
-
-
catechol-O-transferase
-
-
catecholamine O-methyltransferase
-
-
-
-
COMT
A3F6Y9
-
COMT
P21964
-
COMT
P22734
-
COMT
-
-
COMT I
-
-
-
-
COMT II
-
-
-
-
COMT-mb
-
catechol-O-methyltransferase, membrane-bound isoform
COMT-s
-
catechol-O-methyltransferase, soluble isoform
COMT1
-
isoform
COMT2
-
isoform
L-COMT
-
large variant of catechol O-methyltransferase
MB-COMT
-
membrane-bound COMT
MB-COMT
-
-
MB-COMT
-
membrane-bound enzyme form
MB-COMT
-
membrane-bound form of catechol-O-methyltransferase
MB-COMT
-
membrane-bound isoform
MB-COMT
-
two molecular forms: a soluble form (S-COMT) and in another form associated with membranes (MB-COMT)
MB-COMT
-
membrane-bound catechol-O-methyltransferase
MB-COMT
-
two molecular forms: a soluble form (S-COMT) and in another form associated with membranes (MB-COMT)
MB-COMT
-
two molecular forms: a soluble form (S-COMT) and in another form associated with membranes (MB-COMT)
MB-COMT
-
membrane-bound form of catechol-O-methyltransferase
MB-COMT
-
two molecular forms: a soluble form (S-COMT) and in another form associated with membranes (MB-COMT)
methyltransferase, catechol
-
-
-
-
S-COMT
-
soluble COMT
S-COMT
-
-
S-COMT
-
soluble enzyme form
S-COMT
-
soluble form of catechol-O-methyltransferase
S-COMT
-
soluble isoform
S-COMT
-
two molecular forms: a soluble form (S-COMT) and in another form associated with membranes (MB-COMT)
S-COMT
P21964
-
S-COMT
-
soluble catechol-O-methyltransferase
S-COMT
-
two molecular forms: a soluble form (S-COMT) and in another form associated with membranes (MB-COMT)
S-COMT
-
small variant of catechol O-methyltransferase
S-COMT
-
two molecular forms: a soluble form (S-COMT) and in another form associated with membranes (MB-COMT)
S-COMT
P22734
-
S-COMT
P22734
soluble COMT
S-COMT
-
soluble form of catechol-O-methyltransferase
S-COMT
-
two molecular forms: a soluble form (S-COMT) and in another form associated with membranes (MB-COMT)
SCOMT
-
-
SCOMT
-
soluble isoform
CAS REGISTRY NUMBER
COMMENTARY
9012-25-3
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
common marmoset
-
-
Manually annotated by BRENDA team
African catfish
-
-
Manually annotated by BRENDA team
CHO cell line
-
-
Manually annotated by BRENDA team
2 forms
-
-
Manually annotated by BRENDA team
2 forms which differ in nature of intramolecular disulfide bonds
-
-
Manually annotated by BRENDA team
a common single-nucleotide polymorphism within COMT, Val158Met, significantly affects protein abundance and enzyme activity but not mRNA expression levels. Val is a predominant factor that determines higher COMT activity in the prefrontal cortex, which presumably leads to lower synaptic dopamine levels and relatively deleterious prefrontal function
-
-
Manually annotated by BRENDA team
both S-COMT and MB-COMT
-
-
Manually annotated by BRENDA team
hepatoma cell line G2
-
-
Manually annotated by BRENDA team
recombinant
-
-
Manually annotated by BRENDA team
thalamus COMT isoform
UniProt
Manually annotated by BRENDA team
variants 108M and 108V
-
-
Manually annotated by BRENDA team
wild type and variant isoform
-
-
Manually annotated by BRENDA team
-
P22734-2
UniProt
Manually annotated by BRENDA team
; Sprague-Dawley rats
-
-
Manually annotated by BRENDA team
both S-COMT and MB-COMT
-
-
Manually annotated by BRENDA team
Dahl salt-sensitive rats
-
-
Manually annotated by BRENDA team
gene expression in Escherichia coli
-
-
Manually annotated by BRENDA team
male sprague-dawley rats
-
-
Manually annotated by BRENDA team
male Wistar rats
-
-
Manually annotated by BRENDA team
particulate enzyme
-
-
Manually annotated by BRENDA team
Rattus norvegicus S-COMT
S-COMT
-
-
Manually annotated by BRENDA team
Streptomyces griseus S-COMT
S-COMT
-
-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM