Literature summary for 2.1.1.6 extracted from

Yavich, L.; Forsberg, M.M.; Karayiorgou, M.; Gogos, J.A.; Maennistoe, P.T.
Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum (2007), J. Neurosci., 27, 10196-10209.

Search for more literature for 2.1.1.6

Application

Application	Comment	Organism
medicine	therapeutic potential of manipulating COMT activity to alter dopaminergic neurotransmission in the prefrontal cortex	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	significant contribution of COMT in modulating the dynamics of dopamine overflow in the prefrontal cortex. Evoked dopamine overflow shows that removal of dopamine is twofold slower in the prefrontal cortex of mice lacking COMT than in wild-type mice, indicating that half of the dopamine decline in this brain region results from COMT-mediated enzymatic degradation. Lack of COMT does not influence dopamine overflow/decline in the dorsal striatum	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
COMT	-	Mus musculus

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Release 2023.1 (January 2023)