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2.1.1.6: catechol O-methyltransferase

This is an abbreviated version!
For detailed information about catechol O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.6

Reaction

S-adenosyl-L-methionine
+
a catechol
=
S-adenosyl-L-homocysteine
 +
a guaiacol

Synonyms

catechol methyltransferase, catechol-O-methyl transferase, catechol-O-methyl transferase, membrane bound, catechol-O-methyl transferase, soluble, catechol-O-methyltransferase, catechol-O-transferase, catecholamine O-methyltransferase, COMT, COMT I, COMT II, COMT-mb, COMT-s, COMT1, COMT2, CTOMT1, L-COMT, MB-COMT, methyltransferase, catechol, S-COMT, SCOMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.6 catechol O-methyltransferase

KM Value

KM Value on EC 2.1.1.6 - catechol O-methyltransferase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0022 - 0.0082
(-)-epicatechin
-
-
0.0039 - 0.0067
(-)-epigallocatechin
-
-
0.02
(R)-1,2-dihydroxy-4-[2-(methylamino)butyl]benzene
-
isoform sCOMT, in phosphate buffer (pH 7.4)
0.03
(R)-3,4-dihydroxymethamphetamine
-
isoform sCOMT, in phosphate buffer (pH 7.4)
0.09
(R)-N-ethyl-3,4-dihydroxyamphetamine
-
isoform sCOMT, in phosphate buffer (pH 7.4)
0.02
(S)-1,2-dihydroxy-4-[2-(methylamino)butyl]benzene
-
isoform sCOMT, in phosphate buffer (pH 7.4)
0.03
(S)-3,4-dihydroxymethamphetamine
-
isoform sCOMT, in phosphate buffer (pH 7.4)
0.07
(S)-N-ethyl-3,4-dihydroxyamphetamine
-
isoform sCOMT, in phosphate buffer (pH 7.4)
0.000148 - 0.0175
2-hydroxyestradiol
0.014
2-hydroxyestradiol-17beta
-
-
0.64
3,4-dihydroxyphenylacetic acid
-
-
0.0024
4-hydroxyequilenin
-
pH 7.8
0.00037 - 0.0161
4-hydroxyestradiol
0.5
6,7-dihydroxycoumarin
-
-
0.0014 - 0.48
adrenaline
0.0064
aesculetin
-
pH 7.4, 37°C
0.0022 - 0.0089
catechin
0.00836 - 0.833
catechol
0.0006
Catecholestradiol
-
-
0.0012
Catecholestrone
-
-
0.05
dobutamine
-
-
0.0005 - 0.44
dopamine
0.0043 - 0.0257
epicatechin
0.0081 - 0.0117
epigallocatechin
0.00017 - 0.0048
epigallocatechin gallate
0.0009 - 1
epinephrine
0.0062 - 0.015
esculetin
0.0015
fisetin
-
S-COMT, 0.25 mM S-adenosyl-L-methionine
0.00091 - 0.121
isoproterenol
0.266 - 0.613
levodopa
0.0055 - 1.856
norepinephrine
0.0038
p-nitrocatechol
-
-
0.0015 - 0.0069
quercetin
0.043 - 0.156
R-salsolinol
0.0031 - 0.6
S-adenosyl-L-methionine
0.0113 - 0.0797
salvianolic acid B
additional information
additional information
-